Basic Informations of Apoptosis regulator Bcl-2

Entrez Gene ID: 12043 [Pubmed]

UniProt Protein Name: Apoptosis regulator Bcl-2

UniProt ID: Q4VBF6


Related Drug:

DrugBank IDDrug Name
DB01367Rasagiline
DB01248Docetaxel
DB01229Paclitaxel

References

PMID:17015789|Circulation. 2006;114:1713-1720
...Application of exogenous MK to cultured cardiomyocytes resulted in increased Bcl-2 expression and decreased apoptosis after hypoxia/reoxygenation....

PMID:17893275|Circulation. 2007;116:1776-1783
...This was accompanied by a 4-fold greater increase in Bcl-2 and a 3-fold greater increase in phospho-Akt in AC5KO. ...

PMID:20625112|Circulation. 2010;122:361-369
..."Furthermore, the Bcl2/Bax ratio was decreased in WT mice, whereas this change was significantly blunted in CHOP-deficient mice. "...

PMID:20713897|Circulation. 2010;122:891-899
...Overexpression of Bcl-2 or downregulation of p53 decreased the number of apoptotic cardiomyocytes and improved cardiac function. ...

PMID:19307478|Circulation. 2009;119:1795-1804
...no details...

PMID:19805648|Circulation. 2009;120:1606-1615
..."Activin A induced the expression of Bcl-2, and ablation of Bcl-2 by small interfering RNA abrogated its protective action in myocytes."...

[All Refs in Pubmed]



Network Situation

Node Details

The Selected Node Entrez Gene ID: ;
Protein Name:;

Expand Network with Neighbor Nodes

Click on Compounds Name to View Detail Descriptions
Num.Node NameNode Type
Relationships || Format: ||Change Views || Powered by Cytoscape Web

  • Tips
  • Click on Nodes to expand network with drugs and targets
  • See only TM or pp CVD network by reset with corresponding options
  • Highlight neighbor nodes just mouseover interested nodes
  • Find details of nodes and edges from tips when mouseover
  • Drag nodes or Zoom the network with panel in the bottom-right
  • Nodes and Edges
  • NodesType
    Blue RectTargets
    Yellow RectExpand Targets
    White borderTargets have drug
    Red VeeDrugs
    EdgesType
    Blue Text mining
    Red PPI