Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: paraoxonase 1
Entrez Gene ID: 5444
SwissProt Acc Number: P27169
RefSeq: NM_000446
It was suspected to be CHD related:
..Human paraoxonase 1 (PON1) is a calcium-dependent high-density lipoprotein associated ester hydrolase that has attracted considerable attention as a candidate factor for coronary heart disease (CHD) based on its function as a key factor in lipoprotein catabolism pathways..
From PMID: 22320866, in Journal DNA Cell Biol. , 2012There were 132 potential papers with PON1 and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 24009042 | Enhanced active metabolite generation and platelet inhibition with prasugrel compared to clopidogrel regardless of genotype in thienopyridine metabolic pathways. | Thrombosis and haemostasis | More Details |
| 24280342 | Activation of paraoxonase 1 is associated with HDL remodeling ex vivo. | Clinica chimica acta; international journal of clinical chemistry | More Details |
| 23742759 | Associations between genetic polymorphisms of paraoxonase genes and coronary artery disease in a Taiwanese population. | Clinical biochemistry | More Details |
| 23869295 | "Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia." | Indian journal of endocrinology and metabolism | More Details |
| 23998046 | The role of 'paraoxonase-1 activity' as an antioxidant in coronary artery diseases. | Journal of clinical and diagnostic research : JCDR | More Details |
| 23901196 | The determination of Q192R polymorphism of paraoxonase 1 by using non-toxic substrate p-nitrophenylacetate. | Indian journal of human genetics | More Details |
| 23515649 | "Paraoxonase-1 (PON1) promoter region polymorphisms, serum PON1 status and coronary heart disease." | Archives of medical science : AMS | More Details |
| 23171143 | Association of paraoxonase1 gene Q192R polymorphism and apolipoprotein B in Asian Indian women with coronary artery disease risk. | Genetic testing and molecular biomarkers | More Details |
| 23053877 | Association of PON1 and PON2 polymorphisms with PON1 activity and significant coronary stenosis in a Tunisian population. | Biochemical genetics | More Details |
| 23625196 | The Q192R polymorphism of the paraoxonase 1 gene is a risk factor for coronary artery disease in Saudi subjects. | Molecular and cellular biochemistry | More Details |
| 23608957 | Association of PON1 genotype and haplotype with susceptibility to coronary artery disease and clinical outcomes in dual antiplatelet-treated Han Chinese patients. | European journal of clinical pharmacology | More Details |
| 22669508 | "Paraoxonase 1, atherosclerosis and arterial stiffness in renal patients." | International urology and nephrology | More Details |
| 23391848 | "OLR1, PON1 and MTHFR gene polymorphisms, conventional risk factors and the severity of coronary atherosclerosis in a Chinese Han population." | Cellular physiology and biochemistry : international journal of experimental | More Details |
| 23382833 | Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease. | PloS one | More Details |
| 23418418 | Paraoxonase 1 gene polymorphism does not affect clopidogrel response variability but is associated with clinical outcome after PCI. | PloS one | More Details |
| 24167353 | Reduced paraoxonase 1 activity as a marker for severe coronary artery disease. | Disease markers | More Details |
| 22901080 | Ultrasensitive assay for detection of serum paraoxonase by modulating the growth of fluorescent semiconductor nanoparticles. | Analytical chemistry | More Details |
| 22750797 | Two- and three-locus haplotypes of the paraoxonase (PON1) gene are associated with coronary artery disease in Asian Indians. | Gene | More Details |
| 22402736 | Diet-induced weight loss in overweight or obese women and changes in high-density lipoprotein levels and function. | "Obesity (Silver Spring, Md.)" | More Details |
| 22643843 | Paraoxonase 1 and homocysteine metabolism. | Amino acids | More Details |
| 23181222 | Antioxidant and anti-inflammatory role of paraoxonase 1: implication in arteriosclerosis diseases. | North American journal of medical sciences | More Details |
| 22388798 | Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study. | Pharmacogenetics and genomics | More Details |
| 21867409 | The human paraoxonase gene cluster as a target in the treatment of atherosclerosis. | Antioxidants & redox signaling | More Details |
| 21681430 | Synergism between paraoxonase Arg 192 and the angiotensin converting enzyme D allele is associated with severity of coronary artery disease. | Molecular biology reports | More Details |
| 22320866 | Quantitative assessment of the influence of paraoxonase 1 activity and coronary heart disease risk. | DNA and cell biology | More Details |
| 22030099 | Association between PON1 activity and coronary heart disease risk: a meta-analysis based on 43 studies. | Molecular genetics and metabolism | More Details |
| 22333293 | Low serum PON1 activity: an independent risk factor for coronary artery disease in North-West Indian type 2 diabetics. | Gene | More Details |
| 22621394 | Evaluation of the future atherosclerotic heart disease with oxidative stress and carotid artery intima media thickness in gestational diabetes mellitus. | Endocrine research | More Details |
| 22723959 | Paraoxonase-1 is not a major determinant of stent thrombosis in a Taiwanese population. | PloS one | More Details |
| 22427735 | Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response. | Clinical pharmacology : advances and applications | More Details |
| 21960992 | Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery disease. | Experimental diabetes research | More Details |
| 22846213 | Paraoxonase-1 is not associated with coronary artery calcification in type 2 diabetes: results from the PREDICT study. | Disease markers | More Details |
| 22548179 | Regulation of hepatic paraoxonase-1 expression. | Journal of lipids | More Details |
| 21567207 | Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease. | Molecular and cellular biochemistry | More Details |
| 22123566 | [Paraoxonase-1 (PON1) activity in patients with coronary artery diseases and in diabetic patients]. | Annales de biologie clinique | More Details |
| 21748243 | "Plasma paraoxonase-1, oxidized low-density lipoprotein and lipid peroxidation levels in gout patients." | Cell biochemistry and biophysics | More Details |
| 21982484 | Interaction of folate intake and the paraoxonase Q192R polymorphism with risk of incident coronary heart disease and ischemic stroke: the atherosclerosis risk in communities study. | Annals of epidemiology | More Details |
| 21465165 | Paraoxonase Arg 192 allele is an independent risk factor for three-vessel stenosis of coronary artery disease. | Molecular biology reports | More Details |
| 21231776 | C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging. | Scandinavian journal of clinical and laboratory investigation | More Details |
| 22109721 | Frequency distribution of the single-nucleotide -108C/T polymorphism at the promoter region of the PON1 gene in Asian Indians and its relationship with coronary artery disease. | Journal of community genetics | More Details |
| 21287574 | "First survey of the three gene polymorphisms (PON1 Q192R, eNOS E298D and eNOS C-786T) potentially associated with coronary artery spasm in African populations and comparison with worldwide data." | Cell biochemistry and function | More Details |
| 21438666 | Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes. | Genetic testing and molecular biomarkers | More Details |
| 21527445 | No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting. | European heart journal | More Details |
| 21701074 | PON-dering differences in HDL function in coronary artery disease. | The Journal of clinical investigation | More Details |
| 21701070 | Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. | The Journal of clinical investigation | More Details |
| 21170047 | Paraoxonase-1 is a major determinant of clopidogrel efficacy. | Nature medicine | More Details |
| 20820904 | PON1 55 and 192 gene polymorphisms in type 2 diabetes mellitus patients in a Turkish population. | Biochemical genetics | More Details |
| 21146823 | Four genetic polymorphisms of paraoxonase gene and risk of coronary heart disease: a meta-analysis based on 88 case-control studies. | Atherosclerosis | More Details |
| 21450592 | "Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease." | European journal of cardiovascular prevention and rehabilitation : official | More Details |
| 21543280 | Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik. | Environmental health perspectives | More Details |
| 21620813 | Polymorphisms of pon1 and pon2 genes in hemodialyzed patients. | Clinical biochemistry | More Details |
| 21252261 | Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study. | Journal of lipid research | More Details |
| 21629682 | "Paraoxonase 1 (PON1) polymorphisms, haplotypes and activity in predicting cad risk in North-West Indian Punjabis." | PloS one | More Details |
| 21223581 | Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus. | BMC medical genetics | More Details |
| 22214423 | Effects of paraoxonase activity and gene polymorphism on coronary vasomotion. | EJNMMI research | More Details |
| 20856122 | Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis. | Genetics in medicine : official journal of the American College of Medical | More Details |
| 20012900 | Is alcohol beneficial or harmful for cardioprotection? | Genes & nutrition | More Details |
| 19939821 | The role of polymorphisms within paraoxonases (192 Gln/Arg in PON1 and 311Ser/Cys in PON2) in the modulation of cardiovascular risk: a pilot study. | Angiology | More Details |
| 20485444 | "Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population." | Journal of human genetics | More Details |
| 20026099 | The relationship between paraoxonase1-192 polymorphism and activity with coronary artery disease. | Clinical biochemistry | More Details |
| 20872564 | Matrix metalloproteinase-9 and paraoxonase 1 Q/R192 gene polymorphisms and the risk of coronary artery stenosis in Iranian subjects. | Journal of clinical laboratory analysis | More Details |
| 23105865 | Relationship between PON1L55M and Q192R gene polymorphisms and high APO B/APO A-I ratios. | Indian journal of clinical biochemistry : IJCB | More Details |
| 19219535 | "Association of genetic variants in Methylenetetrahydrofolate Reductase and Paraoxonase-1 genes with homocysteine, folate and vitamin B12 in coronary artery disease." | Molecular and cellular biochemistry | More Details |
| 19269283 | Association of homocysteine thiolactonase activity and PON1 polymorphisms with the severity of acute coronary syndrome. | Clinical biochemistry | More Details |
| 19843623 | Effect of preoperative atorvastatin therapy on paraoxonase activity and oxidative stress after coronary artery bypass grafting. | Perfusion | More Details |
| 19948975 | Integrative predictive model of coronary artery calcification in atherosclerosis. | Circulation | More Details |
| 19426787 | Molecular characterization and expression analysis of the porcine paraoxonase 3 (PON3) gene. | Gene | More Details |
| 19770524 | Paraoxonase 1 gene polymorphisms contribute to coronary artery disease risk among north Indians. | Indian journal of medical sciences | More Details |
| 19710913 | Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study. | PloS one | More Details |
| 19275503 | Novel serum paraoxonase activity assays are associated with coronary artery disease. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 18433845 | Paraoxonase 1 gene promoter polymorphisms are associated with the extent of stenosis in coronary arteries. | Thrombosis research | More Details |
| 18937674 | Glycation of paraoxonase-1 inhibits its activity and impairs the ability of high-density lipoprotein to metabolize membrane lipid hydroperoxides. | Diabetic medicine : a journal of the British Diabetic Association | More Details |
| 18634772 | PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients. | Clinical biochemistry | More Details |
| 18582459 | PON1Q192R polymorphism is associated with lipid profile in Mexican men with Mayan ascendancy. | Experimental and molecular pathology | More Details |
| 18349088 | Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. | JAMA : the journal of the American Medical Association | More Details |
| 17900266 | Genetic variation in the paraoxonase-3 (PON3) gene is associated with serum PON1 activity. | Annals of human genetics | More Details |
| 17683517 | The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics. | Annals of human genetics | More Details |
| 19005291 | The relationships between PON1 activity as well as oxLDL levels and coronary artery lesions in CHD patients with diabetes mellitus or impaired fasting glucose. | Coronary artery disease | More Details |
| 18430057 | Effect of statin therapy on plasma high-density lipoprotein-cholesterol levels is modified by paraoxonase 1 in Chinese patients with coronary heart disease. | Clinical and experimental pharmacology & physiology | More Details |
| 18164014 | Paraoxonase (PON1) and the risk for coronary heart disease and myocardial infarction in a general population of Dutch women. | Atherosclerosis | More Details |
| 18403458 | Effect of statins on serum apolipoprotein j and paraoxonase-1 levels in patients with ischemic heart disease undergoing coronary angiography. | Angiology | More Details |
| 18281420 | "Factors associated with paraoxonase genotypes and activity in a diverse, young, healthy population: the Coronary Artery Risk Development in Young Adults (CARDIA) study." | Clinical chemistry | More Details |
| 18601602 | High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 17525004 | PON1 activity is inversely related to LDL apoB carbonyl content in patients with coronary artery disease. | The Kaohsiung journal of medical sciences | More Details |
| 17560461 | Synergistic effects between Q192R polymorphism of paraoxonase 1 gene and some conventional risk factors in premature coronary artery disease. | Archives of medical research | More Details |
| 17587252 | PON1 activity and genotype in patients with arterial ischemic stroke and in healthy individuals. | Acta neurologica Scandinavica | More Details |
| 17185369 | Accuracy and biological variation of human serum paraoxonase 1 activity and polymorphism (Q192R) by kinetic enzyme assay. | Clinical chemistry | More Details |
| 17473052 | Exercise and diet induced weight loss improves measures of oxidative stress and insulin sensitivity in adults with characteristics of the metabolic syndrome. | American journal of physiology. Endocrinology and metabolism | More Details |
| 17437735 | Polymorphisms in the paraoxonase and endothelial nitric oxide synthase genes and the risk of early-onset myocardial infarction. | The American journal of cardiology | More Details |
| 17617030 | Paraoxonase 1 gene polymorphisms in angiographically assessed coronary artery disease: evidence for gender interaction among Brazilians. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 17065348 | Defective metabolism of oxidized phospholipid by HDL from people with type 2 diabetes. | Diabetes | More Details |
| 16185677 | Detecting the polymorphisms of paraoxonase (PON) cluster in Chinese Han population based on a rapid method. | Clinica chimica acta; international journal of clinical chemistry | More Details |
| 16423902 | Semiautomated method for determination of serum paraoxonase activity using paraoxon as substrate. | Clinical chemistry | More Details |
| 16327022 | Paraoxonase-1 and serum concentrations of HDL-cholesterol and apoA-I. | Journal of lipid research | More Details |
| 16781370 | Association of paraoxonase-1 activity and concentration with angiographic severity and extent of coronary artery disease. | Journal of the American College of Cardiology | More Details |
| 16140307 | High C-reactive protein and low paraoxonase1 in diabetes as risk factors for coronary heart disease. | Atherosclerosis | More Details |
| 16729301 | Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus. | Arthritis and rheumatism | More Details |
| 16940704 | Impact of paraoxonase polymorphism (Q192R) on endothelial function in intact coronary circulation. | Hypertension research : official journal of the Japanese Society of Hypertension | More Details |
| 16808888 | "Human serum paraoxonase gene polymorphisms, Q192R and L55M, are not associated with the risk of cerebral infarction in Chinese Han population." | Neurological research | More Details |
| 16319130 | Polymorphisms in the PON gene cluster are associated with Alzheimer disease. | Human molecular genetics | More Details |
| 16155079 | Decreased serum paraoxonase 1 (PON1) activity: an additional risk factor for atherosclerotic heart disease in patients with PCOS? | "Human reproduction (Oxford, England)" | More Details |
| 16875684 | "Hyperhomocysteinemia, paraoxonase activity and risk of coronary artery disease." | Clinical biochemistry | More Details |
| 17032132 | "Paraoxonase-1 (PON1) activity, but not PON1(Q192R) phenotype, is a predictor of coronary artery disease in a middle-aged Serbian population." | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 16239632 | Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke. | Stroke; a journal of cerebral circulation | More Details |
| 15928879 | Interaction between metabolic syndrome and PON1 polymorphisms as a determinant of the risk of coronary artery disease. | Clinical and experimental medicine | More Details |
| 15309416 | Paraoxonase activity in Greek migrants and Anglo-Celtic persons in the Melbourne Collaborative Cohort Study: relationship to dietary markers. | European journal of nutrition | More Details |
| 15654230 | "PON1 polymorphism, diabetes mellitus, obesity, and risk of myocardial infarction: Modifying effect of diabetes mellitus and obesity on the association between PON1 polymorphism and myocardial infarction." | Genetics in medicine : official journal of the American College of Medical | More Details |
| 16411410 | Endurance training reduces circulating asymmetric dimethylarginine and myeloperoxidase levels in persons at risk of coronary events. | Thrombosis and haemostasis | More Details |
| 15681296 | Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 15241482 | Paraoxonase 1 polymorphisms and survival. | European journal of human genetics : EJHG | More Details |
| 15454272 | Paraoxonase 1 and atherosclerosis: is the gene or the protein more important? | Free radical biology & medicine | More Details |
| 15265000 | Genetic and environmental factors modulating serum concentrations and activities of the antioxidant enzyme paraoxonase-1. | "Clinical science (London, England : 1979)" | More Details |
| 15089785 | "Smoking is associated with reduced serum levels of the antioxidant enzyme, paraoxonase, in Type 2 diabetic patients." | Diabetic medicine : a journal of the British Diabetic Association | More Details |
| 15087255 | The paraoxonase promoter polymorphism (-107)T>C is not associated with carotid intima-media thickness in Sicilian hypercholesterolemic patients. | Clinical biochemistry | More Details |
| 15135268 | Genetic risk for restenosis after coronary balloon angioplasty. | Atherosclerosis | More Details |
| 14996478 | PON1 M/L55 mutation protects high-risk patients against coronary artery disease. | International journal of cardiology | More Details |
| 15214960 | The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis. | BMC genetics | More Details |
| 15158307 | "Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation." | "Clinical nutrition (Edinburgh, Scotland)" | More Details |
| 15001326 | Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies. | Lancet | More Details |
| 15050299 | Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis. | Experimental gerontology | More Details |
| 14500290 | Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 12756158 | Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study. | Circulation | More Details |
| 12454802 | "Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study." | American journal of human genetics | More Details |
| 14551701 | "Paraoxonase gene polymorphisms, oxidative stress, and diseases." | "Journal of molecular medicine (Berlin, Germany)" | More Details |
| 12525679 | "Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism." | Annual review of medicine | More Details |
| 11810302 | Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm. | Human genetics | More Details |
| 12474066 | Paraoxonase 1 Q192R (PON1-192) polymorphism is associated with reduced lipid peroxidation in R-allele-carrier but not in QQ homozygous elderly subjects on a tomato-rich diet. | European journal of nutrition | More Details |
| 12417809 | Human paraoxonase 1 gene polymorphisms and the risk of coronary heart disease: a community-based study. | Cardiology | More Details |
| 11803456 | Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias. | Molecular psychiatry | More Details |
| 11230170 | A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation. | Genome research | More Details |
| 11409295 | Paraoxonase 1 192 Gln/Arg gene polymorphism and cerebrovascular disease: interaction with type 2 diabetes. | "Experimental and clinical endocrinology & diabetes : official journal, German" | More Details |
| 11096050 | Genetic polymorphism in paraoxonase is a risk factor for childhood focal segmental glomerulosclerosis. | American journal of kidney diseases : the official journal of the National Kidney | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 4 unique genes interacted with PON1. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| APOA1 | in vitro | 16128586 | CHD related |
| ALB | in vitro | 6324579 | CHD related |
| SUMO4 | Affinity Capture-MS | 16236267 | CHD related |
| CLU | Affinity Capture-Western | 8292612|8292612 | No |
There was no drug associated with PON1