Basic Informations of Cystathionine gamma-lyase

Entrez Gene ID: 107869 [Pubmed]

UniProt Protein Name: Cystathionine gamma-lyase

UniProt ID: Q8VCN5

Related Drug:

DrugBank IDDrug Name
DB04217L-2-amino-3-butynoic acid
DB023282-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid
DB00114Pyridoxal Phosphate


..."Transgenic mice with cardiac-restricted overexpression of the H(2)S-generating enzyme cystathione gamma-lyase (alphaMHC-CGL-Tg(+)) displayed a clear protection against left ventricular structural and functional impairment as assessed by echocardiography in response to ischemia-induced heart failure, as well as improved survival in response to permanent myocardial ischemia."...

PMID:19752383|Circulation. 2009;120[suppl 1]:S31–S36
..."After baseline transthoracic echocardiography (TTE), adult ICR mice were injected i.p. with vehicle (10% DMSO) or tadalafil (1 mg/kg) with or without KT5823 (KT, PKG blocker, 1 mg/kg) or dl-propargylglycine (PAG, Cystathionine-gamma-lyase [CSE, H(2)S-producing enzyme] blocker; 50 mg/kg) 1 hour before coronary artery ligation for 30 minutes and reperfusion for 24 hours, whereas C57BL wild-type and CSE-knockout mice were treated with either vehicle or tadalafil. "...

[All Refs in Pubmed]

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