How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: NPY

    Description: neuropeptide Y

    Entrez Gene ID: 4852

    SwissProt Acc Number: P01303

    RefSeq: NM_000905

    It was suspected to be CHD related:

    .."It appears that NPY may play a part in compensatory or detrimental remodeling of myocardial tissue subsequent to hemodynamic overload or myocardial infarction, and in angiogenic processes to regenerate myocardium after ischemic injury."..

    From PMID: 17979778, in Journal Curr Top Med Chem. , 2007


    References

    There were 14 potential papers with NPY and CHD.

    PMIDTitleJournalsDetails
    24077326 The relationship of plasma neuropeptide Y levels with coronary collateral development.Coronary artery diseaseMore Details
    24005254 Invited Review EB 2012: Peripheral cardiac sympathetic hyperactivity in cardiovascular disease: role of neuropeptides."American journal of physiology. Regulatory, integrative and comparative"More Details
    24051270 Local infiltration of neuropeptide Y as a potential therapeutic agent against apoptosis and fibrosis in a swine model of hypercholesterolemia and chronic myocardial ischemia.European journal of pharmacologyMore Details
    22308535 Neuropeptide Y Leu7Pro polymorphism associated with the metabolic syndrome and its features in patients with coronary artery disease.AngiologyMore Details
    22289186 High frequency of Neuropeptide Y Leu7Pro polymorphism in an Iranian population and its association with coronary artery disease.GeneMore Details
    22017530 Differential effects of metoprolol and atenolol to neuropeptide Y blockade in coronary artery disease.Scandinavian cardiovascular journal : SCJMore Details
    22982235 Neuropeptide Y improves myocardial perfusion and function in a swine model of hypercholesterolemia and chronic myocardial ischemia.Journal of molecular and cellular cardiologyMore Details
    20826160 Effects of neuropeptide Y on collateral development in a swine model of chronic myocardial ischemia.Journal of molecular and cellular cardiologyMore Details
    19119412 Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.PLoS geneticsMore Details
    18054939 Neuropeptide Y signal peptide Pro7 substitution protects against coronary artery atherosclerosis: the Helsinki Sudden Death Study.AtherosclerosisMore Details
    17056830 Ventricular fibrillation induced by ischemia-reperfusion is not prevented by the NPY Y2 receptor antagonist BIIE0246.Journal of cardiovascular pharmacology and therapeuticsMore Details
    15847953 The T1128C polymorphism of neuropeptide Y gene in a chinese population.Archives of medical researchMore Details
    15240408 Cardiac sympathetic nerve biology and brain monoamine turnover in panic disorder.Annals of the New York Academy of SciencesMore Details
    11914038 Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease.Molecular genetics and metabolismMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 12 unique genes interacted with NPY. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    NPY1R Reconstituted Complex7559383 CHD related
    MC4R in vitro;in vivo12015205 CHD related
    PMCH Phenotypic Enhancement12106685|12106685 No
    MEP1A Biochemical Activity11278902 No
    NR1H2 Two-hybrid15604093 CHD related
    PPYR1 in vitro7493937 No
    NPY2R in vivo9001438,7559383,12007534 No
    MEP1B in vitro11278902 No
    NPY5R in vivo12007534 CHD related
    GHRL in vivo11196643,12663466 CHD related
    NPFF in vivo11325787 No
    NPFFR2 in vivo12609745 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    experimentalDB02952Alpha-Aminoisobutyric Acid
    experimentalDB03380L-Tyrosinamide