How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: PLTP

    Description: phospholipid transfer protein

    Entrez Gene ID: 5360

    SwissProt Acc Number: P55058

    RefSeq: NM_006227

    It was suspected to be CHD related:

    ..The serum PLTP levels of CHD patients of sthenia in superficiality significantly increased...

    From PMID: 21823416, in Journal Zhongguo Zhong Xi Yi Jie He Za Zhi.? , ?2011


    References

    There were 18 potential papers with PLTP and CHD.

    PMIDTitleJournalsDetails
    23545183 High PLTP activity is associated with depressed left ventricular systolic function.AtherosclerosisMore Details
    22897926 The impact of phospholipid transfer protein (PLTP) on lipoprotein metabolism.Nutrition & metabolismMore Details
    21347282 "Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project."PLoS geneticsMore Details
    19876761 Protective modulation of carotid atherosclerosis in hyperalphalipoproteinemic individuals.The international journal of cardiovascular imagingMore Details
    20108050 Serum phospholipid transfer protein activity after a high fat meal in patients with insulin-treated type 2 diabetes.LipidsMore Details
    19446293 Relation of baseline plasma phospholipid transfer protein (PLTP) activity to left ventricular systolic dysfunction in patients referred for coronary angiography.AtherosclerosisMore Details
    19135989 Reverse modulation of the HDL anionic peptide factor and phospholipid transfer protein activity in coronary artery disease and type 2 diabetes mellitus.Clinical biochemistryMore Details
    19001358 PLTP activity is a risk factor for subsequent cardiovascular events in CAD patients under statin therapy: the AtheroGene study.Journal of lipid researchMore Details
    19023137 The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis.Journal of lipid researchMore Details
    19627602 Haptoglobin inhibits phospholipid transfer protein activity in hyperlipidemic human plasma.Lipids in health and diseaseMore Details
    19948027 Plasma PLTP activity is inversely associated with HDL-C levels.Nutrition & metabolismMore Details
    18826383 SAA and PLTP activity in plasma of periodontal patients before and after full-mouth tooth extraction.Oral diseasesMore Details
    17553507 Low phospholipid transfer protein (PLTP) is a risk factor for peripheral atherosclerosis.AtherosclerosisMore Details
    17928634 Macrophage PLTP is atheroprotective in LDLr-deficient mice with systemic PLTP deficiency.Journal of lipid researchMore Details
    15694928 Lipid transfer proteins (LTP) and atherosclerosis.AtherosclerosisMore Details
    13130123 Periodontitis decreases the antiatherogenic potency of high density lipoprotein.Journal of lipid researchMore Details
    12947020 High plasma phospholipid transfer protein levels as a risk factor for coronary artery disease."Arteriosclerosis, thrombosis, and vascular biology"More Details
    12835223 Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis.CirculationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 4 unique genes interacted with PLTP. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    APOA1 Reconstituted Complex9469594 CHD related
    APOA2 Reconstituted Complex9469594|9469594 CHD related
    ABCA1 in vitro14559902 CHD related
    APOE Affinity Capture-Western12810820 CHD related


    Involved FDA drugs

    There was no drug associated with PLTP