How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: MTTP

    Description: microsomal triglyceride transfer protein

    Entrez Gene ID: 4547

    SwissProt Acc Number: P55157

    RefSeq: NM_000253

    It was suspected to be CHD related:

    ..The microsomal triglyceride transfer protein (MTTP) is essential for the assembly of VLDLs. ..

    From PMID: 16617174, in Journal J Lipid Res , 2006


    References

    There were 4 potential papers with MTTP and CHD.

    PMIDTitleJournalsDetails
    20412465 Lignophenols decrease oleate-induced apolipoprotein-B secretion in HepG2 cells.Basic & clinical pharmacology & toxicologyMore Details
    20112301 Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats.Molecular nutrition & food researchMore Details
    19255880 Linkage disequilibrium between four MTTP gene polymorphisms in a Mexican population.Annals of human biologyMore Details
    16617174 The Ile128Thr polymorphism influences stability and ligand binding properties of the microsomal triglyceride transfer protein.Journal of lipid researchMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 2 unique genes interacted with MTTP. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    APOB Two-hybrid9915855 CHD related
    HSP90B1 in vivo9694898 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB01094Hesperetin"For lowering cholesterol and, possibly, otherwise favorably affecting lipids. <i>In vitro</i> research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again."