How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ITGA2B

    Description: "integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)"

    Entrez Gene ID: 3674

    SwissProt Acc Number: P08514

    RefSeq: NM_000419

    It was suspected to be CHD related:

    .."The combined group samples identified 6 up regulated differential expression (DE) genes (GHRL, LTA, CBS, HP, ITGA2B, and OLR1) and 12 down regulated DE genes (IL18R1, ITGA2B, IL18RAP, HP, OLR1, SOD2 ITGB3, IL1B, MMP9, PLA2G7, UTS2, and CBS) to be involved in CAD at the fold change of 1.3 with fault discovery rate (FDR) of 1%."..

    From PMID: 22738689, in Journal J Cardiol. , 2012


    References

    There were 5 potential papers with ITGA2B and CHD.

    PMIDTitleJournalsDetails
    23831034 Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events.Journal of the American College of CardiologyMore Details
    24244288 "The Association of Four Common Polymorphisms from Four Candidate Genes (COX-1, COX-2, ITGA2B, ITGA2) with Aspirin Insensitivity: A Meta-Analysis."PloS oneMore Details
    22738689 Peripheral blood gene expression profile of atherosclerotic coronary artery disease in patients of different ethnicity in Malaysia.Journal of cardiologyMore Details
    23346430 "Deep Vein Thrombosis, Raynaud's Phenomenon, and Prinzmetal Angina in a Patient with Glanzmann Thrombasthenia."Case reports in hematologyMore Details
    17403027 The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk.Annals of human geneticsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 15 unique genes interacted with ITGA2B. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    GRB2 Reconstituted Complex8631894|11964172,8631894 CHD related
    F2 Reconstituted Complex11487023|11487023 CHD related
    COL2A1 Reconstituted Complex7520045|10772239,7520045 No
    ITGB3 in vitro;in vivo1429573,14681217,15067009,11606749 CHD related
    VWF in vitro;in vivo1737795 CHD related
    CALR in vivo14985176 No
    CIB1 in vitro;yeast 2-hybrid9030514 No
    COL1A2 in vivo11359786 CHD related
    ITGA2B in vivo14681217 CHD related
    FGA in vitro11460491 CHD related
    CLNS1A Affinity Capture-Western15075326|15075326|15075326 No
    AUP1 Affinity Capture-Western12042322|12042322|12042322 No
    CD36 Affinity Capture-Western11238109 CHD related
    RNF181 Reconstituted Complex15075326|18331836|18331836 No
    TLN1 in vitro16546176 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00054AbciximabB01AC13
    approvedDB00775Tirofiban"For treatment, in combination with heparin, of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy."B01AC17