How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: MTHFR

    Description: "5,10-methylenetetrahydrofolate reductase (NADPH)"

    Entrez Gene ID: 4524

    SwissProt Acc Number: P42898

    RefSeq: NM_005957

    It was suspected to be CHD related:

    ..Both MTHFR genotype and vascular 5-MTHF were associated with vascular nitric oxide bioavailability and superoxide generated by uncoupled endothelial nitric oxide synthase...

    From PMID: 19398669, in Journal Circulation. , 2009


    References

    There were 135 potential papers with MTHFR and CHD.

    PMIDTitleJournalsDetails
    23824729 Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.The American journal of clinical nutritionMore Details
    24197804 Hyperhomocysteinemia is an independent predictor of sub-clinical carotid vascular damage in subjects with grade-1 hypertension.EndocrineMore Details
    24315498 Synergistic association of DNA repair relevant gene polymorphisms with the risk of coronary artery disease in northeastern Han Chinese.Thrombosis researchMore Details
    24218123 The Association of MTHFR C677T Gene Variants and Lipid Profiles or Body Mass Index in Patients With Diabetic and Nondiabetic Coronary Heart Disease.Journal of clinical laboratory analysisMore Details
    22147344 Oxidative Stress is Associated with Genetic Polymorphisms in One-Carbon Metabolism in Coronary Artery Disease.Cell biochemistry and biophysicsMore Details
    23547211 "Cardiovascular events are not associated with MTHFR polymorphisms, but are associated with methotrexate use and traditional risk factors in US veterans with rheumatoid arthritis."The Journal of rheumatologyMore Details
    22647417 The human MTHFR rs4846049 polymorphism increases coronary heart disease risk through modifying miRNA binding."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    23288205 ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing.Genetics in medicine : official journal of the American College of MedicalMore Details
    24014284 The association between plasma homocysteine and coronary heart disease is modified by the MTHFR 677C>T polymorphism.Heart (British Cardiac Society)More Details
    23303523 Loci influencing blood pressure identified using a cardiovascular gene-centric array.Human molecular geneticsMore Details
    23391848 "OLR1, PON1 and MTHFR gene polymorphisms, conventional risk factors and the severity of coronary atherosclerosis in a Chinese Han population."Cellular physiology and biochemistry : international journal of experimentalMore Details
    24310797 Frequency of MTHFR G1793A polymorphism in individuals with early coronary artery disease: cross-sectional study.Sao Paulo medical journal = Revista paulista de medicinaMore Details
    22552896 Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer's disease.Metabolic brain diseaseMore Details
    22339112 Myocardial infarction in a newborn heterozygous for the MTHFR C677T mutation.Pediatric and developmental pathology : the official journal of the Society forMore Details
    22425167 Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk.AtherosclerosisMore Details
    22440940 The rs1801133 polymorphism of methylenetetrahydrofolate reductase gene- the association with 5-year survival in patients with ST-elevation myocardial infarction.Advances in medical sciencesMore Details
    22146089 Methylenetetrahydrofolate reductase C677T gene polymorphism and coronary artery disease in a Chinese Han population: a meta-analysis.Metabolism: clinical and experimentalMore Details
    23032828 Thrombophilic molecular markers in young patients (<40 years) with coronary artery disease.Indian journal of pathology & microbiologyMore Details
    22870016 MTHFR C677T polymorphism is associated with hyperlipidemia in women with polycystic ovary syndrome.Journal of human reproductive sciencesMore Details
    22363213 "Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias."PLoS medicineMore Details
    21803402 Interaction between homocysteine and lipoprotein(a) increases the prevalence of coronary artery disease/myocardial infarction in women: a case-control study.Thrombosis researchMore Details
    21780915 Three genetic polymorphisms of homocysteine-metabolizing enzymes and risk of coronary heart disease: a meta-analysis based on 23 case-control studies.DNA and cell biologyMore Details
    22717531 Individual and summed effects of high-risk genetic polymorphisms on recurrent cardiovascular events following ischemic heart disease.AtherosclerosisMore Details
    23171482 Prothrombotic gene variants as risk factors of acute myocardial infarction in young women.Journal of translational medicineMore Details
    22780915 A novel multiplex polymerase chain reaction assay for profile analyses of gene expression in peripheral blood.BMC cardiovascular disordersMore Details
    21567207 Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease.Molecular and cellular biochemistryMore Details
    21802936 Detection of C677T mutation of MTHFR in subject with coronary heart disease by hairpin probe with enzymatic color on microarray.Biosensors & bioelectronicsMore Details
    21270470 Role of methylenetetrahydrofolate reductase gene (MTHFR) 677C>T polymorphism in pediatric cerebrovascular disorders.Journal of child neurologyMore Details
    22022143 "Genetic interactions between MTHFR (C677T), methionine synthase (A2756G, C2758G) variants with vitamin B12 and folic acid determine susceptibility to premature coronary artery disease in Indian population."Journal of cardiovascular disease researchMore Details
    21380725 Interaction of eNOS polymorphism with MTHFR variants increase the risk of diabetic nephropathy and its progression in type 2 diabetes mellitus patients.Molecular and cellular biochemistryMore Details
    21450592 "Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease."European journal of cardiovascular prevention and rehabilitation : officialMore Details
    21803414 "Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials."LancetMore Details
    22087200 Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population.Korean journal of pediatricsMore Details
    20530057 "Association of the C677T MTHFR polymorphism with homocysteine, ox-LDL levels, and thiolactonase activities in the severity of coronary syndrome."Clinical and applied thrombosis/hemostasis : official journal of theMore Details
    20637366 "C677T polymorphism of the 5,10 MTHFR gene in young Mexican subjects with ST-elevation myocardial infarction."Archives of medical researchMore Details
    20175737 Cystathionine beta-synthase 844Ins68 polymorphism is not associated with the levels of homocysteine and cysteine in an Indian population."Biomarkers : biochemical indicators of exposure, response, and susceptibility to "More Details
    19913857 Low folate levels may be an atherogenic factor regardless of homocysteine levels in young healthy nonsmokers.Metabolism: clinical and experimentalMore Details
    21187870 Polymorphisms of methylenetetrahydrofolate reductase gene as the genetic predispositions of coronary artery diseases in eastern India.Journal of cardiovascular disease researchMore Details
    19283448 Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease.Journal of thrombosis and thrombolysisMore Details
    20421795 Nutrigenetic impact of daily folate intake on plasma homocysteine and folate levels in patients with different methylenetetrahydrofolate reductase genotypes.European journal of cardiovascular prevention and rehabilitation : officialMore Details
    21637473 Association of homocysteine and methylene tetrahydrofolate reductase (MTHFR C677T) gene polymorphism with coronary artery disease (CAD) in the population of North India.Genetics and molecular biologyMore Details
    19577940 Polygenic association with total homocysteine in the post-folic acid fortification era: the CARDIA study.Molecular genetics and metabolismMore Details
    19466593 Prevalence of methylenetetrahydrofolate gene (MTHFR) C677T polymorphism among chronic hemodialysis patients and its association with cardiovascular disease: a cross-sectional analysis.Clinical and experimental nephrologyMore Details
    19123042 Impact of hemostatic gene single point mutations in patients with non-diabetic coronary artery disease.Molecular biology reportsMore Details
    19398669 "MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis."CirculationMore Details
    19219535 "Association of genetic variants in Methylenetetrahydrofolate Reductase and Paraoxonase-1 genes with homocysteine, folate and vitamin B12 in coronary artery disease."Molecular and cellular biochemistryMore Details
    19349859 "Factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase polymorphism C677T are not associated with coronary artery disease and type 2 diabetes mellitus in western Iran."Blood coagulation & fibrinolysis : an international journal in haemostasis andMore Details
    19394322 Genetic and environmental influences on total plasma homocysteine and coronary artery disease (CAD) risk among South Indians.Clinica chimica acta; international journal of clinical chemistryMore Details
    19056652 Clinical utility of genotyping the 677C>T variant of methylenetetrahydrofolate reductase in humans is decreased in the post-folic acid fortification era.The Journal of nutritionMore Details
    18204887 Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Tunisian patients with severe coronary artery disease.Journal of thrombosis and thrombolysisMore Details
    19525478 Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study.BloodMore Details
    19303062 "Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations."American journal of human geneticsMore Details
    18255072 Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of premature myocardial infarction.AtherosclerosisMore Details
    18037339 Genetic polymorphisms and micronucleus formation: a review of the literature.Mutation researchMore Details
    18373406 High prevalence of MTHFR gene A1298C polymorphism in Lebanon.Genetic testingMore Details
    18074111 "Association of polymorphism in the thermolabile 5, 10-methylene tetrahydrofolate reductase gene and hyperhomocysteinemia with coronary artery disease."Molecular and cellular biochemistryMore Details
    18457979 Severe atherosclerosis in rheumatoid arthritis and hyperhomocysteinemia: is there a link?"Joint, bone, spine : revue du rhumatisme"More Details
    17027242 Circulating homocysteine levels in patients with type 2 diabetes mellitus."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    18068006 "The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels."Archives of medical researchMore Details
    17917766 Methylenetetrahydrofolate reductase TT genotype as a predictor of cardiovascular risk in hypertensive adolescents.Pediatric cardiologyMore Details
    18704761 Molecular genetics of myocardial infarction.Genomic medicineMore Details
    17683517 The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics.Annals of human geneticsMore Details
    18053808 Distinct association of SLC19A1 polymorphism -43T>C with red cell folate levels and of MTHFR polymorphism 677C>T with plasma folate levels.Clinical biochemistryMore Details
    17999084 Relationship between two sequence variations in the gene for peroxisome proliferator-activated receptor-gamma and plasma homocysteine concentration. Health in men study.Human geneticsMore Details
    18622257 "Interactions between the single nucleotide polymorphisms in the homocysteine pathway (MTHFR 677C>T, MTHFR 1298 A>C, and CBSins) and the efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular disease in high-risk patients of hypertension: the GenHAT study."Pharmacogenetics and genomicsMore Details
    18620331 "[Effect of polymorphisms on key enzymes in homocysteine metabolism, on plasma homocysteine level and on coronary artery-disease risk in a Tunisian population]."Annales de cardiologie et d'angeiologieMore Details
    18384842 "Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: the A1298C polymorphism does matter. Inferences from a case study (Madeira, Portugal)."Thrombosis researchMore Details
    17403027 The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk.Annals of human geneticsMore Details
    17822659 "Relation between plasma homocysteine, gene polymorphisms of homocysteine metabolism-related enzymes, and angiographically proven coronary artery disease."European journal of internal medicineMore Details
    17354258 The relationship of the methylenetetrahydrofolate reductase C677T gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy.Diabetes/metabolism research and reviewsMore Details
    17052775 Effect of folic acid treatment on carotid intima-media thickness of patients with coronary disease.International journal of cardiologyMore Details
    17591934 Improved real-time multiplex polymerase chain reaction detection of methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C polymorphisms using nearest neighbor model-based probe design.The Journal of molecular diagnostics : JMDMore Details
    17553479 A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case-control study.Clinical biochemistryMore Details
    16472842 Sequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population.Thrombosis researchMore Details
    17005242 Hyperhomocysteinemia is a risk factor of recurrent coronary event in young patients irrespective to the MTHFR C677T polymorphism.Thrombosis researchMore Details
    17497026 Thermolabile methylenetetrahydrofolate reductase C677T polymorphism and homocysteine are risk factors for coronary artery disease in Moroccan population.Journal of biomedicine & biotechnologyMore Details
    17604826 Dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization.Thrombosis researchMore Details
    16953277 Folic acid administration and antibodies against homocysteinylated proteins in subjects with hyperhomocysteinemia.Thrombosis and haemostasisMore Details
    16968465 "Homocysteine, traditional risk factors and impaired renal function in coronary artery disease."European journal of clinical investigationMore Details
    16928730 Identifying genetic susceptibilities to diabetes-related complications among individuals at low risk of complications: An application of tree-structured survival analysis.American journal of epidemiologyMore Details
    16704755 "Hyperhomocysteinaemia, methylenetetrahydrofolate reductase polymorphism and risk of coronary artery disease."Annals of clinical biochemistryMore Details
    16681562 The MTHFR CT polymorphism confers a high risk for stroke in both homozygous and heterozygous T allele carriers with Type 2 diabetes.Diabetic medicine : a journal of the British Diabetic AssociationMore Details
    16439690 Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease.Circulation researchMore Details
    16489563 677TT polymorphism of methylenetetrahydrofolate reductase in combination with low serum vitamin B12 is associated with coronary in-stent restenosis.Catheterization and cardiovascular interventions : official journal of theMore Details
    16487909 Interaction between Mediterranean diet and methylenetetrahydrofolate reductase C677T mutation on oxidized low density lipoprotein concentrations: the ATTICA study."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    16574759 Frequency of thrombophilia-related genetic variations in patients with idiopathic pulmonary embolism in an urban emergency department.Clinical chemistryMore Details
    15648053 C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease.Cell biochemistry and functionMore Details
    16380544 Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism.CirculationMore Details
    16397167 Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients.Stroke; a journal of cerebral circulationMore Details
    16401615 "Plasma total homocysteine levels in children with type 1 diabetes: relationship with vitamin status, methylene tetrahydrofolate reductase genotype, disease parameters and coronary risk factors."Journal of tropical pediatricsMore Details
    16612468 Hyperhomocystinemia in patients with coronary artery disease.Brazilian journal of medical and biological research = Revista brasileira deMore Details
    17183715 Hyperhomocysteinemia and mortality after coronary artery bypass grafting.PloS oneMore Details
    15935452 Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population.Thrombosis researchMore Details
    16268464 "Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population."Thrombosis and haemostasisMore Details
    16207540 Lack of evidence of association between MTHFR C677T polymorphism and congenital heart disease in a TDT study design.International journal of cardiologyMore Details
    16194201 Modeling premature occurrence of acute coronary syndrome with atherogenic and thrombogenic risk factors and gene markers in extended families.Journal of thrombosis and haemostasis : JTHMore Details
    16216822 Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?BMJ (Clinical research ed.)More Details
    16259797 The influence of genetic and environmental factors on plasma homocysteine concentrations in a population at high risk for coronary artery disease.Annals of clinical biochemistryMore Details
    15950563 "Family history, plasma homocysteine, and age at onset of symptoms of myocardial ischemia in patients with different methylenetetrahydrofolate reductase genotypes."The American journal of cardiologyMore Details
    15607533 Methylenetetrahydrofolate reductase polymorphism associated with susceptibility to coronary heart disease in Chinese type 2 diabetic patients.Molecular and cellular endocrinologyMore Details
    15829163 Methylenetetrahydrofolate reductase gene polymorphisms in patients with cerebral hemorrhage.Neurological researchMore Details
    15612980 Genetic polymorphisms predisposing to hyperhomocysteinemia in cardiac transplant patients.Transplant international : official journal of the European Society for OrganMore Details
    15595935 Endothelial nitric oxide synthase gene interactions and the risk of ischaemic stroke.Acta neurologica ScandinavicaMore Details
    15711753 Antibodies to N-homocysteinylated albumin as a marker for early-onset coronary artery disease in men.Thrombosis and haemostasisMore Details
    16379339 "Influence of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, B vitamins and other factors on plasma homocysteine and risk of thromboembolic disease in Chinese."Journal of the Chinese Medical Association : JCMAMore Details
    16248996 Prevalence of genetic risk factors for coronary artery disease in Corsica island (France).Experimental and molecular pathologyMore Details
    15996600 The methylenetetrahydrofolate reductase C677T polymorphism does not associate with susceptibility to abdominal aortic aneurysm.European journal of vascular and endovascular surgery : the official journal ofMore Details
    15777550 "Serum homocysteine, methylenetetrahydrofolate reductase gene polymorphism and cardiovascular disease in heterozygous familial hypercholesterolemia."AtherosclerosisMore Details
    16274479 Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes.Cardiovascular diabetologyMore Details
    15321841 An integrated approach to the meta-analysis of genetic association studies using Mendelian randomization.American journal of epidemiologyMore Details
    15301885 C677T polymorphism of the methylenetetrahydrofolate reductase gene is a risk factor of adverse events after coronary revascularization.International journal of cardiologyMore Details
    15458711 The methylenetetrahydrofolate reductase gene polymorphism (C677T) is associated with increased cardiovascular mortality in Hungary.International journal of cardiologyMore Details
    15135689 "Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery disease."The American journal of cardiologyMore Details
    14769778 Pharmacokinetic study on the utilisation of 5-methyltetrahydrofolate and folic acid in patients with coronary artery disease.British journal of pharmacologyMore Details
    15353918 "Factor V G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T gene polymorphism in angiographically documented coronary artery disease."Journal of thrombosis and thrombolysisMore Details
    15193960 Ethnic differences of coronary artery disease-associated SNPs in two Israeli healthy populations using MALDI-TOF mass spectrometry.Life sciencesMore Details
    12899665 Candidate genetic markers and the risk of restenosis after coronary angioplasty."Clinical science (London, England : 1979)"More Details
    15019536 "Serum homocysteine concentrations, gemfibrozil treatment, and progression of coronary atherosclerosis."AtherosclerosisMore Details
    12939653 Genetic polymorphisms in folate and homocysteine metabolism as risk factors for DNA damage.European journal of human genetics : EJHGMore Details
    14521457 Prevalence and role of methylenetetrahydrofolate reductase 677 C-->T and 1298 A-->C polymorphisms in coronary artery disease in Arabs.Archives of pathology & laboratory medicineMore Details
    12522558 "Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease."Human geneticsMore Details
    14642003 High incidence of two methylenetetrahydrofolate reductase mutations (C677T and A1298C) in Hispanics.Genetic testingMore Details
    14604831 Homocysteine status and polymorphisms of methylenetetrahydrofolate reductase are not associated with restenosis after stenting in coronary arteries."Arteriosclerosis, thrombosis, and vascular biology"More Details
    12833177 "Carrier-state of D allele in ACE gene insertion/deletion polymorphism is associated with coronary artery disease, in contrast to the C677-->T transition in the MTHFR gene."Acta biochimica PolonicaMore Details
    12049616 "Homocysteine, folate, methylene tetrahydrofolate reductase genotype and vascular morbidity in diabetic subjects.""Clinical science (London, England : 1979)"More Details
    23105344 "Polymorphism (C677T) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene: A preliminary study on north Indian men."Indian journal of clinical biochemistry : IJCBMore Details
    12189485 Major gene evidence after MTHFR-segregation analysis of serum homocysteine in families of patients undergoing coronary arteriography.Human geneticsMore Details
    12124994 Highly multiplexed genotyping of coronary artery disease-associated SNPs using MALDI-TOF mass spectrometry.Human mutationMore Details
    11929966 "A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status."Proceedings of the National Academy of Sciences of the United States of AmericaMore Details
    11956665 The effects of folate supplementation on some coagulation parameters and oxidative status surrogates.European journal of clinical pharmacologyMore Details
    11386855 "Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease, and essential hypertension in the Czech population."Molecular genetics and metabolismMore Details
    11161947 Methylenetetrahydrofolate reductase genotypes and predisposition to atherothrombotic disease; evidence that all three MTHFR C677T genotypes confer different levels of risk.European heart journalMore Details
    11292330 Genetic variation of the methylenetetrahydrofolate reductase and cystathionine beta-synthase genes in Korean patients with coronary artery disease and a new polymorphism in intron 7.Molecular and cellular probesMore Details
    11096270 The C677T mutation of the methylenetetrahydrofolate reductase gene is not associated with the risk of coronary artery disease or venous thrombosis among Chinese in Taiwan.Human heredityMore Details
    11092508 Methylenetetrahydrofolate reductase mutation (677C-->T) negatively influences plasma homocysteine response to marginal folate intake in elderly women.Metabolism: clinical and experimentalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 1 unique genes interacted with MTHFR. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    NAA38 Two-hybrid15231747 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approved;nutraceuticalDB00115CyanocobalaminFor treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency.B03BB01;B03BA01
    approved;nutraceuticalDB00116Tetrahydrofolic acid"For nutritional supplementation, also for treating dietary shortage or imbalance."
    approved;nutraceuticalDB00116Tetrahydrofolic acid"For nutritional supplementation, also for treating dietary shortage or imbalance."
    approved;nutraceuticalDB00116Tetrahydrofolic acid"For nutritional supplementation, also for treating dietary shortage or imbalance."