Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: "interleukin 6 (interferon, beta 2)"
Entrez Gene ID: 3569
SwissProt Acc Number: P05231
RefSeq: NM_000600
It was suspected to be CHD related:
.."It can also be protective in CAD patients since the reduced adiponectin-induced IL-6 release in CAD macrophages compared to controls, could be beneficial in the development of inflammation related atherosclerosis. "..
From PMID: 21626471, in Journal Horm Metab Res. , 2011There were 35 potential papers with IL6 and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 24117346 | Genetic variation and gender determine bradykinin type 1 receptor responses in human tissue: implications for the ACE-inhibitor-induced effects in patients with coronary artery disease. | "Clinical science (London, England : 1979)" | More Details |
| 24072607 | Interleukin 6(-174G/C) Variant and its Circulating Levels in Coronary Artery Disease Patients and Their First Degree Relatives. | Inflammation | More Details |
| 23906927 | Inflammation and sudden cardiac death in a community-based population of older adults: the Cardiovascular Health Study. | Heart rhythm : the official journal of the Heart Rhythm Society | More Details |
| 23121518 | TLR4 expression on monocyte subsets in myocardial infarction. | Journal of internal medicine | More Details |
| 23357300 | Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease (CAD) patients. | Cytokine | More Details |
| 23132698 | Active acromegaly is associated with decreased hs-CRP and NT-proBNP serum levels: insights from the Belgian registry of acromegaly. | European journal of endocrinology / European Federation of Endocrine Societies | More Details |
| 24134608 | The effect of statin therapy withdrawal on monocyte subsets. | European journal of clinical investigation | More Details |
| 23665315 | Vasoprotective effect of vitamin E: rescue of ethanol-induced atherosclerosis and inflammatory stress in rat vascular wall. | International immunopharmacology | More Details |
| 23881440 | Association between interleukin 6 and interleukin 16 gene polymorphisms and coronary heart disease risk in a Chinese population. | The Journal of international medical research | More Details |
| 23505291 | Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. | Circulation. Cardiovascular genetics | More Details |
| 23125512 | "Association of constitutional type of Ayurveda with cardiovascular risk factors, inflammatory markers and insulin resistance." | Journal of Ayurveda and integrative medicine | More Details |
| 22780915 | A novel multiplex polymerase chain reaction assay for profile analyses of gene expression in peripheral blood. | BMC cardiovascular disorders | More Details |
| 21130994 | Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction. | Atherosclerosis | More Details |
| 21087078 | Genetic and environmental influences on the plasma interleukin-6 concentration in patients with a recent myocardial infarction: a case-control study. | Journal of interferon & cytokine research : the official journal of the | More Details |
| 20112301 | Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats. | Molecular nutrition & food research | More Details |
| 20206549 | Interleukin-1 beta and interleukin-6 gene polymorphism associations with angiographically assessed coronary artery disease in Brazilians. | Cytokine | More Details |
| 20606121 | Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study. | Circulation | More Details |
| 20484148 | Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in macrophages from older men and postmenopausal women. | The Journal of endocrinology | More Details |
| 21152190 | Usefulness of C-reactive protein as a marker for prediction of future coronary events in the asian Indian population: Indian atherosclerosis research study. | International journal of vascular medicine | More Details |
| 18922529 | Higher IL-6 levels but not IL6 -174G>C or -572G>C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery. | Atherosclerosis | More Details |
| 19084425 | Association of IL6 and IL10 with renal dysfunction and the use of haemofiltration during cardiopulmonary bypass. | European journal of cardio-thoracic surgery : official journal of the European | More Details |
| 19008156 | Inflammatory response of coronary artery disease postmenopausal women is associated with the IVS1-397T > C estrogen receptor alpha polymorphism. | "Clinical immunology (Orlando, Fla.)" | More Details |
| 19140875 | The additive contribution from inflammatory genetic markers on the severity of cardiovascular disease. | Scandinavian journal of immunology | More Details |
| 18774574 | Polymorphism in the IL6 promoter region is associated with the risk factors and markers of subclinical atherosclerosis in men: The Cardiovascular Risk in Young Finns Study. | Atherosclerosis | More Details |
| 18356242 | Association of serum interleukin-6 concentration with a functional IL6 -6331T>C polymorphism. | Clinical chemistry | More Details |
| 18449426 | Polymorphisms in the IL6 gene in Asian Indian families with premature coronary artery disease--the Indian Atherosclerosis Research Study. | Thrombosis and haemostasis | More Details |
| 18573392 | High-dose insulin therapy attenuates systemic inflammatory response in coronary artery bypass grafting patients. | The Annals of thoracic surgery | More Details |
| 17023074 | Long-term prognosis after coronary bypass surgery depends on interleukin 6 polymorphism and past acute infections. | International journal of cardiology | More Details |
| 17661772 | Does the type of surgery effect systemic response following cardiopulmonary bypass? | Journal of cardiac surgery | More Details |
| 17130180 | "Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men." | Clinical chemistry | More Details |
| 17950688 | [Relationship between coronary artery disease and periodontal disease. What the cardiologist must know]. | Annales de cardiologie et d'angeiologie | More Details |
| 17123852 | "Association between plasma IL-6, the IL6 -174G>C gene variant and the metabolic syndrome in type 2 diabetes mellitus." | Molecular genetics and metabolism | More Details |
| 16782174 | Genetic variation in the interleukin-6 gene in relation to risk and outcomes in acute coronary syndrome. | Thrombosis research | More Details |
| 15171792 | Elevated white cell count in acute coronary syndromes: relationship to variants in inflammatory and thrombotic genes. | BMC medical genetics | More Details |
| 14557872 | Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients. | Human genetics | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 5 unique genes interacted with IL6. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| IL6R | Reconstituted Complex | 14557255 | CHD related |
| SH3GL2 | Two-hybrid | 16169070|16169070 | No |
| ZBTB16 | yeast 2-hybrid | 16169070 | No |
| PTHLH | in vitro | 12000745 | No |
| IL6ST | in vivo | 14557255 | CHD related |
| Status | DrubBank ID | Name | Indication | ATC Code |
|---|---|---|---|---|
| approved;nutraceutical | DB01404 | Ginseng |