Basic Informations of Mineralocorticoid receptor

Entrez Gene ID: 110784 [Pubmed]

UniProt Protein Name: Mineralocorticoid receptor

UniProt ID: A3KN90


Related Drug:

DrugBank IDDrug Name
DB04652"(11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE"
DB04630Aldosterone
DB01395Drospirenone
DB01134Desoxycorticosterone Pivalate
DB01023Felodipine
DB00700Eplerenone
DB00687Fludrocortisone
DB00588Fluticasone Propionate
DB00421Spironolactone
DB00396Progesterone
DB00393Nimodipine

References

PMID:21242479|Circulation. 2011;123:400-408
..."Moreover, cardiomyocyte-specific MR ablation prevented the increases in myocardial and mitochondrial O(2)(ยท-) production and upregulation of the NADPH oxidase subunits Nox2 and Nox4."...

PMID:18427128|Circulation. 2008;117:2253-2261
..."MR blockade reduced expression of proinflammatory and prothrombotic factors in adipose tissue and increased expression of adiponectin in heart and adipose tissue of obese, diabetic mice. "...

PMID:19364981|Circulation. 2009;119:2179-2187
..."We suggest that in addition to modulation of Ca(2+) influx, overstimulation of the cardiac mineralocorticoid pathway in the heart might be a major upstream factor for aberrant Ca(2+) release during diastole, which contributes to cardiac arrhythmia in heart failure."...

[All Refs in Pubmed]



Network Situation

Node Details

The Selected Node Entrez Gene ID: ;
Protein Name:;

Expand Network with Neighbor Nodes

Click on Compounds Name to View Detail Descriptions
Num.Node NameNode Type
Relationships || Format: ||Change Views || Powered by Cytoscape Web

  • Tips
  • Click on Nodes to expand network with drugs and targets
  • See only TM or pp CVD network by reset with corresponding options
  • Highlight neighbor nodes just mouseover interested nodes
  • Find details of nodes and edges from tips when mouseover
  • Drag nodes or Zoom the network with panel in the bottom-right
  • Nodes and Edges
  • NodesType
    Blue RectTargets
    Yellow RectExpand Targets
    White borderTargets have drug
    Red VeeDrugs
    EdgesType
    Blue Text mining
    Red PPI