How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: PON1

    Description: paraoxonase 1

    Entrez Gene ID: 5444

    SwissProt Acc Number: P27169

    RefSeq: NM_000446

    It was suspected to be CHD related:

    ..Human paraoxonase 1 (PON1) is a calcium-dependent high-density lipoprotein associated ester hydrolase that has attracted considerable attention as a candidate factor for coronary heart disease (CHD) based on its function as a key factor in lipoprotein catabolism pathways..

    From PMID: 22320866, in Journal DNA Cell Biol. , 2012


    There were 132 potential papers with PON1 and CHD.

    24009042 Enhanced active metabolite generation and platelet inhibition with prasugrel compared to clopidogrel regardless of genotype in thienopyridine metabolic pathways.Thrombosis and haemostasisMore Details
    24280342 Activation of paraoxonase 1 is associated with HDL remodeling ex vivo.Clinica chimica acta; international journal of clinical chemistryMore Details
    23742759 Associations between genetic polymorphisms of paraoxonase genes and coronary artery disease in a Taiwanese population.Clinical biochemistryMore Details
    23869295 "Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia."Indian journal of endocrinology and metabolismMore Details
    23998046 The role of 'paraoxonase-1 activity' as an antioxidant in coronary artery diseases.Journal of clinical and diagnostic research : JCDRMore Details
    23901196 The determination of Q192R polymorphism of paraoxonase 1 by using non-toxic substrate p-nitrophenylacetate.Indian journal of human geneticsMore Details
    23515649 "Paraoxonase-1 (PON1) promoter region polymorphisms, serum PON1 status and coronary heart disease."Archives of medical science : AMSMore Details
    23171143 Association of paraoxonase1 gene Q192R polymorphism and apolipoprotein B in Asian Indian women with coronary artery disease risk.Genetic testing and molecular biomarkersMore Details
    23053877 Association of PON1 and PON2 polymorphisms with PON1 activity and significant coronary stenosis in a Tunisian population.Biochemical geneticsMore Details
    23625196 The Q192R polymorphism of the paraoxonase 1 gene is a risk factor for coronary artery disease in Saudi subjects.Molecular and cellular biochemistryMore Details
    23608957 Association of PON1 genotype and haplotype with susceptibility to coronary artery disease and clinical outcomes in dual antiplatelet-treated Han Chinese patients.European journal of clinical pharmacologyMore Details
    22669508 "Paraoxonase 1, atherosclerosis and arterial stiffness in renal patients."International urology and nephrologyMore Details
    23391848 "OLR1, PON1 and MTHFR gene polymorphisms, conventional risk factors and the severity of coronary atherosclerosis in a Chinese Han population."Cellular physiology and biochemistry : international journal of experimentalMore Details
    23382833 Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease.PloS oneMore Details
    23418418 Paraoxonase 1 gene polymorphism does not affect clopidogrel response variability but is associated with clinical outcome after PCI.PloS oneMore Details
    24167353 Reduced paraoxonase 1 activity as a marker for severe coronary artery disease.Disease markersMore Details
    22901080 Ultrasensitive assay for detection of serum paraoxonase by modulating the growth of fluorescent semiconductor nanoparticles.Analytical chemistryMore Details
    22750797 Two- and three-locus haplotypes of the paraoxonase (PON1) gene are associated with coronary artery disease in Asian Indians.GeneMore Details
    22402736 Diet-induced weight loss in overweight or obese women and changes in high-density lipoprotein levels and function."Obesity (Silver Spring, Md.)"More Details
    22643843 Paraoxonase 1 and homocysteine metabolism.Amino acidsMore Details
    23181222 Antioxidant and anti-inflammatory role of paraoxonase 1: implication in arteriosclerosis diseases.North American journal of medical sciencesMore Details
    22388798 Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.Pharmacogenetics and genomicsMore Details
    21867409 The human paraoxonase gene cluster as a target in the treatment of atherosclerosis.Antioxidants & redox signalingMore Details
    21681430 Synergism between paraoxonase Arg 192 and the angiotensin converting enzyme D allele is associated with severity of coronary artery disease.Molecular biology reportsMore Details
    22320866 Quantitative assessment of the influence of paraoxonase 1 activity and coronary heart disease risk.DNA and cell biologyMore Details
    22030099 Association between PON1 activity and coronary heart disease risk: a meta-analysis based on 43 studies.Molecular genetics and metabolismMore Details
    22333293 Low serum PON1 activity: an independent risk factor for coronary artery disease in North-West Indian type 2 diabetics.GeneMore Details
    22621394 Evaluation of the future atherosclerotic heart disease with oxidative stress and carotid artery intima media thickness in gestational diabetes mellitus.Endocrine researchMore Details
    22723959 Paraoxonase-1 is not a major determinant of stent thrombosis in a Taiwanese population.PloS oneMore Details
    22427735 Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response.Clinical pharmacology : advances and applicationsMore Details
    21960992 Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery disease.Experimental diabetes researchMore Details
    22846213 Paraoxonase-1 is not associated with coronary artery calcification in type 2 diabetes: results from the PREDICT study.Disease markersMore Details
    22548179 Regulation of hepatic paraoxonase-1 expression.Journal of lipidsMore Details
    21567207 Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease.Molecular and cellular biochemistryMore Details
    22123566 [Paraoxonase-1 (PON1) activity in patients with coronary artery diseases and in diabetic patients].Annales de biologie cliniqueMore Details
    21748243 "Plasma paraoxonase-1, oxidized low-density lipoprotein and lipid peroxidation levels in gout patients."Cell biochemistry and biophysicsMore Details
    21982484 Interaction of folate intake and the paraoxonase Q192R polymorphism with risk of incident coronary heart disease and ischemic stroke: the atherosclerosis risk in communities study.Annals of epidemiologyMore Details
    21465165 Paraoxonase Arg 192 allele is an independent risk factor for three-vessel stenosis of coronary artery disease.Molecular biology reportsMore Details
    21231776 C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging.Scandinavian journal of clinical and laboratory investigationMore Details
    22109721 Frequency distribution of the single-nucleotide -108C/T polymorphism at the promoter region of the PON1 gene in Asian Indians and its relationship with coronary artery disease.Journal of community geneticsMore Details
    21287574 "First survey of the three gene polymorphisms (PON1 Q192R, eNOS E298D and eNOS C-786T) potentially associated with coronary artery spasm in African populations and comparison with worldwide data."Cell biochemistry and functionMore Details
    21438666 Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes.Genetic testing and molecular biomarkersMore Details
    21527445 No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting.European heart journalMore Details
    21701074 PON-dering differences in HDL function in coronary artery disease.The Journal of clinical investigationMore Details
    21701070 Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease.The Journal of clinical investigationMore Details
    21170047 Paraoxonase-1 is a major determinant of clopidogrel efficacy.Nature medicineMore Details
    20820904 PON1 55 and 192 gene polymorphisms in type 2 diabetes mellitus patients in a Turkish population.Biochemical geneticsMore Details
    21146823 Four genetic polymorphisms of paraoxonase gene and risk of coronary heart disease: a meta-analysis based on 88 case-control studies.AtherosclerosisMore Details
    21450592 "Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease."European journal of cardiovascular prevention and rehabilitation : officialMore Details
    21543280 Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik.Environmental health perspectivesMore Details
    21620813 Polymorphisms of pon1 and pon2 genes in hemodialyzed patients.Clinical biochemistryMore Details
    21252261 Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study.Journal of lipid researchMore Details
    21629682 "Paraoxonase 1 (PON1) polymorphisms, haplotypes and activity in predicting cad risk in North-West Indian Punjabis."PloS oneMore Details
    21223581 Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.BMC medical geneticsMore Details
    22214423 Effects of paraoxonase activity and gene polymorphism on coronary vasomotion.EJNMMI researchMore Details
    20856122 Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis.Genetics in medicine : official journal of the American College of MedicalMore Details
    20012900 Is alcohol beneficial or harmful for cardioprotection?Genes & nutritionMore Details
    19939821 The role of polymorphisms within paraoxonases (192 Gln/Arg in PON1 and 311Ser/Cys in PON2) in the modulation of cardiovascular risk: a pilot study.AngiologyMore Details
    20485444 "Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population."Journal of human geneticsMore Details
    20026099 The relationship between paraoxonase1-192 polymorphism and activity with coronary artery disease.Clinical biochemistryMore Details
    20872564 Matrix metalloproteinase-9 and paraoxonase 1 Q/R192 gene polymorphisms and the risk of coronary artery stenosis in Iranian subjects.Journal of clinical laboratory analysisMore Details
    23105865 Relationship between PON1L55M and Q192R gene polymorphisms and high APO B/APO A-I ratios.Indian journal of clinical biochemistry : IJCBMore Details
    19219535 "Association of genetic variants in Methylenetetrahydrofolate Reductase and Paraoxonase-1 genes with homocysteine, folate and vitamin B12 in coronary artery disease."Molecular and cellular biochemistryMore Details
    19269283 Association of homocysteine thiolactonase activity and PON1 polymorphisms with the severity of acute coronary syndrome.Clinical biochemistryMore Details
    19843623 Effect of preoperative atorvastatin therapy on paraoxonase activity and oxidative stress after coronary artery bypass grafting.PerfusionMore Details
    19948975 Integrative predictive model of coronary artery calcification in atherosclerosis.CirculationMore Details
    19426787 Molecular characterization and expression analysis of the porcine paraoxonase 3 (PON3) gene.GeneMore Details
    19770524 Paraoxonase 1 gene polymorphisms contribute to coronary artery disease risk among north Indians.Indian journal of medical sciencesMore Details
    19710913 Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study.PloS oneMore Details
    19275503 Novel serum paraoxonase activity assays are associated with coronary artery disease.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    18433845 Paraoxonase 1 gene promoter polymorphisms are associated with the extent of stenosis in coronary arteries.Thrombosis researchMore Details
    18937674 Glycation of paraoxonase-1 inhibits its activity and impairs the ability of high-density lipoprotein to metabolize membrane lipid hydroperoxides.Diabetic medicine : a journal of the British Diabetic AssociationMore Details
    18634772 PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients.Clinical biochemistryMore Details
    18582459 PON1Q192R polymorphism is associated with lipid profile in Mexican men with Mayan ascendancy.Experimental and molecular pathologyMore Details
    18349088 Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk.JAMA : the journal of the American Medical AssociationMore Details
    17900266 Genetic variation in the paraoxonase-3 (PON3) gene is associated with serum PON1 activity.Annals of human geneticsMore Details
    17683517 The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics.Annals of human geneticsMore Details
    19005291 The relationships between PON1 activity as well as oxLDL levels and coronary artery lesions in CHD patients with diabetes mellitus or impaired fasting glucose.Coronary artery diseaseMore Details
    18430057 Effect of statin therapy on plasma high-density lipoprotein-cholesterol levels is modified by paraoxonase 1 in Chinese patients with coronary heart disease.Clinical and experimental pharmacology & physiologyMore Details
    18164014 Paraoxonase (PON1) and the risk for coronary heart disease and myocardial infarction in a general population of Dutch women.AtherosclerosisMore Details
    18403458 Effect of statins on serum apolipoprotein j and paraoxonase-1 levels in patients with ischemic heart disease undergoing coronary angiography.AngiologyMore Details
    18281420 "Factors associated with paraoxonase genotypes and activity in a diverse, young, healthy population: the Coronary Artery Risk Development in Young Adults (CARDIA) study."Clinical chemistryMore Details
    18601602 High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    17525004 PON1 activity is inversely related to LDL apoB carbonyl content in patients with coronary artery disease.The Kaohsiung journal of medical sciencesMore Details
    17560461 Synergistic effects between Q192R polymorphism of paraoxonase 1 gene and some conventional risk factors in premature coronary artery disease.Archives of medical researchMore Details
    17587252 PON1 activity and genotype in patients with arterial ischemic stroke and in healthy individuals.Acta neurologica ScandinavicaMore Details
    17185369 Accuracy and biological variation of human serum paraoxonase 1 activity and polymorphism (Q192R) by kinetic enzyme assay.Clinical chemistryMore Details
    17473052 Exercise and diet induced weight loss improves measures of oxidative stress and insulin sensitivity in adults with characteristics of the metabolic syndrome.American journal of physiology. Endocrinology and metabolismMore Details
    17437735 Polymorphisms in the paraoxonase and endothelial nitric oxide synthase genes and the risk of early-onset myocardial infarction.The American journal of cardiologyMore Details
    17617030 Paraoxonase 1 gene polymorphisms in angiographically assessed coronary artery disease: evidence for gender interaction among Brazilians.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    17065348 Defective metabolism of oxidized phospholipid by HDL from people with type 2 diabetes.DiabetesMore Details
    16185677 Detecting the polymorphisms of paraoxonase (PON) cluster in Chinese Han population based on a rapid method.Clinica chimica acta; international journal of clinical chemistryMore Details
    16423902 Semiautomated method for determination of serum paraoxonase activity using paraoxon as substrate.Clinical chemistryMore Details
    16327022 Paraoxonase-1 and serum concentrations of HDL-cholesterol and apoA-I.Journal of lipid researchMore Details
    16781370 Association of paraoxonase-1 activity and concentration with angiographic severity and extent of coronary artery disease.Journal of the American College of CardiologyMore Details
    16140307 High C-reactive protein and low paraoxonase1 in diabetes as risk factors for coronary heart disease.AtherosclerosisMore Details
    16729301 Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus.Arthritis and rheumatismMore Details
    16940704 Impact of paraoxonase polymorphism (Q192R) on endothelial function in intact coronary circulation.Hypertension research : official journal of the Japanese Society of HypertensionMore Details
    16808888 "Human serum paraoxonase gene polymorphisms, Q192R and L55M, are not associated with the risk of cerebral infarction in Chinese Han population."Neurological researchMore Details
    16319130 Polymorphisms in the PON gene cluster are associated with Alzheimer disease.Human molecular geneticsMore Details
    16155079 Decreased serum paraoxonase 1 (PON1) activity: an additional risk factor for atherosclerotic heart disease in patients with PCOS?"Human reproduction (Oxford, England)"More Details
    16875684 "Hyperhomocysteinemia, paraoxonase activity and risk of coronary artery disease."Clinical biochemistryMore Details
    17032132 "Paraoxonase-1 (PON1) activity, but not PON1(Q192R) phenotype, is a predictor of coronary artery disease in a middle-aged Serbian population."Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    16239632 Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke.Stroke; a journal of cerebral circulationMore Details
    15928879 Interaction between metabolic syndrome and PON1 polymorphisms as a determinant of the risk of coronary artery disease.Clinical and experimental medicineMore Details
    15309416 Paraoxonase activity in Greek migrants and Anglo-Celtic persons in the Melbourne Collaborative Cohort Study: relationship to dietary markers.European journal of nutritionMore Details
    15654230 "PON1 polymorphism, diabetes mellitus, obesity, and risk of myocardial infarction: Modifying effect of diabetes mellitus and obesity on the association between PON1 polymorphism and myocardial infarction."Genetics in medicine : official journal of the American College of MedicalMore Details
    16411410 Endurance training reduces circulating asymmetric dimethylarginine and myeloperoxidase levels in persons at risk of coronary events.Thrombosis and haemostasisMore Details
    15681296 Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations."Arteriosclerosis, thrombosis, and vascular biology"More Details
    15241482 Paraoxonase 1 polymorphisms and survival.European journal of human genetics : EJHGMore Details
    15454272 Paraoxonase 1 and atherosclerosis: is the gene or the protein more important?Free radical biology & medicineMore Details
    15265000 Genetic and environmental factors modulating serum concentrations and activities of the antioxidant enzyme paraoxonase-1."Clinical science (London, England : 1979)"More Details
    15089785 "Smoking is associated with reduced serum levels of the antioxidant enzyme, paraoxonase, in Type 2 diabetic patients."Diabetic medicine : a journal of the British Diabetic AssociationMore Details
    15087255 The paraoxonase promoter polymorphism (-107)T>C is not associated with carotid intima-media thickness in Sicilian hypercholesterolemic patients.Clinical biochemistryMore Details
    15135268 Genetic risk for restenosis after coronary balloon angioplasty.AtherosclerosisMore Details
    14996478 PON1 M/L55 mutation protects high-risk patients against coronary artery disease.International journal of cardiologyMore Details
    15214960 The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis.BMC geneticsMore Details
    15158307 "Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation.""Clinical nutrition (Edinburgh, Scotland)"More Details
    15001326 Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies.LancetMore Details
    15050299 Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis.Experimental gerontologyMore Details
    14500290 Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2."Arteriosclerosis, thrombosis, and vascular biology"More Details
    12756158 Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study.CirculationMore Details
    12454802 "Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study."American journal of human geneticsMore Details
    14551701 "Paraoxonase gene polymorphisms, oxidative stress, and diseases.""Journal of molecular medicine (Berlin, Germany)"More Details
    12525679 "Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism."Annual review of medicineMore Details
    11810302 Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm.Human geneticsMore Details
    12474066 Paraoxonase 1 Q192R (PON1-192) polymorphism is associated with reduced lipid peroxidation in R-allele-carrier but not in QQ homozygous elderly subjects on a tomato-rich diet.European journal of nutritionMore Details
    12417809 Human paraoxonase 1 gene polymorphisms and the risk of coronary heart disease: a community-based study.CardiologyMore Details
    11803456 Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias.Molecular psychiatryMore Details
    11230170 A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation.Genome researchMore Details
    11409295 Paraoxonase 1 192 Gln/Arg gene polymorphism and cerebrovascular disease: interaction with type 2 diabetes."Experimental and clinical endocrinology & diabetes : official journal, German"More Details
    11096050 Genetic polymorphism in paraoxonase is a risk factor for childhood focal segmental glomerulosclerosis.American journal of kidney diseases : the official journal of the National KidneyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 4 unique genes interacted with PON1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    APOA1 in vitro16128586 CHD related
    ALB in vitro6324579 CHD related
    SUMO4 Affinity Capture-MS16236267 CHD related
    CLU Affinity Capture-Western8292612|8292612 No

    Involved FDA drugs

    There was no drug associated with PON1