How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: INS

    Description: insulin

    Entrez Gene ID: 3630

    SwissProt Acc Number: P01308

    RefSeq: NM_000207

    It was suspected to be CHD related:

    ..FFAs in patients with SLE are not associated with markers of generalized inflammation but are associated with insulin resistance and markers of endothelial activation...

    From PMID: 23060481, in Journal Lupus , 2013


    References

    There were 8 potential papers with INS and CHD.

    PMIDTitleJournalsDetails
    24211905 Influence of timing algorithm on brachialankle pulse wave velocity measurement.Bio-medical materials and engineeringMore Details
    23806255 Progression of asymptomatic carotid stenosis despite optimal medical therapy.Journal of vascular surgeryMore Details
    20304581 Insulin use is associated with poor limb salvage and survival in diabetic patients with chronic limb ischemia.Journal of vascular surgeryMore Details
    20580041 "Apolipoprotein C-I genotype and serum levels of triglycerides, C-reactive protein and coronary heart disease."Metabolism: clinical and experimentalMore Details
    20167924 A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease.Circulation researchMore Details
    17551966 "Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis."Clinical cardiologyMore Details
    17044869 "The effects of three factor VII polymorphisms on factor VII coagulant levels in healthy Singaporean Chinese, Malay and Indian newborns."Annals of human geneticsMore Details
    14749349 Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits.Human molecular geneticsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 21 unique genes interacted with INS. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    APP Reconstituted Complex21832049 No
    INS in vivo12021212 CHD related
    RB1 in vitro;in vivo10938588,7818556 CHD related
    IGF1R in vivo1851182 CHD related
    INSR in vivo2550426 No
    TXNDC17 Biochemical Activity14607844|14607844 No
    MLL Biochemical Activity14607844 No
    NOV Reconstituted Complex10084601 No
    IGFBP7 Reconstituted Complex9388210|9388210 No
    MAPK6 Two-hybrid21900206 No
    CRYAB Protein-peptide17487982 No
    LRP2 in vitro9773776 No
    HLA-DQB1 in vitro11376336 No
    SYTL4 in vitro10497219 No
    HLA-DQA2 in vitro11376336 No
    CPE in vivo10966857,7477119 CHD related
    CTSB in vitro6351842 CHD related
    CTSD in vitro;in vivo11779865 No
    CTSE in vitro1959628,195962 No
    GCK in vitro12101177 CHD related
    IDE in vitro11145591,17051221 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    experimentalDB01776M-Cresol
    experimentalDB08231MYRISTIC ACID