How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: SELE

    Description: selectin E

    Entrez Gene ID: 6401

    SwissProt Acc Number: P16581

    RefSeq: NM_000450

    It was suspected to be CHD related:

    .."it was found an association between young AMI and polymorphism C-260T in the CD14 gene, between coronarics atherosclerosis and polymorphism A516C in the E Selectin gene or polymorphisms Leu125Val and Ser563Asn in the PECAM1 gene."..

    From PMID: 15284679, in Journal Minerva Cardioangiol , 2004


    References

    There were 7 potential papers with SELE and CHD.

    PMIDTitleJournalsDetails
    24260191 Association of A561C and G98T Polymorphisms in E-Selectin Gene with Coronary Artery Disease: A Meta-Analysis.PloS oneMore Details
    22388798 Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.Pharmacogenetics and genomicsMore Details
    22414298 Lack of an association between E-selectin gene polymorphisms and risk of Kawasaki disease.Pediatrics international : official journal of the Japan Pediatric SocietyMore Details
    21827804 Effect of the E-selectin gene polymorphism (S149R) on platelet activation and adverse events after coronary artery surgery.Archives of medical researchMore Details
    17236131 Multiple genes for essential-hypertension susceptibility on chromosome 1q.American journal of human geneticsMore Details
    17020471 Different genes and polymorphisms affecting high-density lipoprotein cholesterol levels in Greek familial hypercholesterolemia patients.Genetic testingMore Details
    14557872 Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients.Human geneticsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 13 unique genes interacted with SELE. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    PTK2 Affinity Capture-Western8609175 No
    TLN1 Affinity Capture-Western8609175 No
    PXN Affinity Capture-Western8609175 No
    ACTN2 in vitro8609175 No
    CD44 in vitro;in vivo11402070 CHD related
    SERPING1 Affinity Capture-Western14568956|14568956 No
    PLCG1 Affinity Capture-Western12960351|12960351 CHD related
    PTPN11 Affinity Capture-Western11602579|11602579 CHD related
    GLG1 Reconstituted Complex11404363|11404363 No
    SELL Affinity Capture-Luminescence9024699|9024699 CHD related
    VCL in vitro8609175 CHD related
    FLNA in vitro8609175 No
    SELPLG in vitro;in vivo8621728,9128259 CHD related


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    experimentalDB03721O-Sialic Acid