How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: INSIG1

    Description: insulin induced gene 1

    Entrez Gene ID: 3638

    SwissProt Acc Number: O15503

    RefSeq: NM_005542

    It was supported literatures to be a novel CHD related gene:

    .."The present study indicated that the INSIG1 gene, but not the INSIG2 gene, was associated with CHD in the Chinese population."..

    From PMID: 21415164, in Journal Cancer Res. , 2011


    There were 1 potential papers with INSIG1 and CHD.

    19740467 Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population.AtherosclerosisMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 19 unique genes interacted with INSIG1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    SCAP Affinity Capture-Western12842885|18835813|17043353|12242332|12842885,12202038,12482938 CHD related
    SREBF2 Affinity Capture-Western12842885|12202038|12242332 CHD related
    VCP Affinity Capture-Western18835813|16168377|19815544 No
    UBC Affinity Capture-Western16168377|19458199|17043353|19815544 No
    AMFR Affinity Capture-Western16168377|17043353|19815544|21343306 No
    HMGCR Affinity Capture-Western16168377|19458199|12535518 CHD related
    PSMC3 Reconstituted Complex19815544 No
    PSMA7 Reconstituted Complex19815544 No
    INSIG1 Affinity Capture-Western19617589 CHD related
    INSIG2 Affinity Capture-Western19617589 No
    ERLIN2 Affinity Capture-Western21343306 No
    PGRMC1 Reconstituted Complex15782218 No
    SREBF1 Affinity Capture-Western12242332 No
    Scap Affinity Capture-Western12202038 No
    FAF2 Affinity Capture-Western18835813 No
    VAPA Affinity Capture-Western16606821 No
    VAPB Affinity Capture-Western16606821 No
    RNF139 Affinity Capture-Western20068067|22143767 No
    ELAVL1 Affinity Capture-RNA19322201 No

    Involved FDA drugs

    There was no drug associated with INSIG1