Basic Informations of Adenosine receptor A1

Entrez Gene ID: 11539 [Pubmed]

UniProt Protein Name: Adenosine receptor A1

UniProt ID: Q60612


Related Drug:

DrugBank IDDrug Name
DB04932Defibrotide
DB01412Theobromine
DB01303Oxtriphylline
DB01223Aminophylline
DB00996Gabapentin
DB00806Pentoxifylline
DB00651Dyphylline
DB00640Adenosine
DB00277Theophylline
DB00201Caffeine

References

PMID:17088462|Circulation. 2006;114:2240-2250
..."These data suggest that robust constitutive myocardial A1-AR overexpression induces a dilated cardiomyopathy, whereas delaying A1-AR expression until adulthood ameliorated but did not eliminate the development of cardiac pathology."...

PMID:17438146|Circulation. 2007;115:2307-2315
...That the increase in A1-AR density was of physiological significance was shown by the fact that chronotropic responsiveness to the A1-AR selective agonist 2-chloro-N6-cyclopentanyladenosine was enhanced in the TNF 1.6 mice...

PMID:18824766|Circulation. 2008;118[suppl 1]:S32–S37
..."With the use of three distinctive strains of gene knockout mice, the current study has provided the first conclusive evidence showing PostC-induced infarct-limiting cardioprotection could be triggered by activation of multiple types of cell membrane receptors, which include adenosine A(1) and bradykinin B(2) receptors."...

[All Refs in Pubmed]



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