How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: RLS

    Description: "Restless legs syndrome, susceptibility to"

    Entrez Gene ID: 192142

    SwissProt Acc Number:


    It was supported literatures to be a novel CHD related gene:

    ..Previous cross-sectional studies suggested a positive association between restless legs syndrome (RLS) and coronary heart disease (CHD)..

    From PMID: 22967852, in Journal Circulation. , 2012


    There were 8 potential papers with RLS and CHD.

    24186963 Myocardial Strain Analysis by 2-dimensional Speckle Tracking Echocardiography Improves Diagnostics of Coronary Artery Stenosis in Stable Angina Pectoris.Circulation. Cardiovascular imagingMore Details
    22967852 Prospective study of restless legs syndrome and coronary heart disease among women.CirculationMore Details
    22447047 Restless legs syndrome and risk of incident cardiovascular disease in women and men: prospective cohort study.BMJ openMore Details
    21174071 [Restless legs syndrome and cardiovascular risk].Der NervenarztMore Details
    19951275 Prevalence and associated factors of restless legs in a 57-year-old urban population in northern Finland.Acta neurologica ScandinavicaMore Details
    18166705 Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study.NeurologyMore Details
    17105517 Medication tolerance and augmentation in restless legs syndrome: the need for drug class rotation.Journal of general internal medicineMore Details
    15372599 Impact of regular LDL apheresis on the development of restless legs syndrome.Movement disorders : official journal of the Movement Disorder SocietyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There was NO PPI interaction information about RLS

    Involved FDA drugs

    There was no drug associated with RLS