How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: S100A12

    Description: S100 calcium binding protein A12

    Entrez Gene ID: 6283

    SwissProt Acc Number: P80511

    RefSeq: NM_005621

    It was supported literatures to be a novel CHD related gene:

    .."The S100A12 expression on the CECs surface increased significantly in patients with KD and persisted for a longer time in patients with CALs, suggesting that the S100A12 expression on CECs may be involved in the development of CALs (coronary artery lesions)."..

    From PMID: 20461025, in Journal Pediatr Res. , 2010


    References

    There were 8 potential papers with S100A12 and CHD.

    PMIDTitleJournalsDetails
    23609464 Serum S100A12 levels are correlated with the presence and severity of coronary artery disease in patients with type 2 diabetes mellitus.Journal of investigative medicine : the official publication of the AmericanMore Details
    23171632 Reverse regulation of soluble receptor for advanced glycation end products and proinflammatory factor resistin and S100A12 in Kawasaki disease.Arthritis research & therapyMore Details
    22248048 "Large molecular size EDTA-resistant complexes containing S100A12, ERAC, in serum during inflammatory conditions."Scandinavian journal of clinical and laboratory investigationMore Details
    20966394 S100A12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein E-null mice by activating an osteogenic gene regulatory program."Arteriosclerosis, thrombosis, and vascular biology"More Details
    20461025 S100A12 on circulating endothelial cells surface in children with Kawasaki disease.Pediatric researchMore Details
    19680167 Clinical score and transcript abundance patterns identify Kawasaki disease patients who may benefit from addition of methylprednisolone.Pediatric researchMore Details
    19430379 Infliximab reduces the cytokine-mediated inflammation but does not suppress cellular infiltration of the vessel wall in refractory Kawasaki disease.Pediatric researchMore Details
    19542470 Pleiotropic roles of S100A12 in coronary atherosclerotic plaque formation and rupture."Journal of immunology (Baltimore, Md. : 1950)"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 3 unique genes interacted with S100A12. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    S100A12 Co-crystal Structure11134923|10666601,11134923,11856825,12777802 CHD related
    AGER in vitro;in vivo10399917 CHD related
    CACYBP in vivo12042313 CHD related


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00768OlopatadineFor the treatment of ocular itching associated with allergic conjunctivitis.S01GX09;R01AC08
    approvedDB01025AmlexanoxUsed as a paste in the mouth to treat aphthous ulcers (canker sores). A01AD07;R03DX01