How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: PROCR

    Description: "protein C receptor, endothelial (EPCR)"

    Entrez Gene ID: 10544

    SwissProt Acc Number: Q9UNN8

    RefSeq: NM_006404

    It was supported literatures to be a novel CHD related gene:

    ..A common PROCR variant may be associated with decreased healthy survival in older adults. Additional studies are warranted to establish the role of PROCR variants in ischemic and aging-related disorders...

    From PMID: 18680534, in Journal J Thromb Haemost. , 2008


    References

    There were 2 potential papers with PROCR and CHD.

    PMIDTitleJournalsDetails
    23136988 Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study.BMC medical geneticsMore Details
    18680534 "PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study."Journal of thrombosis and haemostasis : JTHMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 7 unique genes interacted with PROCR. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    ATP6V1H Co-fractionation22939629 No
    EPB49 Two-hybrid16169070|16169070 No
    PROC Reconstituted Complex10681521 CHD related
    UBC Affinity Capture-MS21139048 No
    CTSB Co-fractionation22939629 CHD related
    SDHA Co-fractionation22939629 CHD related
    ABCB8 Co-fractionation22939629 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00055Drotrecogin alfaFor reduction of mortality in patients with severe sepsis.B01AD10
    experimentalDB04327Phosphatidylethanolamine