How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: IL2

    Description: interleukin 2

    Entrez Gene ID: 3558

    SwissProt Acc Number: P60568

    RefSeq: NM_000586

    It was suspected to be CHD related:

    .."Data demonstrate that in the context of LPS-triggered cardiac and coronary injury, A(2A)AR activity protects myocardial viability without modifying contractile dysfunction, and selectively modulates cytokine (IL-2, IL-5) release."..

    From PMID: 22192288, in Journal Int J Cardiol. , 2011


    There were 1 potential papers with IL2 and CHD.

    24210839 "Effects of albumin and synthetic polypeptide-coated oxygenators on IL-1, IL-2, IL-6, and IL-10 in open heart surgery."Asian journal of surgery / Asian Surgical AssociationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 11 unique genes interacted with IL2. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    IL2RB in vivo11035066,8049354 No
    IFNA1 in vitro3262520 No
    IL2 in vitro12582206 CHD related
    DGKA Co-localization8626603 No
    IL21R Affinity Capture-Western11418623 No
    FOXK2 in vitro9065434 No
    IL2RA in vivo1993646 CHD related
    CD53 in vivo7963560 No
    NGFR in vitro1316918 No
    IL2RG in vivo10662798,8049354 No
    SHC1 in vitro10662798 No

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    experimentalDB02581"5-[2,3-Dichloro-4-(5-{1-[2-(2-Guanidino-4-Methyl-Pentanoylamino)-Acetyl]-Piperidin-4-Yl}-1-Methyl-1h-Pyrazol-3-Yl)-Phenoxymethyl]-Furan-2-Carboxylic Acid"
    experimentalDB03453(R)-N-[2-[1-(Aminoiminomethyl)-3-Piperidinyl]-1-Oxoethyl]-4-(Phenylethynyl)-L-Phenylalanine Methylester
    experimentalDB03455(1h-Indol-3-Yl)-(2-Mercapto-Ethoxyimino)-Acetic Acid