How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: PEAR1

    Description: platelet endothelial aggregation receptor 1

    Entrez Gene ID: 375033

    SwissProt Acc Number: Q5VY43

    RefSeq: NM_001080471

    It was supported literatures to be a novel CHD related gene:

    ..PEAR1 appears to play an important role in agonist-induced platelet aggregation and in the response to ASA in both whites and blacks...

    From PMID: 18511696, in Journal Arterioscler Thromb Vasc Biol. , 2008


    References

    There were 4 potential papers with PEAR1 and CHD.

    PMIDTitleJournalsDetails
    23392654 Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.Circulation. Cardiovascular geneticsMore Details
    21791418 Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression.BloodMore Details
    21742104 Polymorphisms associated with in vitro aspirin resistance are not associated with clinical outcomes in patients with coronary artery disease who report regular aspirin use.American heart journalMore Details
    18511696 A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability."Arteriosclerosis, thrombosis, and vascular biology"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There was NO PPI interaction information about PEAR1



    Involved FDA drugs

    There was no drug associated with PEAR1