How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: MYC

    Description: v-myc myelocytomatosis viral oncogene homolog (avian)

    Entrez Gene ID: 4609

    SwissProt Acc Number: P01106

    RefSeq: NM_002467

    It was suspected to be CHD related:

    .."We showed that TLR2, CXCR4 and MYC are overexpressed in monocytes of obese women at high cardiovascular risk and that weight loss was associated with a concomitant decrease of their expression."..

    From PMID: 18669160, in Journal Verh K Acad Geneeskd Belg.? , 2008


    References

    There were 2 potential papers with MYC and CHD.

    PMIDTitleJournalsDetails
    15364876 Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest.CirculationMore Details
    14498825 The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growth.Expert opinion on therapeutic targetsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 471 unique genes interacted with MYC. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    SNRNP200 Affinity Capture-MS17353931|17314511|22623531 No
    HEATR1 Affinity Capture-MS17353931 No
    METTL13 Affinity Capture-MS17353931 No
    NUP205 Affinity Capture-MS17353931 No
    MSH6 Affinity Capture-MS17353931|17314511 No
    MCM7 Affinity Capture-MS17353931|17314511|17314511|17314511 No
    POLE Affinity Capture-MS17353931|17314511 No
    NUP93 Affinity Capture-MS17353931 No
    FANCI Affinity Capture-MS17353931 No
    GCN1L1 Affinity Capture-MS17353931|20936779|17314511 No
    DDX24 Affinity Capture-MS17353931 No
    ARHGEF2 Affinity Capture-MS17353931|17314511 No
    GEMIN4 Affinity Capture-MS17353931 No
    PRPF8 Affinity Capture-MS17353931 No
    MYBBP1A Affinity Capture-MS17353931|17314511 No
    EXOC4 Affinity Capture-MS17353931 No
    GTF3C3 Affinity Capture-MS17353931|17314511 No
    MAX Affinity Capture-MS17353931|10319872|12584560|2006410|10593926|19578763|16705173|16287840|12821782|15572685|18003922|17471507|17418410|17700062|17643117|20382893|20946988|20946988|17314511|17314511|16352593|9680483|2006410,17072308,10229200,9680483,17418410,17157259 No
    MKLN1 Affinity Capture-MS17353931 No
    EFTUD2 Affinity Capture-MS17353931|17314511 No
    SMARCA4 Affinity Capture-MS17353931|11839798|14559996 No
    MYO1B Affinity Capture-MS17353931 No
    HNRNPC Affinity Capture-MS17353931 No
    PDS5A Affinity Capture-MS17353931 No
    KIAA1967 Affinity Capture-MS17353931|17314511|17314511|17314511 No
    NMI Affinity Capture-Western11916966|11916966 No
    MAPK3 Reconstituted Complex15210690 CHD related
    MAPK1 Reconstituted Complex15210690|7957875 CHD related
    CCNT1 Affinity Capture-Western12944920|19818711|11673469|17700062 No
    CDK9 Affinity Capture-Western12944920|19818711|11673469|17700062 No
    CEBPA Affinity Capture-Western12873812|12873812 No
    CEBPB Affinity Capture-Western12873812|12873812 No
    TRRAP Affinity Capture-Western12660246|12660246|10611234|9708738|11839798|19818711|16705173|20946988|20946988|17314511|22623531 No
    KAT2B Affinity Capture-Western12660246|12660246|12660246 No
    SUPT3H Affinity Capture-Western12660246|12660246|12660246|17967894 No
    TAF9 Affinity Capture-Western12660246|12660246|12660246 No
    TADA2A Reconstituted Complex12660246|12660246 No
    TAF5 Reconstituted Complex12660246 No
    MED12 Reconstituted Complex12660246 No
    MED14 Reconstituted Complex12660246 No
    POLR2A Reconstituted Complex12660246|17314511 No
    GTF2B Reconstituted Complex12660246 No
    SAP130 Reconstituted Complex12660246|12660246 No
    TAF5L Co-purification12660246 No
    TAF6L Co-purification12660246 No
    TADA3 Co-purification12660246 No
    TAF10 Co-purification12660246 No
    TAF12 Co-purification12660246 No
    KAT2A Affinity Capture-Western10611234|17967894|20691906 No
    EP400 Reconstituted Complex11509179|11509179|20946988|20946988 No
    RUVBL1 Reconstituted Complex11509179|11839798|11839798|17314511 No
    RUVBL2 Co-purification11839798|20509972|17314511 No
    ACTB Co-purification11839798 No
    ACTL6A Co-purification11839798|11839798|17314511 No
    MLH1 Two-hybrid12584560|12584560|12584560 No
    MSH2 Affinity Capture-Western12584560|17314511 No
    RAF1 Reconstituted Complex9315742|17314511|9315742 CHD related
    TIAM1 Affinity Capture-Western12446731|12446731 No
    TFAP2A Affinity Capture-Western7729426 No
    CD6 Affinity Capture-Western10899308 No
    TBP Reconstituted Complex8755740|15723054 No
    GTF2F1 Reconstituted Complex8755740|8755740 No
    Eif4e Phenotypic Suppression15098029 No
    SMAD2 Affinity Capture-Western11804592|11804592|11804592 CHD related
    SMAD3 Affinity Capture-Western11804592|11804592|11804592 CHD related
    RELA Affinity Capture-Western12027803|15616592|12027803 CHD related
    MYCBP Two-hybrid9797456 No
    RBL1 Affinity Capture-Western8076603|8076603 No
    SF3B1 Two-hybrid20936779 No
    MEN1 Affinity Capture-Western19818711|19818711 No
    SMARCA2 Reconstituted Complex14559996 No
    SMARCC1 Reconstituted Complex14559996|17314511 No
    EP300 Affinity Capture-Western16287840|16287840|16287840|15616592|17157259|12776737,17157259 CHD related
    CREB1 Affinity Capture-Western12776737|12776737 No
    HDAC3 Affinity Capture-Western18483244|22002311 CHD related
    GSK3A Affinity Capture-Western14563837|14563837 No
    GSK3B Affinity Capture-Western14563837|19131971|11877389,8247524,16247449 CHD related
    CDCA7L Two-hybrid15994933|15994933|15994933 No
    CUL1 Affinity Capture-Western12769844 No
    CARM1 Affinity Capture-Western15616592 No
    CDK8 Reconstituted Complex11673469 No
    CCNH Reconstituted Complex11673469 No
    FOXO3 Affinity Capture-Western18393360 CHD related
    BIN1 Reconstituted Complex10380878|15992821|15992821 No
    HIF1A Affinity Capture-Western15071503 CHD related
    MED1 Reconstituted Complex17967894 No
    MED16 Reconstituted Complex17967894 No
    UBE2L3 Affinity Capture-Western11431533 No
    NFE2L2 Affinity Capture-Western20232342 CHD related
    BTRC Affinity Capture-Western20852628 No
    BRD8 Affinity Capture-MS20946988 No
    EPC1 Affinity Capture-MS20946988 No
    EPC2 Affinity Capture-MS20946988 No
    HBP1 Two-hybrid20008325|20008325 No
    ZNF281 Affinity Capture-MS17314511|17314511|17314511 No
    TRIM28 Affinity Capture-MS17314511 No
    POLR2B Affinity Capture-MS17314511 No
    ABI3BP Affinity Capture-MS17314511 No
    CHD4 Affinity Capture-MS17314511 No
    HDAC2 Affinity Capture-MS17314511 CHD related
    HIST1H2BL Affinity Capture-MS17314511 No
    SMARCA5 Affinity Capture-MS17314511 No
    HELLS Affinity Capture-MS17314511 No
    TOP1 Affinity Capture-MS17314511 No
    TOP2A Affinity Capture-MS17314511 No
    NONO Affinity Capture-MS17314511 No
    MMS19 Affinity Capture-MS17314511 No
    GTF3C1 Affinity Capture-MS17314511 No
    GTF3C4 Affinity Capture-MS17314511 No
    GTF3C2 Affinity Capture-MS17314511 No
    FBL Affinity Capture-MS17314511 No
    HNRNPF Affinity Capture-MS17314511 No
    HNRNPK Affinity Capture-MS17314511 No
    LRPPRC Affinity Capture-MS17314511 No
    NOP56 Affinity Capture-MS17314511 No
    DIMT1 Affinity Capture-MS17314511 No
    DDX1 Affinity Capture-MS17314511 No
    DHX15 Affinity Capture-MS17314511 No
    DDX20 Affinity Capture-MS17314511 No
    DDX52 Affinity Capture-MS17314511 No
    HNRNPA0 Affinity Capture-MS17314511 No
    IGF2BP1 Affinity Capture-MS17314511 No
    IGF2BP2 Affinity Capture-MS17314511 No
    U2SURP Affinity Capture-MS17314511 No
    RNGTT Affinity Capture-MS17314511 No
    RNH1 Affinity Capture-MS17314511 No
    RPP30 Affinity Capture-MS17314511 No
    PRPF6 Affinity Capture-MS17314511 No
    XRN1 Affinity Capture-MS17314511 No
    AKAP8L Affinity Capture-MS17314511 No
    POLD1 Affinity Capture-MS17314511 No
    CHTF18 Affinity Capture-MS17314511 No
    RFC2 Affinity Capture-MS17314511 No
    RFC3 Affinity Capture-MS17314511 No
    RFC5 Affinity Capture-MS17314511 No
    SMC2 Affinity Capture-MS17314511 No
    SMC4 Affinity Capture-MS17314511 No
    PRKDC Affinity Capture-MS17314511 No
    XRCC6 Affinity Capture-MS17314511|17314511 No
    FANCD2 Affinity Capture-MS17314511 No
    ERCC3 Affinity Capture-MS17314511 No
    XRCC5 Affinity Capture-MS17314511 No
    MSH3 Affinity Capture-MS17314511 No
    EIF3I Affinity Capture-MS17314511 No
    EEF1G Affinity Capture-MS17314511 No
    EIF4A1 Affinity Capture-MS17314511 No
    EIF4ENIF1 Affinity Capture-MS17314511 No
    MARS Affinity Capture-MS17314511 No
    MRPS22 Affinity Capture-MS17314511 No
    MRPS34 Affinity Capture-MS17314511 No
    NCL Affinity Capture-MS17314511 No
    PCBP1 Affinity Capture-MS17314511 No
    PELO Affinity Capture-MS17314511 No
    SARS Affinity Capture-MS17314511 No
    PSMC4 Affinity Capture-MS17314511 No
    SKP1 Affinity Capture-MS17314511 No
    PSMD3 Affinity Capture-MS17314511 No
    PSMA1 Affinity Capture-MS17314511 No
    PSMA2 Affinity Capture-MS17314511 No
    PSMA5 Affinity Capture-MS17314511 No
    PSMB1 Affinity Capture-MS17314511 No
    PSMB3 Affinity Capture-MS17314511 No
    PSMD2 Affinity Capture-MS17314511 No
    PSME4 Affinity Capture-MS17314511 No
    UBE3C Affinity Capture-MS17314511 No
    UBR2 Affinity Capture-MS17314511 No
    FBXW8 Affinity Capture-MS17314511|17314511|17314511 No
    LONP1 Affinity Capture-MS17314511 No
    PSMA3 Affinity Capture-MS17314511 No
    PSMA4 Affinity Capture-MS17314511 No
    PSMA7 Affinity Capture-MS17314511 No
    PSMB4 Affinity Capture-MS17314511 No
    PSMB5 Affinity Capture-MS17314511 No
    PSMC2 Affinity Capture-MS17314511|22623531 No
    PSMC3 Affinity Capture-MS17314511 No
    PSMC6 Affinity Capture-MS17314511 No
    SQSTM1 Affinity Capture-MS17314511 No
    BCR Affinity Capture-MS17314511 CHD related
    PPP6C Affinity Capture-MS17314511 No
    ARL1 Affinity Capture-MS17314511 No
    DPM1 Affinity Capture-MS17314511 No
    MOGS Affinity Capture-MS17314511 No
    GSG2 Affinity Capture-MS17314511|22623531 No
    IRAK1 Affinity Capture-MS17314511 CHD related
    WDR77 Affinity Capture-MS17314511 No
    NEK9 Affinity Capture-MS17314511 No
    PLK1 Affinity Capture-MS17314511 No
    PPP1CA Affinity Capture-MS17314511 No
    PTPN14 Affinity Capture-MS17314511 No
    RPN1 Affinity Capture-MS17314511 No
    RPN2 Affinity Capture-MS17314511 No
    DNAJA2 Affinity Capture-MS17314511 No
    DNAJB6 Affinity Capture-MS17314511 No
    HSPB1 Affinity Capture-MS17314511 No
    HSPD1 Affinity Capture-MS17314511 CHD related
    TCP1 Affinity Capture-MS17314511 No
    CCT2 Affinity Capture-MS17314511 No
    CCT3 Affinity Capture-MS17314511 No
    CCT5 Affinity Capture-MS17314511 No
    DNAJA3 Affinity Capture-MS17314511 No
    CCT4 Affinity Capture-MS17314511 No
    CCT6A Affinity Capture-MS17314511 No
    CCT8 Affinity Capture-MS17314511 No
    HSPH1 Affinity Capture-MS17314511 No
    AKAP8 Affinity Capture-MS17314511 No
    IRS4 Affinity Capture-MS17314511 No
    C1QBP Affinity Capture-MS17314511 No
    IKBKAP Affinity Capture-MS17314511 No
    CYR61 Affinity Capture-MS17314511 CHD related
    MAPKAP1 Affinity Capture-MS17314511 No
    SHOC2 Affinity Capture-MS17314511 No
    YWHAB Affinity Capture-MS17314511 No
    YWHAE Affinity Capture-MS17314511 No
    YWHAQ Affinity Capture-MS17314511 No
    TUBA4A Affinity Capture-MS17314511 No
    COPG Affinity Capture-MS17314511 No
    COPG2 Affinity Capture-MS17314511 No
    CSE1L Affinity Capture-MS17314511 No
    IPO4 Affinity Capture-MS17314511 No
    IPO7 Affinity Capture-MS17314511 No
    IQGAP2 Affinity Capture-MS17314511 No
    KPNB1 Affinity Capture-MS17314511 No
    MYO9B Affinity Capture-MS17314511 No
    NUP133 Affinity Capture-MS17314511 No
    SLC25A12 Affinity Capture-MS17314511 No
    SLC25A13 Affinity Capture-MS17314511 No
    XPO1 Affinity Capture-MS17314511 No
    ARF4 Affinity Capture-MS17314511 No
    DYNC1H1 Affinity Capture-MS17314511 No
    IPO13 Affinity Capture-MS17314511 No
    IPO9 Affinity Capture-MS17314511 No
    KPNA2 Affinity Capture-MS17314511 No
    KPNA4 Affinity Capture-MS17314511 No
    LMNA Affinity Capture-MS17314511 CHD related
    MYO5C Affinity Capture-MS17314511 No
    MYO9A Affinity Capture-MS17314511 No
    NUP153 Affinity Capture-MS17314511 No
    EIF3E Affinity Capture-MS17314511 CHD related
    RANBP2 Affinity Capture-MS17314511 No
    SLC25A1 Affinity Capture-MS17314511 No
    SLC25A11 Affinity Capture-MS17314511 No
    TUBG1 Affinity Capture-MS17314511 No
    TUBGCP2 Affinity Capture-MS17314511 No
    XPO5 Affinity Capture-MS17314511 No
    XPOT Affinity Capture-MS17314511 No
    ALDH1B1 Affinity Capture-MS17314511 No
    HADHB Affinity Capture-MS17314511 No
    IDH3B Affinity Capture-MS17314511 No
    NDUFS3 Affinity Capture-MS17314511 No
    OAT Affinity Capture-MS17314511 No
    P4HA1 Affinity Capture-MS17314511 No
    AASS Affinity Capture-MS17314511 No
    ALDH18A1 Affinity Capture-MS17314511 No
    ASS1 Affinity Capture-MS17314511 No
    ATP5C1 Affinity Capture-MS17314511 No
    ATP5J2 Affinity Capture-MS17314511 No
    CEPT1 Affinity Capture-MS17314511 No
    ETFA Affinity Capture-MS17314511 No
    GANAB Affinity Capture-MS17314511 No
    GCDH Affinity Capture-MS17314511 No
    IDH3A Affinity Capture-MS17314511 No
    IDH3G Affinity Capture-MS17314511 No
    NDUFA5 Affinity Capture-MS17314511 No
    NDUFA8 Affinity Capture-MS17314511 No
    NDUFS1 Affinity Capture-MS17314511 No
    NDUFS2 Affinity Capture-MS17314511 No
    PLOD3 Affinity Capture-MS17314511 No
    PPT1 Affinity Capture-MS17314511 No
    ACOT8 Affinity Capture-MS17314511 No
    PTGES2 Affinity Capture-MS17314511 No
    SPTLC1 Affinity Capture-MS17314511 No
    IQGAP3 Affinity Capture-MS17314511 No
    TMPO Affinity Capture-MS17314511 No
    TRMT1L Affinity Capture-MS17314511 No
    TTC27 Affinity Capture-MS17314511 No
    HIGD1A Affinity Capture-MS17314511 No
    ILVBL Affinity Capture-MS17314511 No
    SLIT2 Affinity Capture-MS17314511 No
    SQRDL Affinity Capture-MS17314511 No
    SSR4 Affinity Capture-MS17314511 No
    SUCLG1 Affinity Capture-MS17314511 No
    ZNF121 Affinity Capture-MS17314511 No
    PPP2R5A Affinity Capture-Western19131971 No
    PIN1 Affinity Capture-Western19131971|15048125 No
    PPP2CA Affinity Capture-Western19131971 CHD related
    DDB1 Affinity Capture-Western20551172 No
    CUL4A Affinity Capture-Western20551172 No
    TRPC4AP Affinity Capture-Western20551172 No
    CDR2 Affinity Capture-Western20383333 No
    GALR3 Affinity Capture-MS20848231 No
    LRRC59 Affinity Capture-MS20848231 No
    FBXO8 Affinity Capture-MS20848231|20848231 No
    GCHFR Affinity Capture-MS20848231 No
    SLC25A3 Affinity Capture-MS20848231 No
    MYC Affinity Capture-MS20848231 CHD related
    STUB1 Reconstituted Complex22543587|22543587 No
    ADRBK2 Dosage Lethality22623531 No
    ALDOA Dosage Lethality22623531 No
    ALPK1 Dosage Lethality22623531 No
    AIFM2 Dosage Lethality22623531 No
    NECAB3 Dosage Lethality22623531 No
    SPEG Dosage Lethality22623531 No
    ARFGEF2 Dosage Lethality22623531 No
    ATP5D Dosage Lethality22623531 No
    BMPR1A Dosage Lethality22623531 No
    BNIP2 Dosage Lethality22623531 No
    BOK Dosage Lethality22623531 No
    BRD4 Dosage Lethality22623531 No
    BTK Dosage Lethality22623531 No
    C17orf49 Dosage Lethality22623531 No
    FAM131C Dosage Lethality22623531 No
    CAMK1G Dosage Lethality22623531 No
    CAMK2D Dosage Lethality22623531 CHD related
    CAMK2G Dosage Lethality22623531 CHD related
    CCNK Dosage Lethality22623531 No
    CDH5 Dosage Lethality22623531 CHD related
    CDK2 Dosage Lethality22623531 No
    CECR2 Dosage Lethality22623531 No
    CPS1 Dosage Lethality22623531 No
    CRADD Dosage Lethality22623531 No
    CDK12 Dosage Lethality22623531 No
    CSNK1E Dosage Lethality22623531 No
    CTPS Dosage Lethality22623531 No
    CTSD Dosage Lethality22623531 No
    CXXC1 Dosage Lethality22623531 No
    DDB2 Dosage Lethality22623531 No
    EFNA5 Dosage Lethality22623531 No
    FBXO5 Dosage Lethality22623531 No
    GLI1 Dosage Lethality22623531 No
    GNRHR Dosage Lethality22623531 No
    GRK1 Dosage Lethality22623531 No
    GTF2H4 Dosage Lethality22623531 No
    HCK Dosage Lethality22623531 No
    HECTD3 Dosage Lethality22623531 No
    HPS1 Dosage Lethality22623531 No
    HSD17B4 Dosage Lethality22623531 No
    ICT1 Dosage Lethality22623531 No
    IGF2R Dosage Lethality22623531 No
    IRS2 Dosage Lethality22623531 CHD related
    ITGB5 Dosage Lethality22623531 No
    KIF18A Dosage Lethality22623531 No
    LATS1 Dosage Lethality22623531 No
    LIMK2 Dosage Lethality22623531 No
    MAP2K3 Dosage Lethality22623531 No
    MAP2K7 Dosage Lethality22623531 No
    MAP3K13 Dosage Lethality22623531 No
    MATK Dosage Lethality22623531 No
    MCL1 Dosage Lethality22623531 No
    CENPO Dosage Lethality22623531 No
    MYLK3 Dosage Lethality22623531 No
    MYLK Dosage Lethality22623531 CHD related
    MYO3B Dosage Lethality22623531 No
    NEIL1 Dosage Lethality22623531 No
    NEK2 Dosage Lethality22623531 No
    NQO2 Dosage Lethality22623531 No
    NR1H3 Dosage Lethality22623531 CHD related
    NTRK1 Dosage Lethality22623531 No
    PAK6 Dosage Lethality22623531 No
    PBK Dosage Lethality22623531 No
    PCBD1 Dosage Lethality22623531 No
    PDK1 Dosage Lethality22623531 No
    PES1 Dosage Lethality22623531 No
    PI4KB Dosage Lethality22623531 No
    PKN1 Dosage Lethality22623531 No
    POLA1 Dosage Lethality22623531 No
    POLH Dosage Lethality22623531 No
    POLR2E Dosage Lethality22623531 No
    POLR2I Dosage Lethality22623531 No
    PRC1 Dosage Lethality22623531 No
    PTP4A2 Dosage Lethality22623531 No
    PTPN9 Dosage Lethality22623531 No
    RAD21 Dosage Lethality22623531 No
    RASGRF1 Dosage Lethality22623531 No
    RASSF7 Dosage Lethality22623531 No
    REV1 Dosage Lethality22623531 No
    SCYL1 Dosage Lethality22623531 No
    SDC4 Dosage Lethality22623531 CHD related
    SH3KBP1 Dosage Lethality22623531 No
    SLC1A4 Dosage Lethality22623531 No
    SLC25A26 Dosage Lethality22623531 No
    SULF2 Dosage Lethality22623531 No
    SULT1A2 Dosage Lethality22623531 No
    SUV39H1 Dosage Lethality22623531 No
    TIE1 Dosage Lethality22623531 No
    TRIB1 Dosage Lethality22623531 CHD related
    TRIP13 Dosage Lethality22623531 No
    TXK Dosage Lethality22623531 No
    UBE2I Dosage Lethality22623531 No
    HAUS7 Dosage Lethality22623531 No
    WEE1 Dosage Lethality22623531 No
    WEE2 Dosage Lethality22623531 No
    WNK1 Dosage Lethality22623531 CHD related
    YES1 Dosage Lethality22623531 No
    ANGPTL4 Co-purification22573825 CHD related
    KDM5B Affinity Capture-Western22371483 No
    VHL Affinity Capture-Western22286234 No
    EBNA-3B/EBNA-3C Affinity Capture-Western18256156|18256156|18256156 No
    PML Affinity Capture-Western15735755|17146439|15735755 No
    PTPN11 Affinity Capture-Western17157259 CHD related
    MAP2K1 in vitro7957875 CHD related
    CDK1 in vivo1748630 CHD related
    TAF1B in vivo15723054 No
    ELF3 in vitro;in vivo1651323 No
    KIAA1524 in vitro;in vivo19470954,17632056 No
    DNMT3A Reconstituted Complex15616584|15616584|19786833|15616584 No
    BRCA1 Affinity Capture-Western11916966|14612409|14612409|9788437|9788437|20215511|20215511|12646176 CHD related
    BCL2 Affinity Capture-Western15210690|15210690|15210690 CHD related
    KAT5 Affinity Capture-Western12776177|20946988|12776177,15572685 No
    HSP90AA1 Affinity Capture-Western12644583 CHD related
    SMARCB1 Two-hybrid10319872|10319872|10319872 No
    GTF2I Reconstituted Complex8377829|8377829 No
    RB1 Two-hybrid7838535 CHD related
    PFDN5 Reconstituted Complex9792694|11585818|17728244|9792694,11567024 No
    PIAS2 Affinity Capture-Western11283613|18923429|17418410|20426839|19786833|16352593 No
    ZBTB17 Reconstituted Complex11283613|9312026|9312026|9312026|9312026,16352593 No
    NFYC Reconstituted Complex10446203|10446203|10446203|10446203,11282029 No
    CDC6 Reconstituted Complex10899308|10899308 No
    SP1 Affinity Capture-Western11274368|17418410 No
    YY1 Two-hybrid8266081|8266081|8266081 No
    NFYB Affinity Capture-Western11282029|11282029 No
    MYCBP2 Far Western9689053|9689053|9689053 No
    TP73 Affinity Capture-Western12080043|12080043,11844794 No
    MAPK8 Biochemical Activity10551811|10551811|10551811,1748630 CHD related
    UBB Affinity Capture-Western11046155|16247449 No
    FBXW7 Affinity Capture-Western17646408|15498494|15150404|15103331|20848231|16023596,17157259 No
    BRD7 Affinity Capture-Western20215511 No
    HUWE1 Reconstituted Complex16269333|16269333|16269333 No
    UBC Affinity Capture-Western16269333|12769844|19131971|21620836|21987572|20972266|21890473|21906983|22505724 No
    ATAD2 Affinity Capture-Western19843847|19843847 No
    SNW1 Affinity Capture-Western19818711 No
    HNRNPU Affinity Capture-Western19578763 No
    CREBBP Affinity Capture-Western16878156 No
    ESR1 Affinity Capture-Western16455494 CHD related
    SKP2 Affinity Capture-Western12769844|12963825 No
    PARP10 Affinity Capture-Western15674325|15674325|22992334 No
    MNT Affinity Capture-Western18271930 No
    HDAC1 Affinity Capture-Western18271930|18003922|22286234 CHD related
    PIM1 Affinity Capture-Western17643117 No
    C14orf169 Affinity Capture-Western17308053 No
    RPL11 Affinity Capture-Western17599065 No
    JUN Affinity Capture-Western20232342 CHD related
    DMAP1 Affinity Capture-Western20946988 No
    TRIP12 Reconstituted Complex20208519|20208519 No
    TUBA1A Affinity Capture-Western20691906|7651436 No
    TUBB Affinity Capture-Western20691906 No
    AXIN1 Affinity Capture-Western19131971|19131971 No
    IKBKG Affinity Capture-Western20970423 No
    SUMO2 Affinity Capture-MS21693764 No
    pin1-a Affinity Capture-Western15048125 No
    ELAVL1 Affinity Capture-RNA19322201 No
    PSMC5 Affinity Capture-Western12963825 No
    TFAP2C Phenotypic Enhancement22371483|22371483|22371483|22371483 No
    SIRT2 Negative Genetic22318606 No
    YEATS4 Reconstituted Complex22068108 No
    USP28 Biochemical Activity17558397|17558397 No
    TRIM6 Affinity Capture-Western22328504|22328504 No
    CDKN2A Affinity Capture-Western20308430|15361884 CHD related
    SNIP1 Two-hybrid17157259|17157259|17157259 No
    MXD1 in vitro;in vivo11602341 No
    TFAP2B in vitro;in vivo7729426 CHD related
    MAPK7 in vitro9461566 No
    TUBA3C in vitro;in vivo7651436 No
    TUBA1B in vitro;in vivo7651436 No
    TUBA8 in vitro;in vivo7651436 No
    RAGE in vitro10421840 No
    SPAG9 in vitro12391307 No
    MINA in vitro;in vivo12091391 No
    CSNK2A1 in vivo2663470 CHD related
    CSNK2A2 in vivo2663470 No
    MXI1 yeast 2-hybrid7565735 No
    PRDX1 in vitro;in vivo;yeast 2-hybrid12196529 CHD related


    Involved FDA drugs

    There was no drug associated with MYC