How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: PLA2G7

    Description: "phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)"

    Entrez Gene ID: 7941

    SwissProt Acc Number: Q13093

    RefSeq: NM_001168357

    It was suspected to be CHD related:

    ..A meta-analysis was conducted to assess the effect of PLA2G7 gene on CHD. The results indicate 92H allele had probably increased the risk of CHD..

    From PMID: 20926117, in Journal Thromb Res.? , 2010


    References

    There were 19 potential papers with PLA2G7 and CHD.

    PMIDTitleJournalsDetails
    23404648 An association study between genetic polymorphisms related to lipoprotein-associated phospholipase A(2) and coronary heart disease.Experimental and therapeutic medicineMore Details
    23592636 Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine.Physiological genomicsMore Details
    23555769 Elevated PLA2G7 gene promoter methylation as a gender-specific marker of aging increases the risk of coronary heart disease in females.PloS oneMore Details
    22738689 Peripheral blood gene expression profile of atherosclerotic coronary artery disease in patients of different ethnicity in Malaysia.Journal of cardiologyMore Details
    21606947 Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations.The pharmacogenomics journalMore Details
    22003152 Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.European heart journalMore Details
    22340269 Translational studies of lipoprotein-associated phospholipase A(2) in inflammation and atherosclerosis.Journal of the American College of CardiologyMore Details
    21834908 Association between lipoprotein-associated phospholipase A2 gene polymorphism and coronary artery disease in the Chinese Han population.Annals of human geneticsMore Details
    21130994 Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction.AtherosclerosisMore Details
    21490708 Carriage of the V279F null allele within the gene encoding Lp-PLA(2) is protective from coronary artery disease in South Korean males.PloS oneMore Details
    20479152 "PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry."CirculationMore Details
    20926117 PLA2G7 gene polymorphisms and coronary heart disease risk: a meta-analysis.Thrombosis researchMore Details
    18983494 Genetic variants and haplotypes of lipoprotein associated phospholipase A2 and their influence on cardiovascular disease (The Ludwigshafen Risk and Cardiovascular Health Study).Journal of thrombosis and haemostasis : JTHMore Details
    19034521 Associations of PLA2G7 gene polymorphisms with plasma lipoprotein-associated phospholipase A2 activity and coronary heart disease in a Chinese Han population: the Beijing atherosclerosis study.Human geneticsMore Details
    19948975 Integrative predictive model of coronary artery calcification in atherosclerosis.CirculationMore Details
    18204052 Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets.Human molecular geneticsMore Details
    18001304 Two new highly polymorphic markers in the 3' UTR region of the PLA2G7 gene.International journal of immunogeneticsMore Details
    16438975 Lp-PLA2 activity and PLA2G7 A379V genotype in patients with diabetes mellitus.AtherosclerosisMore Details
    15115767 Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease.Human molecular geneticsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 1 unique genes interacted with PLA2G7. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    TUBA1A in vitro;in vivo9384577 No


    Involved FDA drugs

    There was no drug associated with PLA2G7