How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: NPPA

    Description: natriuretic peptide precursor A

    Entrez Gene ID: 4878

    SwissProt Acc Number: P01160

    RefSeq: NM_006172

    It was suspected to be CHD related:

    .."Atrial natriuretic peptide (ANP, also known as NPPA) and brain natriuretic peptide (BNP, also known as NPPB) have been determined as genetic factors for several diseases, including stroke and myocardial infarction, in human and rat models. "..

    From PMID: 22400494, in Journal DNA Cell Biol , 2012


    There were 8 potential papers with NPPA and CHD.

    24104878 A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease.Cardiovascular researchMore Details
    24227810 Natriuretic peptides in cardiovascular diseases: current use and perspectives.European heart journalMore Details
    22388798 Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.Pharmacogenetics and genomicsMore Details
    22400494 Potential association between frequent nonsynonymous variant of NPPA and cardioembolic stroke.DNA and cell biologyMore Details
    21276798 Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes.Journal of molecular and cellular cardiologyMore Details
    18212314 Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension.JAMA : the journal of the American Medical AssociationMore Details
    16721833 Natriuretic peptide Val7Met substitution and risk of coronary artery disease in Greek patients with familial hypercholesterolemia.Journal of clinical laboratory analysisMore Details
    15699455 Hypertension genes are genetic markers for insulin sensitivity and resistance.HypertensionMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 10 unique genes interacted with NPPA. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    EPB41 Reconstituted Complex12542678 No
    NPR3 Reconstituted Complex1309330|2169733 CHD related
    NPR2 Reconstituted Complex1309330 CHD related
    RORB Two-hybrid15604093|15604093 No
    HNF4A Two-hybrid15604093|15604093 No
    ESR1 Two-hybrid15604093|15604093 CHD related
    NR5A2 Two-hybrid15604093|15604093 No
    UBQLN4 Two-hybrid16713569 No
    MME in vitro2531377,9232196,2972276 No
    NPR1 in vivo12547834 CHD related

    Involved FDA drugs

    There was no drug associated with NPPA