How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: P2RY1

    Description: "purinergic receptor P2Y, G-protein coupled, 1"

    Entrez Gene ID: 5028

    SwissProt Acc Number: P47900

    RefSeq: NM_002563

    It was supported literatures to be a novel CHD related gene:

    ..Polymorphisms in P2RY1 and P2RY12 are associated with on-aspirin platelet reactivity in patients with CAD...

    From PMID: 22574824, in Journal Int J Lab Hematol. , 2012


    References

    There were 3 potential papers with P2RY1 and CHD.

    PMIDTitleJournalsDetails
    22574824 P2RY1 and P2RY12 polymorphisms and on-aspirin platelet reactivity in patients with coronary artery disease.International journal of laboratory hematologyMore Details
    21429568 Genetic determinants of response to aspirin: appraisal of 4 candidate genes.Thrombosis researchMore Details
    19637098 "Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3."PlateletsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 3 unique genes interacted with P2RY1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    ADORA1 Affinity Capture-Western11390975|11390975 CHD related
    SLC9A3R1 Reconstituted Complex9671706 No
    SLC9A3R2 in vitro9671706 No


    Involved FDA drugs

    There was no drug associated with P2RY1