How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: REN

    Description: renin

    Entrez Gene ID: 5972

    SwissProt Acc Number: P00797

    RefSeq: NM_000537

    It was suspected to be CHD related:

    .."Moreover, there was a trend for the SL genotype of the REN gene toward increased risk for CAD."..

    From PMID: 20529973, in Journal Angiology. , 2010


    References

    There were 5 potential papers with REN and CHD.

    PMIDTitleJournalsDetails
    21609284 Associations of the SREBP-1c gene polymorphism with gender-specific changes in serum lipids induced by a high-carbohydrate diet in healthy Chinese youth."Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition "More Details
    20529973 Polymorphisms of renin-angiotensin system and natriuretic peptide receptor A genes in patients of Greek origin with a history of myocardial infarction.AngiologyMore Details
    16151023 Novel role of lactosylceramide in vascular endothelial growth factor-mediated angiogenesis in human endothelial cells.Circulation researchMore Details
    16291512 Functional characteristics of coronary vasomotor function following intramyocardial gene therapy with naked DNA encoding for vascular endothelial growth factor165.Endothelium : journal of endothelial cell researchMore Details
    15135705 Comparison of treatment outcomes in patients > or =80 years undergoing transradial versus transfemoral coronary intervention.The American journal of cardiologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 7 unique genes interacted with REN. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    M6PR in vitro2960682 No
    KCTD15 Two-hybrid16169070 No
    ATP6AP2 Reconstituted Complex12045255|12045255 No
    RENBP in vitro11098137 No
    PCSK5 in vitro8901832 CHD related
    CTSB in vitro;in vivo1597471,2061332,3542996,9928950 CHD related
    PCSK1 in vitro;in vivo1597471,2061332,3542996 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00212RemikirenFor the treatment of hypertension and heart failureC09XA01
    approvedDB01258AliskirenFor the treatment of mild to moderate hypertension. It may be used alone or in combination with other antihypertensive agents.C09XA02
    experimentalDB01844Dimethylformamide
    experimentalDB022961-Hydroxy-3-Methylbutane
    experimentalDB02803"3-Phenyl-1,2-Propandiol"
    experimentalDB030242-Methyl-3-(2-Aminothiazolo)Propanal
    experimentalDB03395Enalkiren
    experimentalDB037362-Cyclopropylmethylenepropanal
    experimentalDB03968"1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine"
    experimentalDB04379N-Methyl-N-(Methylbenzyl)Formamide
    experimentalDB043871-Hydroxy-2-Amino-3-Cyclohexylpropane
    experimentalDB06899"N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDE"
    experimentalDB06967"6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINE"
    experimentalDB07059"N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE"
    experimentalDB07113"(2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE"
    experimentalDB07174"6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE"
    experimentalDB07244"5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE"
    experimentalDB08099"6-ETHYL-5-[(2S)-1-(3-METHOXYPROPYL)-2-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-7-YL]PYRIMIDINE-2,4-DIAMINE"