How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: PAR4

    Description: Prader-Willi/Angelman region gene 4

    Entrez Gene ID: 347745

    SwissProt Acc Number:

    RefSeq: NR_022010

    It was supported literatures to be a novel CHD related gene:

    .."These results define a novel, shear-regulated role for thrombin/PAR-dependent platelet activation during thrombosis and provide important insights into the conditions under which PAR antagonists may best be used for the prevention of acute coronary syndromes."..

    From PMID: 22187047, in Journal Thromb Haemost. , 2012


    References

    There were 5 potential papers with PAR4 and CHD.

    PMIDTitleJournalsDetails
    22228373 Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury.American journal of hematologyMore Details
    18436807 Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice."Arteriosclerosis, thrombosis, and vascular biology"More Details
    17151288 Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway.Molecular pharmacologyMore Details
    16837456 "PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation."The Journal of biological chemistryMore Details
    16930224 Inhibition of PAR4 signaling mediates ethanol-induced attenuation of platelet function in vitro."Alcoholism, clinical and experimental research"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There was NO PPI interaction information about PAR4



    Involved FDA drugs

    There was no drug associated with PAR4