How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: SELP

    Description: "selectin P (granule membrane protein 140kDa, antigen CD62)"

    Entrez Gene ID: 6403

    SwissProt Acc Number: P16109

    RefSeq: NM_003005

    It was suspected to be CHD related:

    .."Eight genes, namely MMP2, PTGS2, PECAM1, SELP, SELL, CYP1A1, MMRN1, and HSPA1A, were involved in atherosclerosis and myocardial infarction."..

    From PMID: 22126760, in Journal Nan Fang Yi Ke Da Xue Xue Bao , 2011


    References

    There were 9 potential papers with SELP and CHD.

    PMIDTitleJournalsDetails
    24267260 Quantitative and qualitative pleiotropic differences between Simvastatin single and Vytorin combination therapy in hypercholesterolemic subjects.AtherosclerosisMore Details
    22717531 Individual and summed effects of high-risk genetic polymorphisms on recurrent cardiovascular events following ischemic heart disease.AtherosclerosisMore Details
    20376705 Contribution of SELP and PSGL-1 genotypes and haplotypes to the presence of coronary heart disease in Tunisians.Molecular biology reportsMore Details
    19948214 Detection of a large deletion in the P-selectin (SELP) gene.Molecular and cellular probesMore Details
    20855565 Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.Journal of lipid researchMore Details
    19590054 P-selectin 1087G/A polymorphism is associated with neuropsychological test performance in older adults with cardiovascular disease.Stroke; a journal of cerebral circulationMore Details
    18535285 "Soluble P-selectin, SELP polymorphisms, and atherosclerotic risk in European-American and African-African young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.""Arteriosclerosis, thrombosis, and vascular biology"More Details
    17498578 Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery.Journal of the American College of CardiologyMore Details
    14557872 Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients.Human geneticsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 10 unique genes interacted with SELP. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    AP1M1 Co-crystal Structure11247301|11247301 No
    VCAN Reconstituted Complex10950950|10950950 CHD related
    SELP in vitro11081633 CHD related
    FUT4 in vitro7508745 No
    SNX17 Two-hybrid11237770|11237770 No
    SERPING1 Affinity Capture-Western14568956|14568956 No
    CD24 Reconstituted Complex9129046|9129046 No
    GP1BA Reconstituted Complex10499919|10499919 CHD related
    SELPLG Affinity Capture-Western10713099|9128259,10713099,17064811 CHD related
    EZR Reconstituted Complex10733515 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB01109Heparin"Unfractionated heparin is indicated for prophylaxis and treatment of venous thrombosis and its extension, prevention of post-operative deep venous thrombosis and pulmonary embolism and prevention of clotting in arterial and cardiac surgery. In cardiology, it is used to prevent embolisms in patients with atrial fibrillation and as an adjunct antithrombin therapy in patients with unstable angina and/or non-Q wave myocardial infarctions (i.e. non-ST elevated acute coronary artery syndrome) who are on platelet glycoprotein (IIb/IIIa) receptor inhibitors. Additionally, it is used to prevent clotting during dialysis and surgical procedures, maintain the patency of intravenous injection devices and prevent in vitro coagulation of blood transfusions and in blood samples drawn for laboratory values."B01AB01;C05BA01;C05BA03;S01XA09;S01XA14;B01AB05
    experimentalDB03721O-Sialic Acid
    approvedDB06779DalteparinB01AB04
    approvedDB08813Nadroparin"Nadroparin is used for prophylaxis of thromboembolic disorders and general surgery in orthopedic surgery, treatment of deep vein thrombosis, prevention of clotting during hemodialysis and treatment of unstable angina and non-Q wave myocardial infarction"B01AB06