How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: MEF2A

    Description: myocyte enhancer factor 2A

    Entrez Gene ID: 4205

    SwissProt Acc Number: Q02078

    RefSeq: NM_001130926

    It was suspected to be CHD related:

    .."One disease-causing gene for CAD and MI has been identified as MEF2A, which is located on chromosome 15q26.3 and encodes a transcriptional factor with a high level of expression in coronary endothelium."..

    From PMID: 15811259, in Journal Curr Atheroscler Rep , 2005


    References

    There were 18 potential papers with MEF2A and CHD.

    PMIDTitleJournalsDetails
    23461724 Analysis of MEF2A mutations in a Chinese population with premature coronary artery disease.Genetic testing and molecular biomarkersMore Details
    22028303 "The effects of myocyte enhancer factor 2A gene on the proliferation, migration and phenotype of vascular smooth muscle cells."Cell biochemistry and functionMore Details
    22363637 "Variants in exon 11 of MEF2A gene and coronary artery disease: evidence from a case-control study, systematic review, and meta-analysis."PloS oneMore Details
    21450604 Exon 11 deletion in the myocyte enhancer factor (MEF)2A and early onset coronary artery disease gene in a Sicilian family.European journal of cardiovascular prevention and rehabilitation : officialMore Details
    19782985 A study of the role of the Myocyte-specific Enhancer Factor-2A gene in coronary artery disease.AtherosclerosisMore Details
    19153100 CAG repeat polymorphism of the MEF2A gene is not associated with the risk of coronary artery disease among Taiwanese.Clinical and applied thrombosis/hemostasis : official journal of theMore Details
    20546016 Structural changes in exon 11 of MEF2A are not related to sporadic coronary artery disease in Han Chinese population.European journal of clinical investigationMore Details
    20031581 Association and functional analyses of MEF2A as a susceptibility gene for premature myocardial infarction and coronary artery disease.Circulation. Cardiovascular geneticsMore Details
    18472352 Is coronary artery disease a multifactorial inherited disorder with a sex-influenced trait?Medical hypothesesMore Details
    18086930 Lack of association between the MEF2A gene and myocardial infarction.CirculationMore Details
    17579569 Relationship of the CAG repeat polymorphism of the MEF2A gene and coronary artery disease in a Chinese population.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    15958500 The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction.Journal of medical geneticsMore Details
    17945659 Soluble CD40L versus myocyte enhancer factor: predicting a prominent marker for cardiovascular disease.Conference proceedings : ... Annual International Conference of the IEEEMore Details
    15841183 Lack of MEF2A mutations in coronary artery disease.The Journal of clinical investigationMore Details
    15841171 MEF2A sequence variants and coronary artery disease: a change of heart?The Journal of clinical investigationMore Details
    15496429 Transcription factor MEF2A mutations in patients with coronary artery disease.Human molecular geneticsMore Details
    14645853 Mutation of MEF2A in an inherited disorder with features of coronary artery disease."Science (New York, N.Y.)"More Details
    14657507 Coronary artery disease and the MEF2A transcription factor.Science of aging knowledge environment : SAGE KEMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 28 unique genes interacted with MEF2A. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    THRA Reconstituted Complex12371907|12371907 CHD related
    EP300 Reconstituted Complex12371907|12371907 CHD related
    HDAC5 Affinity Capture-Western10748098|10748098|12626519 No
    SMAD2 Affinity Capture-Western11160896 CHD related
    MEF2D Co-localization8798771|8798771 No
    HDAC7 Reconstituted Complex16980305|20590529 No
    HDAC1 Affinity Capture-Western20590529 CHD related
    SUMO1 Reconstituted Complex19684601|19684601|16484498 No
    TEAD1 in vitro12061776,12861002 No
    MEF2A in vitro8575763 CHD related
    MYOD1 in vitro;in vivo9418854,8548800 No
    VGLL4 Two-hybrid15140898 No
    HDAC4 Affinity Capture-Western10487761|10487761|10487761,11792813 CHD related
    HDAC9 Affinity Capture-Western10487761|10825153 No
    MAPK14 Biochemical Activity9858528|10330143|10330143,9858528,10849446 CHD related
    ASCL1 Affinity Capture-Western8662987|8900141 No
    MYOG Reconstituted Complex1329097 No
    MAPK7 Affinity Capture-Western9753748|9753748,10849446,9858528 No
    ACTN4 Affinity Capture-Western16980305|16980305 No
    SUMO2 Affinity Capture-MS21693764 No
    UBC Affinity Capture-MS21890473|21906983 No
    HNRNPA1 Affinity Capture-MS22446626 No
    UBE2I Biochemical Activity19684601|19684601 No
    CASP3 in vitro;in vivo11904443 CHD related
    CASP7 in vitro11904443 CHD related
    SMAD4 in vitro;in vivo11160896 No
    CDK5 in vitro;in vivo12691662 No
    PHB2 in vivo15173318 No


    Involved FDA drugs

    There was no drug associated with MEF2A