How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: LILRB1

    Description: "leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1"

    Entrez Gene ID: 10859

    SwissProt Acc Number: Q8NHL6

    RefSeq: NM_001081637

    It was supported literatures to be a novel CHD related gene:

    .."The association of overt and subclinical atherosclerotic disease with LILRB1+ NK and T-cells likely reflects a relationship between the immune challenge by infections and cardiovascular disease risk, without attributing a dominant role for HCMV. Our findings may lead to the identification of novel biomarkers of vascular disease."..

    From PMID: 21817101, in Journal Arterioscler Thromb Vasc Biol. , 2011


    There were 1 potential papers with LILRB1 and CHD.

    21817101 Association of atherosclerosis with expression of the LILRB1 receptor by human NK and T-cells supports the infectious burden hypothesis."Arteriosclerosis, thrombosis, and vascular biology"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 7 unique genes interacted with LILRB1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    HLA-A Co-crystal Structure12897781|12897781 No
    HLA-B Reconstituted Complex12853576|12853576 No
    HLA-C Reconstituted Complex12853576|12853576 No
    HLA-G Reconstituted Complex12853576|9933109,12853576,12874224 No
    HLA-F Reconstituted Complex11169396|11169396 No
    PTPN6 Affinity Capture-Western9842885 No
    B2M in vitro12897781 CHD related

    Involved FDA drugs

    There was no drug associated with LILRB1