Basic Informations of RAC-alpha serine/threonine-protein kinase

Entrez Gene ID: 11651 [Pubmed]

UniProt Protein Name: RAC-alpha serine/threonine-protein kinase

UniProt ID: P31750


Related Drug:

DrugBank IDDrug Name
DB07585"5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine"
DB07584"N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine"
DB01863"Inositol 1,3,4,5-Tetrakisphosphate"
DB01169Arsenic trioxide
DB00171Adenosine triphosphate

References

PMID:16636172|Circulation. 2006;113:2097-2104
...These results establish Akt1 as a pivotal regulatory switch that promotes physiological cardiac hypertrophy while antagonizing pathological hypertrophy...

PMID:16952979|Circulation. 2006;114:1159-1168
...This study suggests that inhibition of the calcineurin/NFAT signaling cascade by Foxo and release of this repressive action by the PI3K/Akt pathway are important mechanisms whereby Foxo factors govern cell growth in the heart...

PMID:17101854|Circulation. 2006;114:2498-2507
...PTP4B inhibition stimulated early eNOS phosphorylation and increased phosphorylation of Akt....

PMID:17646584|Circulation. 2007;116:654-663
..."In isolated myocytes, CXCR4 activation by SDF-1alpha resulted in increased phosphorylation of both ERK 1/2 and AKT and decreased phosphorylation of JNK and p38"...

PMID:17875968|Circulation. 2007;116:1585-1595
...We conclude that hyperglycemia triggers apoptosis by inhibiting Akt signaling via ONOO(-)-mediated LKB1-dependent PTEN activation....

PMID:17875968|Circulation. 2007;116:1585-1595
..."Furthermore, protein kinase B/Akt inhibition induced by ONOO- or high glucose and apoptosis triggered by high glucose could be abolished by transfection of PTEN-specific small interfering RNA, suggesting that PTEN mediated the Akt inhibition by ONOO-. "...

PMID:17893275|Circulation. 2007;116:1776-1783
...This was accompanied by a 4-fold greater increase in Bcl-2 and a 3-fold greater increase in phospho-Akt in AC5KO. ...

PMID:20026773|Circulation. 2010;121:132-142
...Our findings demonstrated that HDAC3 serves as an essential prosurvival molecule with a critical role in maintaining the endothelial integrity via Akt activation and that severe atherosclerosis and vessel rupture in isografted vessels of apolipoprotein E-knockout mice occur when HDAC3 is knocked down....

PMID:20083679|Circulation. 2010;121:537-548
..."CO enhanced EC proliferation via rapid activation of RhoA (Ras homolog gene family, member A), followed by downstream phosphorylation of Akt, endothelial nitric oxide (NO) synthase phosphorylation, and a 60% increase in NO generation by ECs. "...

PMID:20083677|Circulation. 2010;121:549-559
..." Infection with NoxA1 shRNA but not scrambled shRNA significantly decreased thrombin-induced activation of the redox-sensitive protein kinases (Janus kinase 2, Akt, and p38 mitogen-activated protein kinase) in VSMCs."...

PMID:20566952|Circulation.2010;122:11-19.
..."Additional experiments aimed at elucidating some of the protective mechanisms of H(2)S therapy found that 7 days of H(2)S therapy increased the phosphorylation of Akt and increased the nuclear localization of 2 transcription factors, nuclear respiratory factor 1 and nuclear factor-E2-related factor (Nrf2), that are involved in increasing the levels of endogenous antioxidants, attenuating apoptosis, and increasing mitochondrial biogenesis."...

PMID:20837912|Circulation. 2010;122:S185-S192
..." Adropin markedly upregulated vascular endothelial growth factor receptor-2 (VEGFR2) transcript and protein levels, and in VEGFR2-silenced endothelial cells, adropin failed to induce phosphorylation of endothelial NO synthase, Akt, and extracellular signal regulated kinase 1/2, supporting VEGFR2 as an upstream target of adropin-mediated endothelial NO synthase activation. "...

PMID:22082679|Circulation. 2011;124:2690-2701
..."These mice showed increased activation of gp130 downstream signaling targets (STAT3, ERK1/2, AKT, and p38) from 15 weeks of age and developed cardiac dysfunction from approximately 25 weeks of age with signs of heart failure."...

PMID:18195174|Circulation. 2008;117:545-552
..."Their swimming-induced activation of Akt, a key molecule in the signaling cascade of physiological hypertrophy, increased more than that seen in wild-type controls. "...

PMID:18427137|Circulation. 2008;117:2224-2231
..."Here we show that the secreted signaling protein stromal cell-derived factor-1alpha (SDF-1alpha), which activates the cell-survival factor protein kinase B (PKB/Akt) via the G protein-coupled receptor CXCR4, protected tissue after an acute ischemic event in mice and activated Akt within endothelial cells and myocytes of the heart. "...

PMID:18519848|Circulation. 2008;117:3099-3108
..."Adenovirus-mediated overexpression of Fstl1 protected cultured neonatal rat ventricular myocytes from hypoxia/reoxygenation-induced apoptosis (P<0.01), and this protective effect was dependent on the upregulation of both Akt and ERK activities."...

PMID:18663085|Circulation. 2008;118:731-742
..."This adverse effect of apoCIII was mediated by its activation of PKCbeta, which inhibits the IRS-1/PI3K/Akt/eNOS pathway."...

PMID:18711014|Circulation. 2008;118:1021-1033
..."PPAR-delta activation in EPCs phosphorylated Akt, and this phosphorylation was mediated not only by genomic but also by nongenomic pathways through interaction with the regulatory subunit of phosphatidylinositol 3-kinase. "...

PMID:18936328|Circulation. 2008;118:1979-1988
...Cav-3 OE mouse hearts had increased basal Akt and glycogen synthase kinase-3beta phosphorylation comparable to wild-type mice exposed to ischemic preconditioning....

PMID:19752325|Circulation. 2009;120:1231-1240
..."Using pharmacological (agonists and antagonists of Akt and its downstream target glycogen-synthase-kinase-3beta [GSK-3beta]) and molecular (forced expression of constitutively active Akt1) approaches, we showed that the effects of DHEA were mediated by inhibition of Akt and subsequent activation of GSK-3beta, leading to mitochondrial depolarization, increased reactive oxygen species, activation of redox-sensitive plasmalemmal voltage-gated K(+) channels, and decreased [Ca(2+)](i). "...

[All Refs in Pubmed]



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