How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: NOX4

    Description: NADPH oxidase 4

    Entrez Gene ID: 50507

    SwissProt Acc Number: Q9NPH5

    RefSeq: NM_001143836

    It was suspected to be CHD related:

    .."NOX1, NOX2, and NOX4 are important sources of reactive oxygen species in the heart,"..

    From PMID: 22503554, in Journal Am J Pathol , 2012


    References

    There were 14 potential papers with NOX4 and CHD.

    PMIDTitleJournalsDetails
    23824729 Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.The American journal of clinical nutritionMore Details
    24051369 "Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia/reperfusion injury."Journal of molecular and cellular cardiologyMore Details
    23372061 Two-dimensional fluorescence in-gel electrophoresis of coronary restenosis tissues in minipigs: increased adipocyte fatty acid binding protein induces reactive oxygen species-mediated growth and migration in smooth muscle cells."Arteriosclerosis, thrombosis, and vascular biology"More Details
    22503554 NOX5 expression is increased in intramyocardial blood vessels and cardiomyocytes after acute myocardial infarction in humans.The American journal of pathologyMore Details
    20091890 S-allyl-L-cysteine sulfoxide inhibits tumor necrosis factor-alpha induced monocyte adhesion and intercellular cell adhesion molecule-1 expression in human umbilical vein endothelial cells."Anatomical record (Hoboken, N.J. : 2007)"More Details
    20413786 Silencing nox4 in the paraventricular nucleus improves myocardial infarction-induced cardiac dysfunction by attenuating sympathoexcitation and periinfarct apoptosis.Circulation researchMore Details
    20410198 Activation of mineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats.EndocrinologyMore Details
    19965776 The 5A apolipoprotein A-I mimetic peptide displays antiinflammatory and antioxidant properties in vivo and in vitro."Arteriosclerosis, thrombosis, and vascular biology"More Details
    20716294 Redox regulation of responses to hypoxia and NO-cGMP signaling in pulmonary vascular pathophysiology.Annals of the New York Academy of SciencesMore Details
    18687299 Expression of NADPH oxidases and enhanced H(2)O(2)-generating activity in human coronary artery endothelial cells upon induction with tumor necrosis factor-alpha.International immunopharmacologyMore Details
    17416605 TNF-alpha blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats.American journal of physiology. Heart and circulatory physiologyMore Details
    17531211 FcgammaRIIa mediates C-reactive protein-induced inflammatory responses of human vascular smooth muscle cells by activating NADPH oxidase 4.Cardiovascular researchMore Details
    15699275 Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease.CirculationMore Details
    15256399 Systemic regulation of vascular NAD(P)H oxidase activity and nox isoform expression in human arteries and veins."Arteriosclerosis, thrombosis, and vascular biology"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 1 unique genes interacted with NOX4. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    TLR4 in vitro;yeast 2-hybrid15356101 CHD related


    Involved FDA drugs

    There was no drug associated with NOX4