Basic Informations of Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Entrez Gene ID: 11938 [Pubmed]

UniProt Protein Name: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

UniProt ID: O55143


Related Drug:

No Related Drugs

References

PMID:16735677|Circulation. 2006;113:2589-2597
...Activation of the Raf-1-ERK pathway in normal cardiomyocytes resulted in decreased SERCA2a...

PMID:16880328|Circulation. 2006;114:574-582
..."Mechanistically, PKCalpha directly regulates Ca2+ handling by altering the phosphorylation status of inhibitor-1, which in turn suppresses protein phosphatase-1 activity, thus modulating phospholamban activity and secondarily, the sarcoplasmic reticulum Ca2+ ATPase."...

PMID:20124121|Circulation. 2010;121:792-803
...These results suggest that AMPK functions as a physiological suppressor of ER stress by maintaining SERCA activity and intracellular Ca2+ homeostasis....

PMID:18071070|Circulation. 2008;117:61-69
..." In addition, phospholamban phosphorylation was reduced (P=0.015), sarcoplasmic reticulum Ca2+-ATPase activity was impaired (P<0.0001), and cardiac myocytes showed marked abnormalities in calcium transient formation (P=0.001)."...

PMID:19139388|Circulation. 2009;119:436-444
..."The data demonstrate an association between the dose-dependent inhibition of SERCA2a activity by PLN(wt) and the time of onset of heart failure and show that a weak inhibitor of SERCA2a, PLN(R9C), which is diminished in its ability to modify the level of SERCA2a activity, leads to heart failure despite fast sarcoplasmic reticulum Ca(2+) reuptake."...

PMID:19451351|Circulation. 2009;119:2789-2797
..."Cardiac aging in mice is accompanied by accumulation of mitochondrial protein oxidation, increased mitochondrial DNA mutations and deletions and mitochondrial biogenesis, increased ventricular fibrosis, enlarged myocardial fiber size, decreased cardiac SERCA2 protein, and activation of the calcineurin-nuclear factor of activated T-cell pathway. "...

[All Refs in Pubmed]



Network Situation

Node Details

The Selected Node Entrez Gene ID: ;
Protein Name:;

Expand Network with Neighbor Nodes

Click on Compounds Name to View Detail Descriptions
Num.Node NameNode Type
Relationships || Format: ||Change Views || Powered by Cytoscape Web

  • Tips
  • Click on Nodes to expand network with drugs and targets
  • See only TM or pp CVD network by reset with corresponding options
  • Highlight neighbor nodes just mouseover interested nodes
  • Find details of nodes and edges from tips when mouseover
  • Drag nodes or Zoom the network with panel in the bottom-right
  • Nodes and Edges
  • NodesType
    Blue RectTargets
    Yellow RectExpand Targets
    White borderTargets have drug
    Red VeeDrugs
    EdgesType
    Blue Text mining
    Red PPI