Basic Informations of ATP-binding cassette sub-family A member 1

Entrez Gene ID: 11303 [Pubmed]

UniProt Protein Name: ATP-binding cassette sub-family A member 1

UniProt ID: P41233


Related Drug:

DrugBank IDDrug Name
DB01599Probucol
DB01016Glyburide
DB00171Adenosine triphosphate

References

PMID:16940190|Circulation. 2006;114:1301-1309
...These data highlight the discrete and specific roles of both liver and extrahepatic ABCA1 in HDL biogenesis in vivo and indicate that ABCA1 shows lipid cargo selectivity depending on its site of expression...

PMID:20212278|Circulation. 2010;121:1347-1355
..."These data suggest a novel metabolic function of adipocytes in promoting cholesterol transfer to HDL in vivo and implicate adipocyte SR-BI and ABCA1, but not ABCG1, in this process."...

PMID:20385932|Circulation. 2010;121:1828-1837
..."The upregulation of ABCA1 and ABCG1 by erythropoietin resulted from liver X receptor alpha activation, which was confirmed by its prevention on expression of ABCA1 and ABCG1 after pharmacological or small interfering RNA inhibition of liver X receptor alpha. "...

PMID:21859969|Circulation. 2011;124:1382-1390
...These results explain the beneficial effects of probucol on atherosclerosis and xanthomas despite its HDL-lowering effects and suggest that inactivation of hepatic ABCA1 leads to increased RCT despite reducing plasma HDL-C levels....

PMID:21931081|Circulation. 2011;124:1663-1672
...Deletion of adipocyte ABCA1 resulted in a significant decrease in plasma HDL cholesterol (approximately 15%) and apolipoprotein A-I (approximately 13%) concentrations. ...

PMID:18852364|Circulation. 2008;118:1837-1847
...The results suggest that high-density lipoprotein and apolipoprotein A-1 exert anti-inflammatory effects by promoting cholesterol efflux via ABCG1 and ABCA1 with consequent attenuation of signaling via Toll-like receptors. ...

[All Refs in Pubmed]



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