Basic Informations of Caspase-1

Entrez Gene ID: 12362 [Pubmed]

UniProt Protein Name: Caspase-1

UniProt ID: P29452


Related Drug:

DrugBank IDDrug Name
DB079163-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
DB077443-[2-(2-BENZYLOXYCARBONYLAMINO-3-METHYL-BUTYRYLAMINO)-PROPIONYLAMINO]-4-OXO-PENTANOIC ACID
DB07733"1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE"
DB01017Minocycline

References

PMID:21282498|Circulation. 2011;123:594-604
..."In mice deficient for apoptosis-associated speck-like adaptor protein and caspase-1, these inflammatory responses and subsequent injuries, including infarct development and myocardial fibrosis and dysfunction, were markedly diminished."...

PMID:18474815|Circulation. 2008;117: 2670-2683
..."In vitro, anakinra significantly prevented apoptosis induced by simulated ischemia and inhibited caspase-1 and -9 activities."...

PMID:18541743|Circulation. 2008;117: 3079-3087
...Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor protein that regulates caspase-1-dependent IL-1 beta and IL-18 generation; ...

[All Refs in Pubmed]



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