How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: PTH

    Description: parathyroid hormone

    Entrez Gene ID: 5741

    SwissProt Acc Number: P01270

    RefSeq: NM_000315

    It was supported literatures to be a novel CHD related gene:

    .."In uremia, PTH and phosphorus overload are both independently associated with major changes related to the cardiac remodeling process,emphasizing the need for a better control of these factors in chronic kidney disease."..

    From PMID: 21825304, in Journal Nephrol Dial Transplant. , 2012


    References

    There were 60 potential papers with PTH and CHD.

    PMIDTitleJournalsDetails
    23954837 Association of alkaline phosphatase with acute myocardial infarction in a population with high prevalence of hypovitaminosis D.Clinica chimica acta; international journal of clinical chemistryMore Details
    23975212 Inverse correlation between vascular calcification and bone mineral density in human immunodeficiency virus-infected patients.Calcified tissue internationalMore Details
    24131677 C-reactive protein and carotid and femoral intima media thickness: predicting inflammation.Clinical nephrologyMore Details
    24238050 Prospective analysis of coronary calcium in patients on dialysis undergoing a near-total parathyroidectomy.SurgeryMore Details
    23943031 "Presentation, management, and outcomes of hyperparathyroidism in octogenarians and nonagenarians."Annals of surgical oncologyMore Details
    22594967 Relationship between vitamin D deficiency and nondipper hypertension."Clinical and experimental hypertension (New York, N.Y. : 1993)"More Details
    23129037 The relationship between vitamin D deficiency and thoracic aortic dilatation.VASA. Zeitschrift fur GefasskrankheitenMore Details
    22013101 Vitamin D inadequacy is associated with significant coronary artery stenosis in a community-based elderly cohort: the Korean Longitudinal Study on Health and Aging.The Journal of clinical endocrinology and metabolismMore Details
    22189665 Secondary hyperparathyroidism: benign bystander or culpable contributor to adverse health outcomes?Southern medical journalMore Details
    22821942 Coronary microvascular dysfunction induced by primary hyperparathyroidism is restored after parathyroidectomy.CirculationMore Details
    22130958 Association of serum calcitonin with coronary artery disease in individuals with and without chronic kidney disease.International urology and nephrologyMore Details
    21825304 Parathyroid hormone and phosphorus overload in uremia: impact on cardiovascular system."Nephrology, dialysis, transplantation : official publication of the European"More Details
    22278430 Potential effects of alendronate on fibroblast growth factor 23 levels and effective control of hypercalciuria in an adult with Jansen's metaphyseal chondrodysplasia.The Journal of clinical endocrinology and metabolismMore Details
    22333003 Clinical profiles and risk factors for outcomes in older patients with cervical and trochanteric hip fracture: similarities and differences.Journal of trauma management & outcomesMore Details
    22572568 Relationship of urine dopamine with phosphorus homeostasis in humans: the heart and soul study.American journal of nephrologyMore Details
    21570529 "Plasma fibroblast growth factor 23, parathyroid hormone, phosphorus, and risk of coronary heart disease."American heart journalMore Details
    21359960 Elevated FGF 23 and phosphorus are associated with coronary calcification in hemodialysis patients."Pediatric nephrology (Berlin, Germany)"More Details
    21586795 Serum parathyroid hormone and risk of adverse outcomes in patients with stable coronary heart disease.Heart (British Cardiac Society)More Details
    21835295 "Parathyroid hormone, vitamin D, renal dysfunction, and cardiovascular disease: dependent or independent risk factors?"American heart journalMore Details
    21148030 The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis."Nephrology, dialysis, transplantation : official publication of the European"More Details
    20689328 "Fibroblast growth factor 23 in hemodialysis patients: effects of phosphate binder, calcitriol and calcium concentration in the dialysate."Nephron. Clinical practiceMore Details
    20299338 Outcome predictability of serum alkaline phosphatase in men with pre-dialysis CKD."Nephrology, dialysis, transplantation : official publication of the European"More Details
    20576822 Fibroblast growth factor 23 and fetuin A are independent predictors for the coronary artery disease extent in mild chronic kidney disease.Clinical journal of the American Society of Nephrology : CJASNMore Details
    20228165 Cardiac structure and diastolic function in mild primary hyperparathyroidism.The Journal of clinical endocrinology and metabolismMore Details
    19763871 Statins and vitamin D: a friendly association in pre-dialysis patients.International urology and nephrologyMore Details
    20588059 Treatment of Hemodialysis-Associated Adynamic Bone Disease with Teriparatide (PTH(1-34)): A Pilot Study.Kidney & blood pressure researchMore Details
    20110249 Study design and subject baseline characteristics in the ADVANCE Study: effects of cinacalcet on vascular calcification in haemodialysis patients."Nephrology, dialysis, transplantation : official publication of the European"More Details
    20439261 Parathyroid hormone level is associated with mortality and cardiovascular events in patients undergoing coronary angiography.European heart journalMore Details
    20199875 Association of relatively low serum parathyroid hormone with malnutrition-inflammation complex and survival in maintenance hemodialysis patients.Journal of renal nutrition : the official journal of the Council on RenalMore Details
    20491972 Malnutrition-inflammation-coronary calcification in pediatric patients receiving chronic hemodialysis.Hemodialysis international. International Symposium on Home HemodialysisMore Details
    19850559 Pregnancy-associated plasma protein-A is an independent short-time predictor of mortality in patients on maintenance haemodialysis.European heart journalMore Details
    20043335 Irreversible end-stage heart failure in a young patient due to severe chronic hypocalcemia associated with primary hypoparathyroidism and celiac disease.Clinical cardiologyMore Details
    20821006 Reduced coronary flow reserve in patients with primary hyperparathyroidism: a study by G-SPECT myocardial perfusion imaging.European journal of nuclear medicine and molecular imagingMore Details
    20565936 Risk factors of one year increment of coronary calcifications and survival in hemodialysis patients.BMC nephrologyMore Details
    19661219 Clinical outcomes with active versus nutritional vitamin D compounds in chronic kidney disease.Clinical journal of the American Society of Nephrology : CJASNMore Details
    19667039 Progression of cardiac dysfunction in patients with atherosclerotic renovascular disease.QJM : monthly journal of the Association of PhysiciansMore Details
    19763373 Elevated serum PTH is independently associated with poor outcomes in older patients with hip fracture and vitamin D inadequacy.Calcified tissue internationalMore Details
    19368508 Consequences of a plant-based diet with low dairy consumption on intake of bone-relevant nutrients.Journal of women's health (2002)More Details
    19217213 "Poor vitamin D status may contribute to high risk for insulin resistance, obesity, and cardiovascular disease in Asian Indians."Medical hypothesesMore Details
    19574729 Endothelial function and endothelial nitric oxide synthase intron 4a/b polymorphism in primary hyperparathyroidism.Journal of endocrinological investigationMore Details
    19539290 "Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis."AtherosclerosisMore Details
    19287183 Statins do not affect mineral metabolism in chronic kidney disease: a retrospective analysis.Nephron. Clinical practiceMore Details
    18597636 Bone markers predict cardiovascular events in chronic kidney disease.Journal of bone and mineral research : the official journal of the AmericanMore Details
    18055578 Parathyroid hormone treatment after myocardial infarction promotes cardiac repair by enhanced neovascularization and cell survival.Cardiovascular researchMore Details
    17524408 Markers of vascular disease do not differ in black and white hemodialysis patients despite a different risk profile.AtherosclerosisMore Details
    18687772 Sevelamer restores bone volume and improves bone microarchitecture and strength in aged ovariectomized rats.EndocrinologyMore Details
    17597083 Are PTH serum levels predictive of coronary calcifications in haemodialysis patients?"Nephrology, dialysis, transplantation : official publication of the European"More Details
    17368185 Vitamin D analogs for secondary hyperparathyroidism: what does the future hold?The Journal of steroid biochemistry and molecular biologyMore Details
    17374704 "Alanine to serine polymorphism at position 986 of the calcium-sensing receptor associated with coronary heart disease, myocardial infarction, all-cause, and cardiovascular mortality."The Journal of clinical endocrinology and metabolismMore Details
    17036158 Impairment of flow mediated vasodilatation of brachial artery in patients with primary hyperparathyroidism.The international journal of cardiovascular imagingMore Details
    17410101 Vascular calcification: contribution of parathyroid hormone in renal failure.Kidney internationalMore Details
    17299676 [Diffuse pulmonary calcifications caused by hyperparathyroidism in a renal transplant recipient].Deutsche medizinische Wochenschrift (1946)More Details
    17368822 Calcium-regulating peptide hormones and blood electrolytic balance in chronic heart failure.Regulatory peptidesMore Details
    16600341 Vitamin D and disease prevention with special reference to cardiovascular disease.Progress in biophysics and molecular biologyMore Details
    16311258 Severe hyperparathyroidism with bone abnormalities and metastatic calcification in rats with adenine-induced uraemia."Nephrology, dialysis, transplantation : official publication of the European"More Details
    16884398 Vascular calcification and renal osteodystrophy relationship in chronic kidney disease.European journal of clinical investigationMore Details
    15613068 Subclinical peripheral arterial disease in patients with chronic kidney disease: prevalence and related risk factors.Kidney international. SupplementMore Details
    16103720 A high calcium-phosphate product is associated with high C-reactive protein concentrations in hemodialysis patients.Nephron. Clinical practiceMore Details
    15102961 Determinants of progressive vascular calcification in haemodialysis patients."Nephrology, dialysis, transplantation : official publication of the European"More Details
    12081584 Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients.Kidney internationalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 8 unique genes interacted with PTH. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    BAG6 Two-hybrid16169070 No
    FEZ1 Two-hybrid16169070|16169070 No
    PTH in vitro10837469 CHD related
    BAT3 yeast 2-hybrid16169070 CHD related
    MEP1A Biochemical Activity11278902|11278902 No
    PTH1R Reconstituted Complex9108031|9108031 No
    PTH2R Reconstituted Complex9482662|9482662 No
    KIAA1244 Affinity Capture-Western11551928 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    experimentalDB04419Norleucine