How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: SIRT1

    Description: sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)

    Entrez Gene ID: 23411

    SwissProt Acc Number: Q96EB6

    RefSeq: NM_001142498

    It was suspected to be CHD related:

    .."Inhibition of SIRT1, either directly or by restricting the availability of its substrate NAD(+), inhibits IPC( Acute ischaemic preconditioning ). "..

    From PMID: 20823277, in Journal Cardiovasc Res. , 2011


    References

    There were 18 potential papers with SIRT1 and CHD.

    PMIDTitleJournalsDetails
    23932046 An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy.International journal of cardiologyMore Details
    24219792 The endotoxin/toll-like receptor-4 axis mediates gut microvascular dysfunction associated with post-prandial lipidemia.BMC physiologyMore Details
    23305113 The combined effects of genetic variation in the SIRT1 gene and dietary intake of n-3 and n-6 polyunsaturated fatty acids on serum LDL-C and HDL-C levels: a population based study.Lipids in health and diseaseMore Details
    23382833 Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease.PloS oneMore Details
    22935421 Genetic analysis of the SIRT1 gene promoter in myocardial infarction.Biochemical and biophysical research communicationsMore Details
    22200427 SIRTUIN 1 gene polymorphisms are associated with cholesterol metabolism and coronary artery calcification in Japanese hemodialysis patients.Journal of renal nutrition : the official journal of the Council on RenalMore Details
    22185448 Targeting cardiovascular disease with novel SIRT1 pathways.Future cardiologyMore Details
    22364258 MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression."Clinical science (London, England : 1979)"More Details
    20823277 Lysine deacetylation in ischaemic preconditioning: the role of SIRT1.Cardiovascular researchMore Details
    20431281 Anti-aging medicine: molecular basis for endothelial cell-targeted strategies - a mini-review.GerontologyMore Details
    19786632 MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1.CirculationMore Details
    19429820 Resveratrol induces mitochondrial biogenesis in endothelial cells.American journal of physiology. Heart and circulatory physiologyMore Details
    19059213 Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway.Biochemical and biophysical research communicationsMore Details
    19549533 Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.Mechanisms of ageing and developmentMore Details
    18826227 Akt/FOXO3a/SIRT1-mediated cardioprotection by n-tyrosol against ischemic stress in rat in vivo model of myocardial infarction: switching gears toward survival and longevity.Journal of agricultural and food chemistryMore Details
    18389338 Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis.Heart and vesselsMore Details
    18208353 Sirt1 protects the heart from aging and stress.Biological chemistryMore Details
    18192848 Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat.Journal of hypertensionMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 224 unique genes interacted with SIRT1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    SUV39H1 Affinity Capture-Western19218236 No
    KAT2B Biochemical Activity19188449|19188449 No
    E2F1 Affinity Capture-Western19188449 CHD related
    MEF2C Co-localization19553684 No
    MYOD1 Co-localization19553684 No
    RELA Affinity Capture-Western17041012|15152190 CHD related
    CTTN Affinity Capture-Western18850005|18850005|18850005 No
    NEDD8 Affinity Capture-Western16998474 No
    AR Affinity Capture-Western16923962|16923962|16923962|22318606 CHD related
    NCOR1 Reconstituted Complex18829436|18829436 No
    JUN Affinity Capture-Western18823944|20042607|20042607 CHD related
    DOT1L Affinity Capture-Western19491102 No
    CLOCK Affinity Capture-Western18662547|18662547|22318606 No
    ARNTL Affinity Capture-Western18662547|18662547 No
    HDAC4 Affinity Capture-Western16166628 CHD related
    tat Biochemical Activity15719057|15719057 No
    SUZ12 Affinity Capture-Western15684044 No
    DBC1 Affinity Capture-Western18235502|18235502|21030595 No
    TP53 Affinity Capture-Western18235502|21245319|22318606|12006491|12006491|11672523 CHD related
    SIRT2 Affinity Capture-Western18193082|22318606 No
    RBP1 Affinity Capture-Western18193082 No
    ARID4B Affinity Capture-Western18193082 No
    ING2 Affinity Capture-Western18193082|22318606 No
    ING1 Affinity Capture-Western18193082|22318606 No
    BHLHE41 Reconstituted Complex17487425 No
    TLE1 Two-hybrid17680780|17680780 No
    NBN Affinity Capture-Western17612497|17612497|17612497 No
    DVL1 Affinity Capture-Western20439735 CHD related
    DVL2 Affinity Capture-Western20439735 CHD related
    CSNK2A1 Affinity Capture-Western20439735 CHD related
    SMAD7 Affinity Capture-Western17098745|17098745 No
    NR1H4 Reconstituted Complex19883617|19883617 No
    SREBF1 Biochemical Activity20595232 No
    HNF1A Reconstituted Complex21176092|21176092 CHD related
    GAPDH Affinity Capture-Western20972425|20972425 No
    ACACA Affinity Capture-Western19343720|19343720 CHD related
    HSPA4 Affinity Capture-Western19343720 No
    WRN Affinity Capture-Western19343720|19343720 CHD related
    HSPD1 Affinity Capture-MS19343720 CHD related
    CHCHD2 Affinity Capture-MS19343720 No
    DIAPH3 Affinity Capture-MS19343720 No
    YBX1 Affinity Capture-MS19343720 CHD related
    DYNC1H1 Affinity Capture-MS19343720 No
    HSPA1L Affinity Capture-MS19343720 No
    HSPA5 Affinity Capture-MS19343720 No
    HIST1H2BC Affinity Capture-MS19343720 No
    HIST2H2AB Affinity Capture-MS19343720 No
    HSPA9 Affinity Capture-MS19343720 No
    HDAC2 Affinity Capture-MS19343720 CHD related
    CMYA5 Affinity Capture-MS19343720 No
    KPNA2 Affinity Capture-MS19343720 No
    KPNA3 Affinity Capture-MS19343720 No
    LAMA3 Affinity Capture-MS19343720 CHD related
    EEF1G Affinity Capture-MS19343720 No
    ARHGAP29 Affinity Capture-MS19343720 No
    MCF2L2 Affinity Capture-MS19343720 No
    ELL3 Affinity Capture-MS19343720 No
    USP9Y Affinity Capture-MS19343720 No
    NAT10 Affinity Capture-MS19343720 No
    UGDH Affinity Capture-MS19343720 No
    CACNA1C Affinity Capture-MS19343720 CHD related
    LANCL1 Affinity Capture-MS19343720 No
    ZEB1 Affinity Capture-Western22249256 No
    MECOM Affinity Capture-Western21555002 No
    KAT8 Affinity Capture-Western21502975|21502975|21502975|22318606 No
    CSNK2B Affinity Capture-Western21968188 No
    DNMT1 Biochemical Activity21947282|21947282 No
    ESR1 Affinity Capture-Western21920899 CHD related
    STAT3 Affinity Capture-Western22542455 CHD related
    JAK1 Affinity Capture-Western22542455 CHD related
    HSP90AA1 Affinity Capture-Western22542455|22318606 CHD related
    TRIM28 Affinity Capture-Western22542455 No
    KAT2A Affinity Capture-Western22542455 No
    HNRNPK Affinity Capture-Western22542455 No
    SATB1 Affinity Capture-Western22328728|22328728|22328728 No
    FKBP1A Biochemical Activity22318606|22318606 CHD related
    PCNA Biochemical Activity22318606|22318606 CHD related
    MAP2K4 Biochemical Activity22318606|22318606 No
    DGKA Biochemical Activity22318606|22318606 No
    SET Biochemical Activity22318606|22318606 No
    PSMA2 Biochemical Activity22318606|22318606 No
    PSMA4 Biochemical Activity22318606|22318606 No
    PSMA7 Biochemical Activity22318606|22318606 No
    ALG8 Negative Genetic22318606 No
    ANAPC13 Negative Genetic22318606 No
    AURKB Negative Genetic22318606 No
    BCCIP Negative Genetic22318606 No
    BCL11B Negative Genetic22318606 No
    BRCA1 Negative Genetic22318606 CHD related
    BRCA2 Negative Genetic22318606 No
    C9orf156 Negative Genetic22318606 No
    CAD Negative Genetic22318606 No
    CDC20 Negative Genetic22318606 No
    CDC42BPA Negative Genetic22318606 No
    CDC7 Negative Genetic22318606 No
    CGN Negative Genetic22318606 No
    CHEK1 Negative Genetic22318606 No
    CHFR Negative Genetic22318606 No
    COASY Negative Genetic22318606 No
    CRY1 Negative Genetic22318606 No
    CRY2 Negative Genetic22318606 No
    CSE1L Negative Genetic22318606 No
    CSNK1D Negative Genetic22318606 No
    CSNK1E Negative Genetic22318606 No
    DCLRE1A Negative Genetic22318606 No
    DCLRE1B Negative Genetic22318606 No
    DNAJB12 Negative Genetic22318606 No
    DNAJC7 Negative Genetic22318606 No
    EIF2C2 Negative Genetic22318606 No
    ELAVL3 Negative Genetic22318606 No
    FBXL17 Negative Genetic22318606 No
    FIG4 Negative Genetic22318606 No
    GADD45A Negative Genetic22318606 No
    GATAD1 Negative Genetic22318606 No
    GFPT1 Negative Genetic22318606 No
    GFPT2 Negative Genetic22318606 No
    HDAC11 Negative Genetic22318606 No
    HLF Negative Genetic22318606 No
    HRAS Negative Genetic22318606 No
    IKZF5 Negative Genetic22318606 No
    ING3 Negative Genetic22318606 No
    KIT Negative Genetic22318606 No
    KITLG Negative Genetic22318606 No
    KRAS Negative Genetic22318606 No
    LMX1A Negative Genetic22318606 No
    MAP3K11 Negative Genetic22318606 No
    MYCBP2 Negative Genetic22318606 No
    NFKB2 Negative Genetic22318606 No
    NR1D2 Negative Genetic22318606 No
    NXF1 Negative Genetic22318606 No
    PARP6 Negative Genetic22318606 No
    PER1 Negative Genetic22318606 No
    PER3 Negative Genetic22318606 No
    PI4KA Negative Genetic22318606 No
    PKIB Negative Genetic22318606 No
    PLK1 Negative Genetic22318606 No
    POLR2E Negative Genetic22318606 No
    POLR2G Negative Genetic22318606 No
    PPP1R7 Negative Genetic22318606 No
    PSMA5 Negative Genetic22318606 No
    PSMD1 Negative Genetic22318606 No
    RANBP2 Negative Genetic22318606 No
    RB1 Negative Genetic22318606 CHD related
    RFC5 Negative Genetic22318606 No
    RORB Negative Genetic22318606 No
    RPA3 Negative Genetic22318606 No
    RPS10 Negative Genetic22318606 No
    SF3A1 Negative Genetic22318606 No
    SF3B1 Negative Genetic22318606 No
    SRSF2 Negative Genetic22318606 No
    SLC18A1 Negative Genetic22318606 No
    SLC7A3 Negative Genetic22318606 No
    TP53BP2 Negative Genetic22318606 No
    TRIM34 Negative Genetic22318606 No
    UBXN2A Negative Genetic22318606 No
    UCP2 Negative Genetic22318606 CHD related
    ZDHHC15 Negative Genetic22318606 No
    CAPNS1 Positive Genetic22318606 No
    CD1A Positive Genetic22318606 No
    CDK19 Positive Genetic22318606 No
    CS Positive Genetic22318606 No
    DGUOK Positive Genetic22318606 No
    EP300 Positive Genetic22318606|15632193 CHD related
    ERBB2IP Positive Genetic22318606 No
    FASLG Positive Genetic22318606 No
    HPRT1 Positive Genetic22318606 No
    CDHR2 Positive Genetic22318606 No
    PRNP Positive Genetic22318606 No
    RIC8A Positive Genetic22318606 No
    SAP30 Positive Genetic22318606 No
    SNAPC1 Positive Genetic22318606 No
    TM4SF4 Positive Genetic22318606 No
    WNK4 Positive Genetic22318606 No
    ZMYM5 Positive Genetic22318606 No
    MYCN Affinity Capture-Western21698133 No
    FOS Reconstituted Complex20042607|20042607 CHD related
    GTF2A1 Co-fractionation22939629 No
    SMARCD2 Co-fractionation22939629 No
    HIST1H1B in vitro15469825 No
    HES1 Affinity Capture-Western12535671|12535671 No
    HEY2 Affinity Capture-Western12535671 CHD related
    NR1H3 Affinity Capture-Western17936707 CHD related
    NR1H2 Affinity Capture-Western17936707 CHD related
    USP22 Affinity Capture-MS19615732|22542455 No
    KAT5 Affinity Capture-Western20100829|19895790|22586264 No
    MAPK8 Affinity Capture-Western20027304|20027304 CHD related
    ZBTB7A Affinity Capture-Western19244234 No
    HSF1 Affinity Capture-Western19229036 CHD related
    NUDT21 Affinity Capture-Western17172643 No
    PAPOLA Affinity Capture-Western17172643 No
    PPARGC1A Co-localization19553684|15744310 CHD related
    AKIP1 Affinity Capture-Western16998474 No
    FOXO1 Affinity Capture-Western16154098|22013015|15692560 CHD related
    RRP8 Affinity Capture-Western18485871|18485871 No
    EZH2 Affinity Capture-Western15684044 No
    BCL11A Affinity Capture-Western15639232 No
    FOXO4 Affinity Capture-Western15126506 No
    FOXO3 Affinity Capture-Western15126506|20733005|14976264 CHD related
    ESRRA Reconstituted Complex20484414 No
    HIC1 Affinity Capture-Western17283066|22510409|16269335|16269335 No
    CTNNB1 Affinity Capture-Western20439735 CHD related
    MLLT3 Affinity Capture-MS20431927 No
    MLLT1 Affinity Capture-MS20431927 No
    NPM1 Affinity Capture-MS20431927 No
    NR0B2 Reconstituted Complex20375098|20375098 No
    HNF4A Affinity Capture-Western20375098|15744310 No
    SETD7 Affinity Capture-Western21245319 No
    STK4 Biochemical Activity21212262 No
    MAPT Reconstituted Complex20869593|20869593 No
    VDR Affinity Capture-Western20733005|20733005 CHD related
    SKI Affinity Capture-Western21149449 No
    Cdca8 Affinity Capture-MS20360068 No
    ATG7 Affinity Capture-Western18296641 No
    ATG5 Affinity Capture-Western18296641 No
    GABARAPL1 Affinity Capture-Western18296641 No
    BRD4 Affinity Capture-MS21555454 No
    UBC Affinity Capture-MS21139048|21890473|21906983 No
    ELAVL1 Affinity Capture-RNA19322201 No
    PML Affinity Capture-Western12006491|12006491 No
    LTA4H Co-fractionation22939629 CHD related
    NUDCD2 Co-fractionation22939629 No
    AHCY Co-fractionation22939629 No
    RBM25 Co-fractionation22939629 No
    KYNU Co-fractionation22939629 No


    Involved FDA drugs

    There was no drug associated with SIRT1