How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: OLR1

    Description: oxidized low density lipoprotein (lectin-like) receptor 1

    Entrez Gene ID: 4973

    SwissProt Acc Number: P78380

    RefSeq: NM_002543

    It was suspected to be CHD related:

    .."The combined group samples identified 6 up regulated differential expression (DE) genes (GHRL, LTA, CBS, HP, ITGA2B, and OLR1) and 12 down regulated DE genes (IL18R1, ITGA2B, IL18RAP, HP, OLR1, SOD2 ITGB3, IL1B, MMP9, PLA2G7, UTS2, and CBS) to be involved in CAD at the fold change of 1.3 with fault discovery rate (FDR) of 1%.//Our results do not support the presence of an association between selected common SNPs in OLR1 and the risk of clinical CAD."..

    From PMID: 22738689, in Journal J Cardiol.? , 2012


    References

    There were 13 potential papers with OLR1 and CHD.

    PMIDTitleJournalsDetails
    23391848 "OLR1, PON1 and MTHFR gene polymorphisms, conventional risk factors and the severity of coronary atherosclerosis in a Chinese Han population."Cellular physiology and biochemistry : international journal of experimentalMore Details
    22738689 Peripheral blood gene expression profile of atherosclerotic coronary artery disease in patients of different ethnicity in Malaysia.Journal of cardiologyMore Details
    21252261 Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study.Journal of lipid researchMore Details
    21912121 Associations between oxidized-lipoprotein receptor 1 G501C and 3'-UTR-C188T polymorphisms and coronary artery disease: a meta-analysis.CardiologyMore Details
    19929426 IVS4-14 A/G and IVS4-73 C/T polymorphisms in OLR1 gene in patients with ischemic cerebrovascular diseases.Genetic testing and molecular biomarkersMore Details
    22371740 Genetic variability and the risk of myocardial infarction in Poles under 45 years of age.Archives of medical science : AMSMore Details
    19961348 Population differences in allele frequencies at the OLR1 locus may suggest geographic disparities in cardiovascular risk events.Annals of human biologyMore Details
    18384690 Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD.BMC medical geneticsMore Details
    17312010 Robust immunohistochemical staining of several classes of proteins in tissues subjected to autolysis.The journal of histochemistry and cytochemistry : official journal of theMore Details
    16829343 The 3'-UTR C>T polymorphism of the oxidized LDL-receptor 1 (OLR1) gene does not associate with coronary artery disease in Italian CAD patients or with the severity of coronary disease."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    16251892 On the association of the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction or coronary artery disease.European journal of human genetics : EJHGMore Details
    15976314 In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction.Circulation researchMore Details
    12810610 Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease.CirculationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 3 unique genes interacted with OLR1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    UBC Affinity Capture-MS21987572 No
    ELAVL1 Affinity Capture-RNA19322201 No
    HSPA4 in vitro15792802 No


    Involved FDA drugs

    There was no drug associated with OLR1