How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: SFTPD

    Description: surfactant protein D

    Entrez Gene ID: 6441

    SwissProt Acc Number: P35247

    RefSeq: NM_003019

    It was supported literatures to be a novel CHD related gene:

    .."There was a significant linear association between the number of high-risk gene variants (IL6-174CC, SFTPD 11CC and TLR4 299AA) and the proportion of patients with coronary artery disease (P < 0.0005)."..

    From PMID: 19140875, in Journal Scand J Immunol. , 2009


    There were 1 potential papers with SFTPD and CHD.

    19140875 The additive contribution from inflammatory genetic markers on the severity of cardiovascular disease.Scandinavian journal of immunologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 5 unique genes interacted with SFTPD. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    DCN Reconstituted Complex12730206|12730206 CHD related
    MFAP4 Reconstituted Complex10542261 No
    SFTPD in vitro10368295,12888356 CHD related
    SFTPA1 Co-purification10101009 No
    DMBT1 Co-purification10101009|10101009|9153228|9153228 No

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code