How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: IL6

    Description: "interleukin 6 (interferon, beta 2)"

    Entrez Gene ID: 3569

    SwissProt Acc Number: P05231

    RefSeq: NM_000600

    It was suspected to be CHD related:

    .."It can also be protective in CAD patients since the reduced adiponectin-induced IL-6 release in CAD macrophages compared to controls, could be beneficial in the development of inflammation related atherosclerosis. "..

    From PMID: 21626471, in Journal Horm Metab Res. , 2011


    There were 35 potential papers with IL6 and CHD.

    24117346 Genetic variation and gender determine bradykinin type 1 receptor responses in human tissue: implications for the ACE-inhibitor-induced effects in patients with coronary artery disease."Clinical science (London, England : 1979)"More Details
    24072607 Interleukin 6(-174G/C) Variant and its Circulating Levels in Coronary Artery Disease Patients and Their First Degree Relatives.InflammationMore Details
    23906927 Inflammation and sudden cardiac death in a community-based population of older adults: the Cardiovascular Health Study.Heart rhythm : the official journal of the Heart Rhythm SocietyMore Details
    23121518 TLR4 expression on monocyte subsets in myocardial infarction.Journal of internal medicineMore Details
    23357300 Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease (CAD) patients.CytokineMore Details
    23132698 Active acromegaly is associated with decreased hs-CRP and NT-proBNP serum levels: insights from the Belgian registry of acromegaly.European journal of endocrinology / European Federation of Endocrine SocietiesMore Details
    24134608 The effect of statin therapy withdrawal on monocyte subsets.European journal of clinical investigationMore Details
    23665315 Vasoprotective effect of vitamin E: rescue of ethanol-induced atherosclerosis and inflammatory stress in rat vascular wall.International immunopharmacologyMore Details
    23881440 Association between interleukin 6 and interleukin 16 gene polymorphisms and coronary heart disease risk in a Chinese population.The Journal of international medical researchMore Details
    23505291 Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.Circulation. Cardiovascular geneticsMore Details
    23125512 "Association of constitutional type of Ayurveda with cardiovascular risk factors, inflammatory markers and insulin resistance."Journal of Ayurveda and integrative medicineMore Details
    22780915 A novel multiplex polymerase chain reaction assay for profile analyses of gene expression in peripheral blood.BMC cardiovascular disordersMore Details
    21130994 Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction.AtherosclerosisMore Details
    21087078 Genetic and environmental influences on the plasma interleukin-6 concentration in patients with a recent myocardial infarction: a case-control study.Journal of interferon & cytokine research : the official journal of theMore Details
    20112301 Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats.Molecular nutrition & food researchMore Details
    20206549 Interleukin-1 beta and interleukin-6 gene polymorphism associations with angiographically assessed coronary artery disease in Brazilians.CytokineMore Details
    20606121 Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study.CirculationMore Details
    20484148 Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in macrophages from older men and postmenopausal women.The Journal of endocrinologyMore Details
    21152190 Usefulness of C-reactive protein as a marker for prediction of future coronary events in the asian Indian population: Indian atherosclerosis research study.International journal of vascular medicineMore Details
    18922529 Higher IL-6 levels but not IL6 -174G>C or -572G>C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery.AtherosclerosisMore Details
    19084425 Association of IL6 and IL10 with renal dysfunction and the use of haemofiltration during cardiopulmonary bypass.European journal of cardio-thoracic surgery : official journal of the EuropeanMore Details
    19008156 Inflammatory response of coronary artery disease postmenopausal women is associated with the IVS1-397T > C estrogen receptor alpha polymorphism."Clinical immunology (Orlando, Fla.)"More Details
    19140875 The additive contribution from inflammatory genetic markers on the severity of cardiovascular disease.Scandinavian journal of immunologyMore Details
    18774574 Polymorphism in the IL6 promoter region is associated with the risk factors and markers of subclinical atherosclerosis in men: The Cardiovascular Risk in Young Finns Study.AtherosclerosisMore Details
    18356242 Association of serum interleukin-6 concentration with a functional IL6 -6331T>C polymorphism.Clinical chemistryMore Details
    18449426 Polymorphisms in the IL6 gene in Asian Indian families with premature coronary artery disease--the Indian Atherosclerosis Research Study.Thrombosis and haemostasisMore Details
    18573392 High-dose insulin therapy attenuates systemic inflammatory response in coronary artery bypass grafting patients.The Annals of thoracic surgeryMore Details
    17023074 Long-term prognosis after coronary bypass surgery depends on interleukin 6 polymorphism and past acute infections.International journal of cardiologyMore Details
    17661772 Does the type of surgery effect systemic response following cardiopulmonary bypass?Journal of cardiac surgeryMore Details
    17130180 "Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men."Clinical chemistryMore Details
    17950688 [Relationship between coronary artery disease and periodontal disease. What the cardiologist must know].Annales de cardiologie et d'angeiologieMore Details
    17123852 "Association between plasma IL-6, the IL6 -174G>C gene variant and the metabolic syndrome in type 2 diabetes mellitus."Molecular genetics and metabolismMore Details
    16782174 Genetic variation in the interleukin-6 gene in relation to risk and outcomes in acute coronary syndrome.Thrombosis researchMore Details
    15171792 Elevated white cell count in acute coronary syndromes: relationship to variants in inflammatory and thrombotic genes.BMC medical geneticsMore Details
    14557872 Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients.Human geneticsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 5 unique genes interacted with IL6. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    IL6R Reconstituted Complex14557255 CHD related
    SH3GL2 Two-hybrid16169070|16169070 No
    ZBTB16 yeast 2-hybrid16169070 No
    PTHLH in vitro12000745 No
    IL6ST in vivo14557255 CHD related

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code