How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: MPO

    Description: myeloperoxidase

    Entrez Gene ID: 4353

    SwissProt Acc Number: P05164

    RefSeq: NM_000250

    It was suspected to be CHD related:

    ..Elevated levels of leukocyte- and blood-MPO are associated with the presence of CAD...

    From PMID: 11694155, in Journal JAMA. , 2001


    References

    There were 121 potential papers with MPO and CHD.

    PMIDTitleJournalsDetails
    24057419 Is there a clinical role for oxidative stress biomarkers in atherosclerotic diseases?Internal and emergency medicineMore Details
    23869443 Trans-vessel gradient of myeloperoxidase in coronary artery disease.European journal of clinical investigationMore Details
    24112082 The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction.The Biochemical journalMore Details
    24036021 The myeloperoxidase -463G/A polymorphism and coronary artery disease risk: A meta-analysis of 1938 cases and 1990 controls.Clinical biochemistryMore Details
    23583798 Myeloperoxidase G-463A polymorphism and susceptibility to coronary artery disease: a meta-analysis.GeneMore Details
    23592614 Beneficial effect of prolonged heme oxygenase 1 activation in a rat model of chronic heart failure.Disease models & mechanismsMore Details
    22913380 Treatment with cardiotonic pills((R)) after ischemia-reperfusion ameliorates myocardial fibrosis in rats."Microcirculation (New York, N.Y. : 1994)"More Details
    22947272 Matrix metalloproteinase-9 (MMP-9) and myeloperoxidase (MPO) levels in patients with nonobstructive coronary artery disease detected by coronary computed tomographic angiography.Academic radiologyMore Details
    24316393 Increased Plasma High-sensitivity C-reactive Protein and Myeloperoxidase Levels May Predict Ischemia During Myocardial Perfusion Imaging in Slow Coronary Flow.Archives of medical researchMore Details
    24267244 Gender-specific correlation between plasma myeloperoxidase levels and serum high-density lipoprotein-associated paraoxonase-1 levels in patients with stable and unstable coronary artery disease.AtherosclerosisMore Details
    24267251 Liberation of vessel-adherent myeloperoxidase reflects plaque burden in patients with stable coronary artery disease.AtherosclerosisMore Details
    23620142 Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.Human molecular geneticsMore Details
    23771691 Endothelial cells overexpressing IL-8 receptor reduce cardiac remodeling and dysfunction following myocardial infarction.American journal of physiology. Heart and circulatory physiologyMore Details
    23670230 Association of biomarkers of lipid modification with functional and morphological indices of coronary stenosis severity in stable coronary artery disease.Journal of cardiovascular translational researchMore Details
    22580631 Aging might augment reactive oxygen species (ROS) formation and affect reactive nitrogen species (RNS) level after myocardial ischemia/reperfusion in both humans and rats."Age (Dordrecht, Netherlands)"More Details
    23645243 [Change of serum myeloperoxidase and lipoxin A4 level in coronary heart disease patients with anxiety and/or depression].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University.More Details
    22923422 Diagnostic and prognostic performance of myeloperoxidase plasma levels compared with sensitive troponins in patients admitted with acute onset chest pain.Circulation. Cardiovascular geneticsMore Details
    23003332 Combined polymorphisms in oxidative stress genes predict coronary artery disease and oxidative stress in coronary angiography patients.Annals of human geneticsMore Details
    22214747 Myeloperoxidase-derived oxidants inhibit sarco/endoplasmic reticulum Ca2+-ATPase activity and perturb Ca2+ homeostasis in human coronary artery endothelial cells.Free radical biology & medicineMore Details
    22240493 Erythrocyte-rich thrombus aspirated from patients with ST-elevation myocardial infarction: association with oxidative stress and its impact on myocardial reperfusion.European heart journalMore Details
    22344601 Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.The Journal of pathologyMore Details
    22407325 Myeloperoxidase production by macrophage and risk of atherosclerosis.Current atherosclerosis reportsMore Details
    22495256 Serum myeloperoxidase is independent of the risk factors of atherosclerosis.Coronary artery diseaseMore Details
    22024218 "Circulating adhesion molecules, matrix metalloproteinase-9, plasminogen activator inhibitor-1, and myeloperoxidase in coronary artery disease patients with stable and unstable angina."Clinica chimica acta; international journal of clinical chemistryMore Details
    21535251 Myeloperoxidase is associated with incident coronary heart disease independently of traditional risk factors: results from the MONICA/KORA Augsburg study.Journal of internal medicineMore Details
    22537345 The association of serum neutrophil markers and acute coronary syndrome.Scandinavian journal of immunologyMore Details
    23216991 Serum protein profiles predict coronary artery disease in symptomatic patients referred for coronary angiography.BMC medicineMore Details
    22761804 An intense and short-lasting burst of neutrophil activation differentiates early acute myocardial infarction from systemic inflammatory syndromes.PloS oneMore Details
    21501700 Impact of HDL oxidation by the myeloperoxidase system on sterol efflux by the ABCA1 pathway.Journal of proteomicsMore Details
    21981456 Limited value of novel pulmonary embolism biomarkers in patients with coronary atherosclerosis.Clinical physiology and functional imagingMore Details
    22120783 [Myeloperoxidase as possible diagnostic and prognostic marker of acute coronary syndrome].Recenti progressi in medicinaMore Details
    21388659 Activated inflammatory cells participate in thrombus size through tissue factor and plasminogen activator inhibitor-1 in acute coronary syndrome: Immunohistochemical analysis.Thrombosis researchMore Details
    21459139 Sophocarpine administration preserves myocardial function from ischemia-reperfusion in rats via NF-kappaB inactivation.Journal of ethnopharmacologyMore Details
    21657847 Elevated plasma myeloperoxidase levels in relation to circulating inflammatory markers in coronary artery disease.Biomarkers in medicineMore Details
    21226709 Diagnostic efficacy of myeloperoxidase for the detection of acute coronary syndromes.European journal of clinical investigationMore Details
    20223535 Independent and additive predictive value of total cholesterol content of erythrocyte membranes with regard to coronary artery disease clinical presentation.International journal of cardiologyMore Details
    21779191 "Diagnostic performance of high-sensitivity troponin T, myeloperoxidase, and pregnancy-associated plasma protein A assays for triage of patients with acute myocardial infarction."The Korean journal of laboratory medicineMore Details
    20869358 Myeloperoxidase is not associated with scintigraphic myocardial perfusion abnormalities in type 2 diabetic patients with mild stable anginal complaints.Clinica chimica acta; international journal of clinical chemistryMore Details
    21059827 Plasma myeloperoxidase predicts incident cardiovascular risks in stable patients undergoing medical management for coronary artery disease.Clinical chemistryMore Details
    20833483 Lipoxin A4 may function as an endogenous anti-arrhythmic molecule.Medical hypothesesMore Details
    20739159 Protective roles of cornuside in acute myocardial ischemia and reperfusion injury in rats.Phytomedicine : international journal of phytotherapy and phytopharmacologyMore Details
    19224930 "Inflammatory biomarkers, physical activity, waist circumference, and risk of future coronary heart disease in healthy men and women."European heart journalMore Details
    20568015 Effects of myeloperoxidase -463 G/A gene polymorphism and plasma levels on coronary artery disease.Molecular biology reportsMore Details
    20848159 Lack of association between plasma myeloperoxidase levels and angiographic severity of coronary artery disease in patients with acute coronary syndrome.Inflammation research : official journal of the European Histamine ResearchMore Details
    20846733 Diagnostic value of MPO plasma levels in patients admitted for suspected myocardial infarction.International journal of cardiologyMore Details
    21934609 Plasma myeloperoxidase concentration predicts the presence and severity of coronary disease in patients with chest pain and negative troponin-T.Coronary artery diseaseMore Details
    21917261 Race-specific associations of myeloperoxidase with atherosclerosis in a population-based sample: the Dallas Heart Study.AtherosclerosisMore Details
    20851484 Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion.International journal of cardiologyMore Details
    21053005 "Impact of therapy with statins, beta-blockers and angiotensin-converting enzyme inhibitors on plasma myeloperoxidase in patients with coronary artery disease."Clinical research in cardiology : official journal of the German Cardiac SocietyMore Details
    19303649 The effects of G-CSF-induced mobilization of progenitor cells are limited by ADMA.International journal of cardiologyMore Details
    20932115 Role of myeloperoxidase in cardiology.Future cardiologyMore Details
    20305551 Prognostic value of myeloperoxidase in coronary artery disease: comparison of unstable and stable angina patients.Coronary artery diseaseMore Details
    20223364 Myeloperoxidase and C-reactive protein have combined utility for long-term prediction of cardiovascular mortality after coronary angiography.Journal of the American College of CardiologyMore Details
    20201999 Serum myeloperoxidase levels and platelet activation parameters as diagnostic and prognostic markers in the course of coronary disease.International journal of laboratory hematologyMore Details
    20606121 Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study.CirculationMore Details
    20064972 Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export.Journal of lipid researchMore Details
    19651119 Association between myeloperoxidase polymorphisms and its plasma levels with severity of coronary artery disease.Clinical biochemistryMore Details
    19049846 Liberation of vessel adherent myeloperoxidase by enoxaparin improves endothelial function.International journal of cardiologyMore Details
    20394040 Changes in inflammatory biomarkers in patients treated with ticagrelor or clopidogrel.Clinical cardiologyMore Details
    20141341 Inflammatory/oxidative stress during the first week after different types of cardiac surgery.Scandinavian cardiovascular journal : SCJMore Details
    21188207 "Leukocyte counts, myeloperoxidase, and pregnancy-associated plasma protein a as biomarkers for cardiovascular disease: towards a multi-biomarker approach."International journal of vascular medicineMore Details
    19761988 "Myeloperoxidase, subclinical atherosclerosis, and cardiovascular disease events."JACC. Cardiovascular imagingMore Details
    19877084 Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis.Arthritis and rheumatismMore Details
    19322022 A reconstituted HDL containing V156K or R173C apoA-I exhibited anti-inflammatory activity in apo-E deficient mice and showed resistance to myeloperoxidase-mediated oxidation.Experimental & molecular medicineMore Details
    19477372 Inflammatory biomarkers in coronary artery disease.Journal of cardiologyMore Details
    19362143 Neutrophil activation precedes myocardial injury in patients with acute myocardial infarction.Free radical biology & medicineMore Details
    19626395 Serum myeloperoxidase level predicts reperfusion in patients with myocardial infarction receiving thrombolytic therapy.Heart and vesselsMore Details
    18988754 Lack of diagnostic and prognostic utility of circulating plasma myeloperoxidase concentrations in patients presenting with dyspnea.Clinical chemistryMore Details
    19140875 The additive contribution from inflammatory genetic markers on the severity of cardiovascular disease.Scandinavian journal of immunologyMore Details
    19543083 The myeloperoxidase gene and its influence on myocardial infarction in a Swedish population: protective role of the -129A allele in women.Coronary artery diseaseMore Details
    19549340 Monocytes and neutrophils expressing myeloperoxidase occur in fibrous caps and thrombi in unstable coronary plaques.BMC cardiovascular disordersMore Details
    18514165 Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study.Biological psychiatryMore Details
    18601914 Increases in myeloperoxidase levels after exercise in myocardial perfusion scintigraphy are not induced by myocardial ischemia.Clinica chimica acta; international journal of clinical chemistryMore Details
    18823457 Establishment of a porcine right ventricular infarction model for cardioprotective actions of xenon and isoflurane.Acta anaesthesiologica ScandinavicaMore Details
    18339606 Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18.European heart journalMore Details
    18509013 Effect of collection tube type and preanalytical handling on myeloperoxidase concentrations.Clinical chemistryMore Details
    18629312 "Circulating biomarkers of inflammation, antioxidant activity, and platelet activation are associated with primary combustion aerosols in subjects with coronary artery disease."Environmental health perspectivesMore Details
    17892613 Effects of levosimendan on myocardial ischaemia-reperfusion injury.European journal of anaesthesiologyMore Details
    17586510 Low dose apolipoprotein A-I rescues carotid arteries from inflammation in vivo.AtherosclerosisMore Details
    18226042 Myeloperoxidase level in patients with stable coronary artery disease and acute coronary syndromes.European journal of clinical investigationMore Details
    18215608 Prognostic value of plasma myeloperoxidase concentration in patients with stable coronary artery disease.American heart journalMore Details
    18930040 "Low basal levels of circulating adiponectin in patients undergoing coronary stenting predict in-stent restenosis, independently of basal levels of inflammatory markers: lipoprotein associated phospholipase A2, and myeloperoxidase."Clinical biochemistryMore Details
    18440308 Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease.Clinica chimica acta; international journal of clinical chemistryMore Details
    18591459 Increased myeloperoxidase in the placenta and circulation of women with preeclampsia.HypertensionMore Details
    18489792 Can endogenous lipid molecules serve as predictors and prognostic markers of coronary heart disease?Lipids in health and diseaseMore Details
    18382609 Myeloperoxidase: a new biomarker of inflammation in ischemic heart disease and acute coronary syndromes.Mediators of inflammationMore Details
    17880372 Low coronary driving pressure is associated with subendocardial remodelling and left ventricular dysfunction in aortocaval fistula.Clinical and experimental pharmacology & physiologyMore Details
    17512353 Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction.Journal of the American College of CardiologyMore Details
    17493461 Usefulness of baseline plasma myeloperoxidase levels as an independent predictor of myocardial infarction at two years in patients presenting with acute coronary syndrome.The American journal of cardiologyMore Details
    17384009 Multiple biomarker use for detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome.Clinical chemistryMore Details
    17188883 Pretreatment with aminophylline reduces release of Troponin I and neutrophil activation in the myocardium of patients undergoing cardioplegic arrest.European journal of cardio-thoracic surgery : official journal of the EuropeanMore Details
    17616301 Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study.Journal of the American College of CardiologyMore Details
    17275677 Coronary plaque injury triggers neutrophil activation in patients with coronary artery disease.Free radical biology & medicineMore Details
    17050638 Factors involved in vascular calcification and atherosclerosis in maintenance haemodialysis patients."Nephrology, dialysis, transplantation : official publication of the European"More Details
    17473052 Exercise and diet induced weight loss improves measures of oxidative stress and insulin sensitivity in adults with characteristics of the metabolic syndrome.American journal of physiology. Endocrinology and metabolismMore Details
    17525363 Effects of unfractionated heparin and glycoprotein IIb/IIIa antagonists versus bivalirdin on myeloperoxidase release from neutrophils."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16289072 Myeloperoxidase genetic polymorphisms modulate human neutrophil enzyme activity: genetic determinants for atherosclerosis?AtherosclerosisMore Details
    16611638 Metabolism of myeloperoxidase-derived 2-chlorohexadecanal.The Journal of biological chemistryMore Details
    16480969 The effect of atorvastatin on serum myeloperoxidase and CRP levels in patients with acute coronary syndrome.Clinica chimica acta; international journal of clinical chemistryMore Details
    16797387 Serum myeloperoxidase and mortality in maintenance hemodialysis patients.American journal of kidney diseases : the official journal of the National KidneyMore Details
    16639078 "Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males."Journal of lipid researchMore Details
    16723729 Multimarker panel to rule out acute coronary syndromes in low-risk patients.Academic emergency medicine : official journal of the Society for AcademicMore Details
    16171772 Myeloperoxidase-mediated oxidation of high-density lipoproteins: fingerprints of newly recognized potential proatherogenic lipoproteins.Archives of biochemistry and biophysicsMore Details
    16378884 Plasma markers of endothelial dysfunction in type 2 diabetics.European journal of internal medicineMore Details
    16497665 Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I.The Journal of biological chemistryMore Details
    16336978 Mechanism of the cardioprotection of rhEPO pretreatment on suppressing the inflammatory response in ischemia-reperfusion.Life sciencesMore Details
    16606792 Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase.CirculationMore Details
    16761191 Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious hemodynamic effects.Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    16195659 Alcohol-induced lung damage and increased oxidative stress.Respiration; international review of thoracic diseasesMore Details
    15574409 "Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport."The Journal of biological chemistryMore Details
    16411410 Endurance training reduces circulating asymmetric dimethylarginine and myeloperoxidase levels in persons at risk of coronary events.Thrombosis and haemostasisMore Details
    16182131 Formation of dysfunctional high-density lipoprotein by myeloperoxidase.Trends in cardiovascular medicineMore Details
    15304260 Myeloperoxidase enhances nitric oxide catabolism during myocardial ischemia and reperfusion.Free radical biology & medicineMore Details
    15292228 Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species.The Journal of biological chemistryMore Details
    15193837 Automated quantitation of peripheral blood neutrophil activation in patients with myocardial ischaemia.International journal of cardiologyMore Details
    14730210 Myeloperoxidase gene variation and coronary flow reserve in young healthy men.Journal of biomedical scienceMore Details
    15358609 Attenuation of antioxidative capacity enhances reperfusion injury in aged rat myocardium after MI/R.American journal of physiology. Heart and circulatory physiologyMore Details
    15326314 The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport.Proceedings of the National Academy of Sciences of the United States of AmericaMore Details
    12952835 Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes.CirculationMore Details
    14638540 Identification of alpha-chloro fatty aldehydes and unsaturated lysophosphatidylcholine molecular species in human atherosclerotic lesions.CirculationMore Details
    11479475 A functional myeloperoxidase polymorphic variant is associated with coronary artery disease in French-Canadians.American heart journalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 4 unique genes interacted with MPO. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    MPO in vitro10766826,11705390,1320128,7840679,8037771,8718890 CHD related
    CP in vitro9097926 No
    Dynll1 Affinity Capture-MS20360068 No
    RAD21 Affinity Capture-Western22145905 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00244MesalazineFor the treatment of active ulcerative proctitis.A07EC02
    approvedDB00535Cefdinir"For the treatment of the respiratory, skin, soft tissue, and ENT infections caused by <i>H. influenzae</i> (including b-lactamase producing strains), <i>H. parainfluenzae</i> (including b-lactamase producing strains), <i>S. pneumoniae</i> (penicillin-susceptible strains), <i>S. pyogenes</i>, <i>S. aureus</i> (including b-lactamase producing strains), and <i>M. catarrhalis</i>."J01DD15
    approvedDB00583L-Carnitine"For treatment of primary systemic carnitine deficiency, a genetic impairment of normal biosynthesis or utilization of levocarnitine from dietary sources, or for the treatment of secondary carnitine deficiency resulting from an inborn error of metabolism such as glutaric aciduria II, methyl malonic aciduria, propionic acidemia, and medium chain fatty acylCoA dehydrogenase deficiency. Used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias. Parenteral levocarnitine is indicated for the prevention and treatment of carnitine deficiency in patients with end-stage renal disease."A16AA01
    approved;nutraceuticalDB01065Melatonin"Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for this use. A number of studies have shown that melatonin may be effective for treating sleep-wake cycle disturbances in children and adolescents with mental retardation, autism, and other central nervous system disorders. It appears to decrease the time to fall asleep in children with developmental disabilities, such as cerebral palsy, autism, and mental retardation. It may also improve secondary insomnia associated with various sleep-wake cycle disturbances. Other possible uses for which there is some evidence for include: benzodiazepine withdrawal, cluster headache, delayed sleep phase syndrome (DSPS), primary insomnia, jet lag, nicotine withdrawal, preoperative anxiety and sedation, prostate cancer, solid tumors (when combined with IL-2 therapy in certain cancers), sunburn prevention (topical use), tardive dyskinesia, thrombocytopenia associated with cancer, chemotherapy and other disorders. "N05CH01;N05CM17
    withdrawnDB04821NomifensineN06AX04