How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: IL18

    Description: interleukin 18 (interferon-gamma-inducing factor)

    Entrez Gene ID: 3606

    SwissProt Acc Number: Q14116

    RefSeq: NM_001562

    It was suspected to be CHD related:

    ..A single intravenous dose of IL18BP decreased neointimal hyperplasia and improved arterial L/A ratios in an atherosclerotic balloon-injury animal model...

    From PMID: 18455646, in Journal J Vasc Surg , 2008


    References

    There were 5 potential papers with IL18 and CHD.

    PMIDTitleJournalsDetails
    18455646 Interleukin 18 binding protein (IL18-BP) inhibits neointimal hyperplasia after balloon injury in an atherosclerotic rabbit model.Journal of vascular surgeryMore Details
    17445542 A common interleukin 18 haplotype is associated with higher body mass index in subjects with diabetes and coronary heart disease.Metabolism: clinical and experimentalMore Details
    17962365 IL18 haplotypes are associated with serum IL-18 concentrations in a population-based study and a cohort of individuals with premature coronary heart disease.Clinical chemistryMore Details
    17951325 "Free Interleukin (IL)-18 levels, and the impact of IL18 and IL18BP genetic variation, in CHD patients and healthy men.""Arteriosclerosis, thrombosis, and vascular biology"More Details
    16043644 Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease.CirculationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 8 unique genes interacted with IL18. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    IL18BP Reconstituted Complex11907126 CHD related
    CASP4 Biochemical Activity12096920|15326478 No
    CASP1 Biochemical Activity12096920|9334240 CHD related
    UBC Affinity Capture-MS21139048|21906983 No
    CASP3 in vitro9334240 CHD related
    IL18R1 in vitro;in vivo9325300 CHD related
    IL18RAP in vivo9792649 CHD related
    IL1RL2 in vitro;in vivo9325300 No


    Involved FDA drugs

    There was no drug associated with IL18