How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: NGF

    Description: nerve growth factor (beta polypeptide)

    Entrez Gene ID: 4803

    SwissProt Acc Number: P01138

    RefSeq: NM_002506

    It was suspected to be CHD related:

    ..Up-regulation of vascular andothelial growth factor (VEGF)-mediated signals and increased nerve growth factor (NGF) expression might be two of these important protective factors...

    From PMID: 17317457, in Journal Arch Gerontol Geriatr. , 2007


    References

    There were 13 potential papers with NGF and CHD.

    PMIDTitleJournalsDetails
    24051270 Local infiltration of neuropeptide Y as a potential therapeutic agent against apoptosis and fibrosis in a swine model of hypercholesterolemia and chronic myocardial ischemia.European journal of pharmacologyMore Details
    23872719 Antihyperalgesic and Anti-inflammatory Effects of Atorvastatin in Chronic Constriction Injury-Induced Neuropathic Pain in Rats.InflammationMore Details
    22359072 A cutting edge overview: psoriatic disease.Clinical reviews in allergy & immunologyMore Details
    23314533 Nerve growth factor reduces myocardial ischemia/reperfusion injury in rat hearts.Journal of basic and clinical physiology and pharmacologyMore Details
    22628392 Blockade of spinal nerves inhibits expression of neural growth factor in the myocardium at an early stage of acute myocardial infarction in rats.British journal of anaesthesiaMore Details
    22001051 Acute myocardial infarction induces bilateral stellate ganglia neural remodeling in rabbits.Cardiovascular pathology : the official journal of the Society for CardiovascularMore Details
    21679057 "Depot-specific overexpression of proinflammatory, redox, endothelial cell, and angiogenic genes in epicardial fat adjacent to severe stable coronary atherosclerosis."Metabolic syndrome and related disordersMore Details
    20360245 Nerve growth factor promotes cardiac repair following myocardial infarction.Circulation researchMore Details
    19286942 "Paraplegia increased cardiac NGF content, sympathetic tonus, and the susceptibility to ischemia-induced ventricular tachycardia in conscious rats."American journal of physiology. Heart and circulatory physiologyMore Details
    17317457 Oxidated low-density lipoproteins (oxLDL) and peroxides in plasma of Down syndrome patients.Archives of gerontology and geriatricsMore Details
    15939120 Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes.International journal of cardiologyMore Details
    14699970 Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: a role for NGF and BDNF in cardiovascular disease?Progress in brain researchMore Details
    11935372 "NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome."Archives of physiology and biochemistryMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 9 unique genes interacted with NGF. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    NGFR Reconstituted Complex14985763|11729324|14985763 No
    NTRK1 Reconstituted Complex14985763|11729324|11738045|10490030,14985763 No
    PLG in vitro;in vivo11729324 No
    MMP7 in vitro;in vivo11729324 CHD related
    NGF in vitro10708862,9351801 CHD related
    SORT1 Reconstituted Complex14985763 CHD related
    A2M Reconstituted Complex10681572 No
    CRYAB Protein-peptide17487982 No
    SORCS3 in vitro15710408 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB01407ClenbuterolUsed as a bronchodilator in the treatment of asthma patients. R03CC13;R03AC14