Basic Informations of Complement C3

Entrez Gene ID: 12266 [Pubmed]

UniProt Protein Name: Complement C3

UniProt ID: P01027


Related Drug:

DrugBank IDDrug Name
DB01915S-Hydroxycysteine
DB00028Intravenous Immunoglobulin

References

PMID:17145993|Circulation. 2006;114:2831-2838
..."Furthermore, interference with C3 activation with complement receptor-related gene y-Ig was associated with reduced vein graft thickening, reduced C3 and C9 deposition, and reduced inflammation as assessed by analysis of influx of inflammatory cells, such as leukocytes, T cells, and monocytes."...

PMID:18071075|Circulation. 2008;117:70-78
..."The peak in serum C3 levels after injury was markedly downregulated by C1-inhibitor, as evidenced by ELISA. Immunohistochemistry revealed strong expression of C3 and C3c, which colocalized to plaque macrophages and was reduced in C1-inhibitor-treated mice."...

PMID:18071075|Circulation. 2008;117:70-78
..."The peak in serum C3 levels after injury was markedly downregulated by C1-inhibitor, as evidenced by ELISA. Immunohistochemistry revealed strong expression of C3 and C3c, which colocalized to plaque macrophages and was reduced in C1-inhibitor-treated mice. for C3, a central protein in the activation of the complement system, and for its final major proteolytic fragment, C3c,which indicates a recent activation."...

PMID:18268142|Circulation. 2008;117:1055-1064
..."In addition, ptx3-deficient mice with acute myocardial infarction showed higher circulating levels of interleukin-6 and increased C3 deposition in lesional tissue."...

PMID:19307471|Circulation. 2009;119:1805-1813
..."Activation of the alternative pathway led to generation of the anaphylatoxins C3a and C5a, which recruited neutrophils to the aortic wall. Moreover, antagonism of both C3a and C5a activity was required to block AAA, which suggests that each can independently promote the aneurysmal phenotype."...

[All Refs in Pubmed]



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