How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: PROC

    Description: protein C (inactivator of coagulation factors Va and VIIIa)

    Entrez Gene ID: 5624

    SwissProt Acc Number: P04070

    RefSeq: NM_000312

    It was suspected to be CHD related:

    ..However in case of gene PROC C(-1654)T polymorphism we determined that patients with CAD diagnose and Talleles of PROC gene had unfavorable outcome more often than patients with homozygous C alleles...

    From PMID: 20873219, in Journal Mol Biol (Mosk). , 2010


    References

    There were 7 potential papers with PROC and CHD.

    PMIDTitleJournalsDetails
    21988946 The evolution of chest pain pathways.Critical pathways in cardiologyMore Details
    20545799 SAS macros for point and interval estimation of area under the receiver operating characteristic curve for non-proportional and proportional hazards Weibull models.Journal of evaluation in clinical practiceMore Details
    19802534 Effect of shenshao tablet on the quality of life for coronary heart disease patients with stable angina pectoris.Chinese journal of integrative medicineMore Details
    19629575 Completion angiography after cardiac surgery for congenital heart disease: complementing the intraoperative imaging modalities.Pediatric cardiologyMore Details
    18680534 "PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study."Journal of thrombosis and haemostasis : JTHMore Details
    18160056 The MRL mouse repairs both cryogenic and ischemic myocardial infarcts with scar.Cardiovascular pathology : the official journal of the Society for CardiovascularMore Details
    12820281 Evaluating medical diagnostic tests at the subunit level in the presence of verification bias.Statistics in medicineMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 14 unique genes interacted with PROC. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    PROCR Reconstituted Complex10681521 CHD related
    SERPINB6 in vitro7548163 No
    F5 in vitro1615482,7989361,10026263 CHD related
    PROC in vitro9003757 CHD related
    CP in vitro2105310 No
    PF4 Reconstituted Complex9395524 CHD related
    SERPINA5 Reconstituted Complex2551064|11123896 No
    CSNK2B Two-hybrid21900206 No
    TK1 Two-hybrid21900206 No
    PROS1 in vitro1615482,2461936 CHD related
    F2 in vitro2544585 CHD related
    THBD in vitro11106601,12588872 CHD related
    F8 in vitro;in vivo1939075,1761551 No
    GGCX in vitro1498334 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approved;nutraceuticalDB00170Menadione"The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification."B02BA02
    approvedDB00464Sodium Tetradecyl SulfateFor the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves.C05BB04