Basic Informations of Egl nine homolog 1

Entrez Gene ID: 112405 [Pubmed]

UniProt Protein Name: Egl nine homolog 1

UniProt ID: Q91YE3

Related Drug:

DrugBank IDDrug Name
DB00126Vitamin C


PMID:17646578|Circulation. 2007;116:774-781
..."PHD2, but not PHD1 and PHD3, is a major negative regulator for vascular growth in adult mice. "...

PMID:18040029|Circulation. 2007;116:2818-2829
...We demonstrate that aging decreased hypoxia-inducible factor 1alpha stabilization in ischemic tissues because of increased prolyl hydroxylase-mediated hydroxylation (P<0.05) and proteasomal degradation. ...

PMID:18591435|Circulation. 2008;118:166-175
..." Finally, selective small interfering RNA repression of prolylhydroxylase 2 resulted in significant activation of HIF-1 alpha and attenuated myocardial infarct sizes (0.44+/-0.09-fold). "...

PMID:19546390|Circulation. 2009;120:50-59
..."Mice with right femoral artery ligation were treated, by in vivo electrotransfer, with plasmids encoding for an irrelevant short hairpin RNA (shRNA) (shCON [control]) or specific shRNAs directed against HIF-1alpha (shHIF-1alpha), PHD1 (shPHD1), PHD2 (shPHD2), and PHD3 (shPHD3). "...

[All Refs in Pubmed]

Network Situation

Node Details

The Selected Node Entrez Gene ID: ;
Protein Name:;

Expand Network with Neighbor Nodes

Click on Compounds Name to View Detail Descriptions
Num.Node NameNode Type
Relationships || Format: ||Change Views || Powered by Cytoscape Web

  • Tips
  • Click on Nodes to expand network with drugs and targets
  • See only TM or pp CVD network by reset with corresponding options
  • Highlight neighbor nodes just mouseover interested nodes
  • Find details of nodes and edges from tips when mouseover
  • Drag nodes or Zoom the network with panel in the bottom-right
  • Nodes and Edges
  • NodesType
    Blue RectTargets
    Yellow RectExpand Targets
    White borderTargets have drug
    Red VeeDrugs
    Blue Text mining
    Red PPI