How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ITPKC

    Description: "inositol 1,4,5-trisphosphate 3-kinase C"

    Entrez Gene ID: 80271

    SwissProt Acc Number: Q96DU7

    RefSeq: NM_025194

    It was supported literatures to be a novel CHD related gene:

    ..ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms...

    From PMID: 18084290, in Journal Nat Genet. , 2008


    References

    There were 14 potential papers with ITPKC and CHD.

    PMIDTitleJournalsDetails
    24162006 Management of Kawasaki disease.Archives of disease in childhoodMore Details
    21987091 ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease.The pharmacogenomics journalMore Details
    23894522 A replication study for association of ITPKC and CASP3 two-locus analysis in IVIG unresponsiveness and coronary artery lesion in Kawasaki disease.PloS oneMore Details
    22361738 Single-nucleotide polymorphism rs2290692 in the 3'UTR of ITPKC associated with susceptibility to Kawasaki disease in a Han Chinese population.Pediatric cardiologyMore Details
    22498790 ITPKC susceptibility in Kawasaki syndrome as a sensitizing factor for autoimmunity and coronary arterial wall relaxation induced by thimerosal's effects on calcium signaling via IP3.Autoimmunity reviewsMore Details
    23065250 "A functional polymorphism, rs28493229, in ITPKC and risk of Kawasaki disease: an integrated meta-analysis."Molecular biology reportsMore Details
    20805785 Clinical Implication of the C Allele of the ITPKC Gene SNP rs28493229 in Kawasaki Disease: Association With Disease Susceptibility and BCG Scar Reactivation.The Pediatric infectious disease journalMore Details
    22161096 [Association study of a functional SNP rs28493229 of ITPKC gene and Kawasaki disease in a Chinese population].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = ChineseMore Details
    21487896 Lack of association between ORAI1/CRACM1 gene polymorphisms and Kawasaki disease in the Taiwanese children.Journal of clinical immunologyMore Details
    20690826 Kawasaki disease: novel insights into etiology and genetic susceptibility.Annual review of medicineMore Details
    20616737 Kawasaki disease: update on pathogenesis.Current opinion in rheumatologyMore Details
    20045869 ITPKC gene SNP rs28493229 and Kawasaki disease in Taiwanese children.Human molecular geneticsMore Details
    19158812 Susceptibility genes for Kawasaki disease: toward implementation of personalized medicine.Journal of human geneticsMore Details
    18084290 ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms.Nature geneticsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There was NO PPI interaction information about ITPKC



    Involved FDA drugs

    There was no drug associated with ITPKC