How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: LPL

    Description: lipoprotein lipase

    Entrez Gene ID: 4023

    SwissProt Acc Number: P06858

    RefSeq: NM_000237

    It was suspected to be CHD related:

    ..LPL (lipoprotein lipase) is the key enzyme in triacylglycerol (triglyceride) hydrolysis and supplies FAs to the heart..

    From PMID: 17291198, in Journal Clin Sci (Lond) , 2007


    References

    There were 103 potential papers with LPL and CHD.

    PMIDTitleJournalsDetails
    24065391 Evaluation of the anti-atherogenic potential of chrysin in Wistar rats.Molecular and cellular biochemistryMore Details
    22727960 Brown fat like gene expression in the epicardial fat depot correlates with circulating HDL-cholesterol and triglycerides in patients with coronary artery disease.International journal of cardiologyMore Details
    23902956 A lipoprotein lipase gene polymorphism interacts with consumption of alcohol and unsaturated fat to modulate serum HDL-cholesterol concentrations.The Journal of nutritionMore Details
    23505323 Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.Journal of medical geneticsMore Details
    23377670 Synergistic effect between lipoprotein lipase and apolipoprotein C3 genes in determining the severity of coronary artery disease.Journal of cardiovascular translational researchMore Details
    23666884 Diagnosis and management of familial dyslipoproteinemias.Current cardiology reportsMore Details
    22729917 "Six lipoprotein lipase gene polymorphisms, lipid profile and coronary stenosis in a Tunisian population."Molecular biology reportsMore Details
    22024251 Lipoprotein lipase mediated fatty acid delivery and its impact in diabetic cardiomyopathy.Biochimica et biophysica actaMore Details
    21621348 [Association between variants of lipoprotein lipase and coronary heart disease in a Tunisian population].Pathologie-biologieMore Details
    22100250 Expression of fat mobilizing genes in human epicardial adipose tissue.AtherosclerosisMore Details
    21804106 "Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration."European heart journalMore Details
    22837712 DNA polymorphisms of the lipoprotein lipase gene and their association with coronary artery disease in the saudi population.International journal of molecular sciencesMore Details
    22952570 "Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol."PloS oneMore Details
    21889313 Chlamydia pneumoniae heat shock protein 60 is associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients.Journal of cardiologyMore Details
    21252727 Contribution of adiponectin to the cardiometabolic risk of postmenopausal women with loss-of-function lipoprotein lipase gene mutations."Menopause (New York, N.Y.)"More Details
    22229114 Common Variants in 6 Lipid-Related Genes Discovered by High-Resolution DNA Melting Analysis and Their Association with Plasma Lipids.Journal of clinical & experimental cardiologyMore Details
    21127884 The S447X variant of lipoprotein lipase gene is inversely associated with severity of coronary artery disease.Heart and vesselsMore Details
    21130994 Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction.AtherosclerosisMore Details
    22042884 Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.Circulation. Cardiovascular geneticsMore Details
    22018640 Eicosapentaenoic acid administration attenuates the pro-inflammatory properties of VLDL by decreasing its susceptibility to lipoprotein lipase in macrophages.AtherosclerosisMore Details
    21960661 Hepatic lipase gene -514C>T variant is associated with exercise training-induced changes in VLDL and HDL by lipoprotein lipase."Journal of applied physiology (Bethesda, Md. : 1985)"More Details
    21120692 Hypertriglyceridemia and delayed clearance of fat load in transgenic rabbits expressing human apolipoprotein CIII.Transgenic researchMore Details
    21646389 Severity of diabetes governs vascular lipoprotein lipase by affecting enzyme dimerization and disassembly.DiabetesMore Details
    21252261 Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study.Journal of lipid researchMore Details
    21347282 "Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project."PLoS geneticsMore Details
    20650961 Application of statistical and functional methodologies for the investigation of genetic determinants of coronary heart disease biomarkers: lipoprotein lipase genotype and plasma triglycerides as an exemplar.Human molecular geneticsMore Details
    21122694 Dyslipidemia and lipoprotein profiles in patients with inflammatory bowel disease.Journal of clinical lipidologyMore Details
    20864672 Genetic variants influencing circulating lipid levels and risk of coronary artery disease."Arteriosclerosis, thrombosis, and vascular biology"More Details
    20410100 "Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan Eskimos."The American journal of clinical nutritionMore Details
    22460205 "Genetic variants at the APOE, lipoprotein lipase (LpL), cholesteryl ester transfer protein (CETP), and endothelial nitric oxide (eNOS) genes and coronary artery disease (CAD): CETP Taq1 B2B2 associates with lower risk of CAD in Asian Indians."Journal of community geneticsMore Details
    20434407 Update on genetics of postprandial lipemia.Atherosclerosis. SupplementsMore Details
    20430250 Associations for lipoprotein lipase and peroxisome proliferator-activated receptor-gamma gene and coronary artery disease in an Indian population.Archives of medical researchMore Details
    19639021 The common biological basis for common complex diseases: evidence from lipoprotein lipase gene.European journal of human genetics : EJHGMore Details
    19876761 Protective modulation of carotid atherosclerosis in hyperalphalipoproteinemic individuals.The international journal of cardiovascular imagingMore Details
    20150529 Associations of lipoprotein lipase gene polymorphisms with longitudinal plasma lipid trends in young adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study.Circulation. Cardiovascular geneticsMore Details
    20056168 Modulation of plasma TG lipolysis by Angiopoietin-like proteins and GPIHBP1.Biochimica et biophysica actaMore Details
    18823627 "Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes: the genetics, outcomes, and lipids in type 2 diabetes (GOLD) study."AtherosclerosisMore Details
    19336475 Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.Human molecular geneticsMore Details
    19185650 "S447X variant of the lipoprotein lipase gene, lipids, and risk of coronary heart disease in 3 prospective cohort studies."American heart journalMore Details
    19218500 Endothelial heparanase secretion after acute hypoinsulinemia is regulated by glucose and fatty acid.American journal of physiology. Heart and circulatory physiologyMore Details
    19191728 "Preheparin serum lipoprotein lipase mass interacts with gender, gene polymorphism and, positively, with smoking."Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    19878569 Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.BMC medical geneticsMore Details
    18242618 Functional significance of lipoprotein lipase HindIII polymorphism associated with the risk of coronary artery disease.AtherosclerosisMore Details
    18603482 Influence of genetic factors in the modulation of postprandial lipemia.Atherosclerosis. SupplementsMore Details
    18389299 Increased postprandial triglyceride-rich lipoprotein levels in elderly survivors of myocardial infarction.LipidsMore Details
    18068174 Genetic screening of the LPL gene in hypertriglyceridaemic patients.AtherosclerosisMore Details
    18704761 Molecular genetics of myocardial infarction.Genomic medicineMore Details
    17942824 Acute diabetes moderates trafficking of cardiac lipoprotein lipase through p38 mitogen-activated protein kinase-dependent actin cytoskeleton organization.DiabetesMore Details
    18032735 Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet.Circulation researchMore Details
    18193043 Newly identified loci that influence lipid concentrations and risk of coronary artery disease.Nature geneticsMore Details
    18922999 "Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis."American journal of epidemiologyMore Details
    18974381 "ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk.""Arteriosclerosis, thrombosis, and vascular biology"More Details
    18415697 Apoprotein A-V: an important regulator of triglyceride metabolism.Journal of inherited metabolic diseaseMore Details
    17403027 The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk.Annals of human geneticsMore Details
    17223095 Serum lipoprotein lipase mass: clinical significance of its measurement.Clinica chimica acta; international journal of clinical chemistryMore Details
    17291198 The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease."Clinical science (London, England : 1979)"More Details
    17130180 "Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men."Clinical chemistryMore Details
    17259402 Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease.DiabetesMore Details
    16755277 Haplotypes in the lipoprotein lipase gene influence high-density lipoprotein cholesterol response to statin therapy and progression of atherosclerosis in coronary artery bypass grafts.The pharmacogenomics journalMore Details
    17562973 Angiotensin-converting enzyme genotype interacts with systolic blood pressure to determine coronary heart disease risk in healthy middle-aged men.HypertensionMore Details
    17721767 Lipoprotein lipase HindIII polymorphism influences HDL-cholesterol levels in statin-treated patients with coronary artery disease.Wiener klinische WochenschriftMore Details
    17484619 Association of lipase lipoprotein polymorphisms with myocardial infarction and lipid levels.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    17883852 Homozygous missense mutation (G56R) in glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPI-HBP1) in two siblings with fasting chylomicronemia (MIM 144650).Lipids in health and diseaseMore Details
    16965549 A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology.The European journal of neuroscienceMore Details
    16769999 "Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study."Journal of lipid researchMore Details
    16741292 A systematic review and meta-analysis of the relationship between lipoprotein lipase Asn291Ser variant and diseases.Journal of lipid researchMore Details
    17001213 Relationship of classical and non-classical risk factors with genetic variants relevant to coronary heart disease.European journal of cardiovascular prevention and rehabilitation : officialMore Details
    16373616 Serum lipoprotein lipase concentration and risk for future coronary artery disease: the EPIC-Norfolk prospective population study."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16458317 Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice.AtherosclerosisMore Details
    16763159 Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16477380 "Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice."Molecular and cellular biochemistryMore Details
    16776623 Polymorphisms associated with apolipoprotein B levels in Greek patients with familial hypercholesterolemia.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    16822320 The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion.Lipids in health and diseaseMore Details
    16938803 Unraveling the complex genetics of familial combined hyperlipidemia.Annals of medicineMore Details
    16131150 Effects of oleic acid rich oils on aorta lipids and lipoprotein lipase activity of spontaneously hypertensive rats.Journal of agricultural and food chemistryMore Details
    16168296 Lipoprotein lipase gene polymorphisms and the risk of target vessel revascularization after percutaneous coronary intervention.Journal of the American College of CardiologyMore Details
    16002740 Complete rescue of lipoprotein lipase-deficient mice by somatic gene transfer of the naturally occurring LPLS447X beneficial mutation."Arteriosclerosis, thrombosis, and vascular biology"More Details
    15910848 Differential uptake of subfractions of triglyceride-rich lipoproteins by THP-1 macrophages.AtherosclerosisMore Details
    16086925 Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease.American heart journalMore Details
    15928243 The 3' untranslated region of the lipoprotein lipase gene: haplotype structure and association with post-heparin plasma lipase activity.The Journal of clinical endocrinology and metabolismMore Details
    15657615 Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD.European journal of human genetics : EJHGMore Details
    15356086 The influence of lipoprotein lipase gene variation on postprandial lipoprotein metabolism.The Journal of clinical endocrinology and metabolismMore Details
    15292370 Polymorphisms in the gene encoding lipoprotein lipase in men with low HDL-C and coronary heart disease: the Veterans Affairs HDL Intervention Trial.Journal of lipid researchMore Details
    15115692 Missense mutation W86R in exon 3 of the lipoprotein lipase gene in a boy with chylomicronemia.Clinica chimica acta; international journal of clinical chemistryMore Details
    15135251 Genetic polymorphisms affecting the phenotypic expression of familial hypercholesterolemia.AtherosclerosisMore Details
    15189363 Lipoprotein lipase gene variants and progression of nephropathy in hypercholesterolaemic patients with type 2 diabetes.Journal of internal medicineMore Details
    15270617 Lipoprotein lipase gene polymorphism and lipid profile in coronary artery disease.Archives of pathology & laboratory medicineMore Details
    12964943 "Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD."BMC medical geneticsMore Details
    12812518 Exaggerated postprandial lipaemia and lower post-heparin lipoprotein lipase activity in middle-aged men."Clinical science (London, England : 1979)"More Details
    14580165 Common variants in the lipoprotein lipase gene in Brazil: association with lipids and angiographically assessed coronary atherosclerosis.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    14580156 A common truncated variant of lipoprotein lipase in the Japanese population is characterized by pattern B phenotype.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    12708905 Lack of association of lipoprotein lipase gene polymorphisms with coronary artery disease in the Saudi Arab population.Archives of pathology & laboratory medicineMore Details
    12865761 Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans.Genetics in medicine : official journal of the American College of MedicalMore Details
    14685668 [Lipoprotein lipase-mediated myopathy: implications for lipid metabolism and atherogenesis]."Medizinische Klinik (Munich, Germany : 1983)"More Details
    12747600 Lipoprotein lipase gene polymorphisms in Croatian patients with coronary artery disease.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    12169766 "Induction of lipoprotein lipase gene expression in 3T3-L1 preadipocytes by atorvastatin, a cholesterol- and triglyceride-lowering drug."PharmacologyMore Details
    12200638 Angiotensin inhibition and coronary autoregulation in a canine model of LV hypertrophy.Basic research in cardiologyMore Details
    12174215 Genetic and environmental determinants of plasma high density lipoprotein cholesterol and apolipoprotein AI concentrations in healthy middle-aged men.Annals of human geneticsMore Details
    12112572 Lipoprotein lipase and APOE/APOC-I/APOC-II gene cluster diversity in native Brazilian populations.American journal of human biology : the official journal of the Human BiologyMore Details
    12806020 "Lysophospholipid growth factors and their G protein-coupled receptors in immunity, coronary artery disease, and cancer."TheScientificWorldJournalMore Details
    11702219 Physical activity modulates the combined effect of a common variant of the lipoprotein lipase gene and smoking on serum triglyceride levels and high-density lipoprotein cholesterol in men.Human geneticsMore Details
    11230170 A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation.Genome researchMore Details
    10723106 Frequency and allelic association of common variants in the lipoprotein lipase gene in different ethnic groups: the Wandsworth Heart and Stroke Study.Genetic epidemiologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 19 unique genes interacted with LPL. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    UBE2Z Two-hybrid16169070|16169070 No
    COPS6 Two-hybrid16169070|16169070 No
    KIAA1377 Two-hybrid16169070|16169070 No
    LUC7L2 Two-hybrid16169070|16169070 No
    VLDLR Reconstituted Complex7592875|7592875 No
    LRP1 Reconstituted Complex7510694|7989348|1281473,7510694,7989348 CHD related
    APP Reconstituted Complex21832049 No
    CETP in vivo9374130 CHD related
    LPL in vitro14570890 CHD related
    CALR in vivo12740382 No
    EMD Two-hybrid12755701 No
    ASCC2 Two-hybrid16169070 No
    RPL18A Two-hybrid16169070 No
    PTPN4 Two-hybrid16169070 No
    APOC2 Reconstituted Complex10727238|10727238,11579204 CHD related
    LRP2 Reconstituted Complex7686151|7686151 No
    PLK1 Affinity Capture-MS19596235 No
    UBC Affinity Capture-MS21139048 No
    CUL3 Affinity Capture-MS21145461 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB06439Tyloxapol"Used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions, administered by inhalation through a nebulizer or with a stream of oxygen. Also investigated for use/treatment in cystic fibrosis and pediatric indications."R05CA01