Basic Informations of Aldose reductase

Entrez Gene ID: 11677 [Pubmed]

UniProt Protein Name: Aldose reductase

UniProt ID: P45376


Related Drug:

DrugBank IDDrug Name
DB08772"3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID"
DB08449"2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid"
DB08098"{[5-(5-NITRO-2-FURYL)-1,3,4-OXADIAZOL-2-YL]THIO}ACETIC ACID"
DB08084IDD594
DB08000"2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDE"
DB07999"{4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID"
DB07498"4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACID"
DB07450"2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONE"
DB071876-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE
DB071393-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid
DB07093"{3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID"
DB07063"{3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID"
DB07030(5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID
DB07028(2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID
DB04272Citric Acid
DB034612'-Monophosphoadenosine 5'-Diphosphoribose
DB02994Hydroxydimethylarsine Oxide
DB02834IDD552
DB02712Sorbinil
DB02518N-Acetylalanine
DB02383Tolrestat
DB02132"[3-(4-Bromo-2-Fluoro-Benzyl)-7-Chloro-2,4-Dioxo-3,4-Dihydro-2h-Quinazolin-1-Yl]-Acetic Acid"
DB02101Fidarestat(Stereoisomer)
DB02021Fidarestat
DB02020Alrestatin
DB02007Alpha-D-Glucose-6-Phosphate
DB01689Inhibitor Idd 384
DB00605Sulindac
DB00157NADH

References

PMID:17030682|Circulation. 2006;114:1838-1846
...The results of the present study show that pharmacological inhibition of aldose reductase by sorbinil or knockdown of the enzyme by small interfering RNA prevents the activation of nuclear factor-kappaB and the release of tumor necrosis factor-alpha from lipopolysaccharide-stimulated RAW264.7 or H9c2 cells...

[All Refs in Pubmed]



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