Basic Informations of Angiotensin II

Entrez Gene ID: 11606 [Pubmed]

UniProt Protein Name: Angiotensin II

UniProt ID: P11859

Related Drug:

No Related Drugs


PMID:16380549|Circulation. 2006;113:51-59
..."We tested the effects of several HDAC inhibitors, including a class I HDAC-selective inhibitor, SK-7041, on cardiac hypertrophy induced by angiotensin II (Ang II) treatment or aortic banding (AB)."...

PMID:16864727|Circulation. 2006;114:404-413
..." Deletion of p47phox attenuates Ang II-induced AAA formation in apoE-/- mice, suggesting that NADPH oxidase plays a critical role in AAA formation in this model."...

PMID:16908765|Circulation. 2006;114:953-960
...Ang II also significantly increased the number of senescent VSMCs and induced the expression of proinflammatory molecules and of p21 in a mouse model of atherosclerosis....

PMID:17562954|Circulation. 2007;115:3197-3204
..."Furthermore, the activation of apoptosis signal-regulating kinase 1 and its downstream effectors, c-Jun N-terminal kinase and p38 mitogen-activated protein kinase, in the hearts of Gq mice was reduced by long-term E2 treatment. Indeed, E2 (10 nmol/L)-treated cardiomyocytes were much more resistant to angiotensin II-induced apoptosis."...

PMID:18025526|Circulation. 2007;116:2587-2596
...The sarcomeric protein CS1 prevents Ang-II-induced cardiomyocyte hypertrophy at least in part via inhibition of calcineurin signaling...

PMID:20212283|Circulation. 2010;121:1338-1346
..."We demonstrated that in the angiotensin II-induced abdominal aortic aneurysm model, deficiency of the membrane attack complex regulator CD59 in ApoE-null mice (mCd59ab(-/-)/ApoE(-/-)) accelerated the disease development, whereas transgenic overexpression of human CD59 (hCD59(ICAM-2+/-)/ApoE(-/-)) in this model attenuated the progression of abdominal aortic aneurysm."...

PMID:20679547|Circulation. 2010;122:717-728
..."Ang II-mediated myocardial fibrosis and expression of procollagen type I alpha 1, procollagen type III alpha 1, transforming growth factor-beta1, and fibronectin were also suppressed by rhACE2. "...

PMID:19139386|Circulation. 2009;119:426-435
...Treatment of Apoe(-/-)/Cxcl10(-/-) mice with anti-transforming growth factor-beta neutralizing antibody diminished angiotensin II-induced aortic dilation....

PMID:19506106|Circulation. 2009;119:3125-3132
..." Pretreatment with rosiglitazone inhibited the Ang II-induced expression of angiotensin type 1a Ang II receptor while having no effect on the angiotensin type 2 Ang II receptor, in addition to reducing Ang II-induced expression of E-selectin, tumor necrosis factor-alpha, and interleukin-6."...

[All Refs in Pubmed]

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