How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.

How To contact Us

Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

Website using assistance : Leihong Wu (11019004@zju.edu.cn)

Basic Information

Gene Name: NT5E

Description: 5'-nucleotidase, ecto (CD73)

This suspected gene is newly curated in the Version 2.0

It was suspected to be CHD related:

..Our data epitomize the importance of vascular CD73 in limiting endothelial activation and monocyte recruitment via generation of adenosine acting through the A2A receptor, providing a molecular basis for therapeutic protection against vascular inflammation and neointimal hyperplasia...

From PMID: 16636171, in Journal Circulation. 2006;113:2120-2127 ,

References

There were 0 potential papers with NT5E and CHD.

NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

PPI interactions

There were totally 10 unique genes interacted with NT5E. Show PPI network

Gene name	Interaction type	reference PMID	CHD relation
SLC30A5	Co-fractionation	22939629	No
NDUFA2	Co-fractionation	22939629	No
SYNJ2BP	Co-fractionation	22939629	No
PCDH7	Co-fractionation	22939629	No
TMEM177	Co-fractionation	22939629	No
ACTB	in vivo	10470109	No
FN1	in vivo	9361795,10470109	CHD related
AFF1	Two-hybrid	19956800	No
UBC	Affinity Capture-MS	21906983	No
LAMA1	in vivo	10470109	CHD related

Involved FDA drugs

There was no drug associated with NT5E

Design by WLH