How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: LPA

    Description: "lipoprotein, Lp(a)"

    Entrez Gene ID: 4018

    SwissProt Acc Number: P08519

    RefSeq: NM_005577

    It was suspected to be CHD related:

    .."LPA, the gene coding for apolipoprotein(a) [apo(a)], is the major determinant of lipoprotein(a) [Lp(a)] plasma levels, which are associated with risk for coronary heart disease (CHD) and stroke."..

    From PMID: 15523644, in Journal Hum Mutat. , 2004


    References

    There were 49 potential papers with LPA and CHD.

    PMIDTitleJournalsDetails
    24056686 "Lipoprotein Apheresis in Patients with Maximally Tolerated Lipid Lowering Therapy, Lp(a)-Hyperlipoproteinemia and Progressive Cardiovascular Disease: Prospective Observational Multicenter Study."CirculationMore Details
    23735648 Validation and quantification of genetic determinants of lipoprotein-a levels and predictive value for angiographic coronary artery disease.The American journal of cardiologyMore Details
    23881580 Genetics of lipid traits and relationship to coronary artery disease.Current cardiology reportsMore Details
    23903772 Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment.Pharmacogenetics and genomicsMore Details
    23375930 Extreme lipoprotein(a) levels and improved cardiovascular risk prediction.Journal of the American College of CardiologyMore Details
    23664202 Increased lysophosphatidic acid levels in culprit coronary arteries of patients with acute coronary syndrome.AtherosclerosisMore Details
    23653095 Positive correlation between variants of lipid metabolismrelated genes and coronary heart disease.Molecular medicine reportsMore Details
    22998429 Lipoprotein(a): resurrected by genetics.Journal of internal medicineMore Details
    23278389 Two rare variants explain association with acute myocardial infarction in an extended genomic region including the apolipoprotein(A) gene.Annals of human geneticsMore Details
    23978127 Lack of association between lipoprotein(a) genetic variants and subsequent cardiovascular events in Chinese Han patients with coronary artery disease after percutaneous coronary intervention.Lipids in health and diseaseMore Details
    22740131 Developmental changes in lysophospholipid receptor expression in rodent heart from near-term fetus to adult.Molecular biology reportsMore Details
    22516069 Genetic evidence that lipoprotein(a) associates with atherosclerotic stenosis rather than venous thrombosis."Arteriosclerosis, thrombosis, and vascular biology"More Details
    21900290 "Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes."European heart journalMore Details
    22192511 "KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly."AtherosclerosisMore Details
    22898070 Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism.Journal of the American College of CardiologyMore Details
    22327610 Lipoprotein(a): more interesting than ever after 50 years.Current opinion in lipidologyMore Details
    23107424 High-resolution motion compensated MRA in patients with congenital heart disease using extracellular contrast agent at 3 Tesla.Journal of cardiovascular magnetic resonance : official journal of the SocietyMore Details
    23230442 "Association study of lipoprotein(a) genetic markers, traditional risk factors, and coronary heart disease in HIV-1-infected patients."Frontiers in immunologyMore Details
    21966275 Large-scale gene-centric analysis identifies novel variants for coronary artery disease.PLoS geneticsMore Details
    21889313 Chlamydia pneumoniae heat shock protein 60 is associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients.Journal of cardiologyMore Details
    21596318 Emerging genomic applications in coronary artery disease.JACC. Cardiovascular interventionsMore Details
    21127300 "Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk."Stroke; a journal of cerebral circulationMore Details
    21252144 Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study.Circulation. Cardiovascular geneticsMore Details
    21749171 Lipoprotein(a): genotype-phenotype relationship and impact on atherogenic risk.Metabolic syndrome and related disordersMore Details
    21283670 Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans.PloS oneMore Details
    20605575 Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus.AtherosclerosisMore Details
    20435227 Clinical assessment incorporating a personal genome.LancetMore Details
    19880117 The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles.AtherosclerosisMore Details
    19623058 Lipoprotein(a): a causal independent risk factor for coronary heart disease?Current opinion in cardiologyMore Details
    19787726 First-pass and steady-state magnetic resonance angiography of the thoracic vasculature using gadofosveset trisodium.Journal of magnetic resonance imaging : JMRIMore Details
    19629575 Completion angiography after cardiac surgery for congenital heart disease: complementing the intraoperative imaging modalities.Pediatric cardiologyMore Details
    19322601 Factor analysis of markers of inflammation and oxidation and echocardiographic findings in children with a positive family history of premature coronary heart disease.Pediatric cardiologyMore Details
    20032323 Genetic variants associated with Lp(a) lipoprotein level and coronary disease.The New England journal of medicineMore Details
    18046597 Cord blood lipid profile in a population of Iranian term newborns.Pediatric cardiologyMore Details
    18202325 Individual heterogeneity in platelet response to lysophosphatidic acid: evidence for a novel inhibitory pathway."Arteriosclerosis, thrombosis, and vascular biology"More Details
    18068195 Enhanced sterol response element-binding protein in postintervention restenotic blood vessels plays an important role in vascular smooth muscle proliferation.Life sciencesMore Details
    17975119 Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study."Arteriosclerosis, thrombosis, and vascular biology"More Details
    20300231 Balloon pulmonary valvotomy as interim palliation for symptomatic young infants with tetralogy of Fallot.Annals of pediatric cardiologyMore Details
    18612205 LPA and PLG sequence variation and kringle IV-2 copy number in two populations.Human heredityMore Details
    18682748 "Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction."PloS oneMore Details
    17569884 A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16840570 Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein(a) level elevation in African Americans compared with European Americans.Journal of medical geneticsMore Details
    16575266 ESC Study Group of Sports Cardiology: recommendations for participation in leisure-time physical activity and competitive sports for patients with ischaemic heart disease.European journal of cardiovascular prevention and rehabilitation : officialMore Details
    16181881 "En bloc exclusion of the pulmonary vein region in the pig using off pump, beating, intra-cardiac surgery: a pilot study of minimally invasive surgery for atrial fibrillation."The Annals of thoracic surgeryMore Details
    16258736 Factors associated with type 1 diabetes in Kuwaiti children.Acta diabetologicaMore Details
    16446851 [Coronary biomarkers and long-term clinical outcome in acute coronary syndrome without ST segment elevation].Revista medica de ChileMore Details
    15670038 GPIIb-IIIa antagonists reduce thromboinflammatory processes in patients with acute coronary syndromes undergoing percutaneous coronary intervention.Journal of thrombosis and haemostasis : JTHMore Details
    15523644 A common nonsense mutation in the repetitive Kringle IV-2 domain of human apolipoprotein(a) results in a truncated protein and low plasma Lp(a).Human mutationMore Details
    12806020 "Lysophospholipid growth factors and their G protein-coupled receptors in immunity, coronary artery disease, and cancer."TheScientificWorldJournalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 9 unique genes interacted with LPA. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    FN1 Reconstituted Complex2531657|2531657|2531657 CHD related
    FGB Reconstituted Complex10980194|10980194|10980194 CHD related
    CANX Affinity Capture-Western9717723|12562843 No
    LRP2 Reconstituted Complex10073957|10073957 No
    APOH in vitro9269765 CHD related
    CELA1 in vitro8864963,9111002 CHD related
    ELANE in vitro8864963,9111002 CHD related
    MMP12 in vitro10187779 CHD related
    FBLN5 in vivo;yeast 2-hybrid12111551 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00513Aminocaproic AcidFor use in the treatment of excessive postoperative bleeding.B02AA01