Basic Informations of Egl nine homolog 1

Entrez Gene ID: 112405 [Pubmed]

UniProt Protein Name: Egl nine homolog 1

UniProt ID: Q91YE3


Related Drug:

DrugBank IDDrug Name
DB08687N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
DB07112N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE
DB00126Vitamin C

References

PMID:17646578|Circulation. 2007;116:774-781
..."PHD2, but not PHD1 and PHD3, is a major negative regulator for vascular growth in adult mice. "...

PMID:18040029|Circulation. 2007;116:2818-2829
...We demonstrate that aging decreased hypoxia-inducible factor 1alpha stabilization in ischemic tissues because of increased prolyl hydroxylase-mediated hydroxylation (P<0.05) and proteasomal degradation. ...

PMID:18591435|Circulation. 2008;118:166-175
..." Finally, selective small interfering RNA repression of prolylhydroxylase 2 resulted in significant activation of HIF-1 alpha and attenuated myocardial infarct sizes (0.44+/-0.09-fold). "...

PMID:19546390|Circulation. 2009;120:50-59
..."Mice with right femoral artery ligation were treated, by in vivo electrotransfer, with plasmids encoding for an irrelevant short hairpin RNA (shRNA) (shCON [control]) or specific shRNAs directed against HIF-1alpha (shHIF-1alpha), PHD1 (shPHD1), PHD2 (shPHD2), and PHD3 (shPHD3). "...

[All Refs in Pubmed]



Network Situation

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