How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.
The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

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  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

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  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.

    • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: KIF6

    Description: kinesin family member 6

    Entrez Gene ID: 221458

    SwissProt Acc Number: Q6ZMV9

    RefSeq: NM_145027

    It was supported literatures to be a novel CHD related gene:

    .."Recently,multiple large studies consisting mainly of Europeans have shown that KIF6 Trp719Arg SNP may be a new predictive factor for coronary artery disease (CAD) event risk."..

    From PMID: 23001387, in Journal Molecules. , 2012


    References

    There were 18 potential papers with KIF6 and CHD.

    PMIDTitleJournalsDetails
    22192511 "KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly."AtherosclerosisMore Details
    23236363 Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect.PloS oneMore Details
    23001387 Association of KIF6 variant with lipid level and angiographic coronary artery disease events risk in the Han Chinese population."Molecules (Basel, Switzerland)"More Details
    20886236 Genetic variants in the KIF6 region and coronary event reduction from statin therapy.Human geneticsMore Details
    21810021 Investigation of KIF6 Trp719Arg in a case-control study of coronary artery disease in Western Indians.Genetic testing and molecular biomarkersMore Details
    21435211 Survival bias and drug interaction can attenuate cross-sectional case-control comparisons of genes with health outcomes. An example of the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism and coronary heart disease.BMC medical geneticsMore Details
    21406102 "The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study."BMC cardiovascular disordersMore Details
    20854963 KIF6 polymorphism as a predictor of risk of coronary events and of clinical event reduction by statin therapy.The American journal of cardiologyMore Details
    20933357 Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.Journal of the American College of CardiologyMore Details
    20403483 Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial.The American journal of cardiologyMore Details
    20215968 KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study.European journal of cardiovascular prevention and rehabilitation : officialMore Details
    20975779 KIF6 p.Trp719Arg Testing to Assess Risk of Coronary Artery Disease and/or Statin Response.PLoS currentsMore Details
    19752551 Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry."Cerebrovascular diseases (Basel, Switzerland)"More Details
    18222354 A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study.Journal of the American College of CardiologyMore Details
    18222353 Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.Journal of the American College of CardiologyMore Details
    18222355 Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study.Journal of the American College of CardiologyMore Details
    17975119 Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study."Arteriosclerosis, thrombosis, and vascular biology"More Details
    18073581 Five common gene variants identify elevated genetic risk for coronary heart disease.Genetics in medicine : official journal of the American College of MedicalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 2 unique genes interacted with KIF6. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    APPBP2 Two-hybrid16189514|16189514 No
    SIRT5 Positive Genetic22318606 No


    Involved FDA drugs

    There was no drug associated with KIF6